Cheap Flights from Mexico City to Santiago Starting at $263

Mexico City is served primarily by Mexico City International Airport (MEX), the country’s main international hub handling most long-haul and full-service carriers, and the newer Felipe Ángeles International Airport (NLU), which typically hosts low-cost and domestic flights as a relief facility. MEX sits about 6–10 km east of downtown (roughly 20–40 minutes by road depending on traffic) with options including the metro/light-rail connection, airport shuttles, taxis, and ride-hailing services; fares can range from very low for public transit to moderate for private rides. NLU is farther northwest (around 40–60 km, often 50–90 minutes driving) and is usually reached by shuttle buses, taxis, and some intermodal links. MEX tends to be more convenient for international connections and public transport links, while NLU can be cheaper for budget carriers but may add transfer time and extra transport cost.

Arturo Merino Benítez (SCL) is Santiago’s primary international gateway and the country’s busiest hub, handling long-haul and regional carriers such as LATAM, Sky Airline and JetSMART. It sits roughly 15–18 km northwest of downtown Santiago; typical travel times are 20–40 minutes by car depending on traffic, with rideshare and taxis commonly costing in the mid-range for the city, while the airport rail/metro connection plus bus options can take 30–60 minutes for lower fares. The terminal offers full-service facilities and multiple lounges, making it comfortable for transfers, though peak-hour congestion and occasional security queues can slow processing. For travelers prioritizing nonstop international connectivity and amenities, SCL is usually the most convenient choice.

In different months, ticket prices from Mexico City to Santiago vary: minimum — $272 (October 2025), maximum — $334 (March 2026). Typically, the flight costs $302–$629.

The route Mexico City — Santiago is served by many carriers — 7 in total, including LATAM Chile, Aeromexico, Volaris, Avianca, Asian Air, Copa Airlines, and VivaAerobus. This gives passengers wide opportunities: from finding the lowest fare (from $263) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.