Cheap Flights from Mexico City to Santiago — $305

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Fly from Mexico City to Santiago with confidence — our search scans more than 700 airlines, 50+ travel agencies, and 5+ top booking systems to surface the best prices, schedules, and booking conditions for your trip. Friendly filters and clear comparison tools make it easy to find nonstop options, smart connections, or the ideal fare to suit your travel dates and budget.

Fly nonstop from Mexico City to Santiago for the fastest, most convenient way to reach Chile’s vibrant capital — fewer hassles, no layovers, and more time to enjoy the city. While connecting flights can sometimes be cheaper, a direct flight saves hours and offers a more comfortable, stress-free journey worth the extra convenience.

Mexico City is served primarily by Mexico City International Airport (MEX), the country’s main international hub handling most long-haul and full-service carriers, and the newer Felipe Ángeles International Airport (NLU), which typically hosts low-cost and domestic flights as a relief facility. MEX sits about 6–10 km east of downtown (roughly 20–40 minutes by road depending on traffic) with options including the metro/light-rail connection, airport shuttles, taxis, and ride-hailing services; fares can range from very low for public transit to moderate for private rides. NLU is farther northwest (around 40–60 km, often 50–90 minutes driving) and is usually reached by shuttle buses, taxis, and some intermodal links. MEX tends to be more convenient for international connections and public transport links, while NLU can be cheaper for budget carriers but may add transfer time and extra transport cost.

Arturo Merino Benítez (SCL) is Santiago’s primary international gateway and the country’s busiest hub, handling long-haul and regional carriers such as LATAM, Sky Airline and JetSMART. It sits roughly 15–18 km northwest of downtown Santiago; typical travel times are 20–40 minutes by car depending on traffic, with rideshare and taxis commonly costing in the mid-range for the city, while the airport rail/metro connection plus bus options can take 30–60 minutes for lower fares. The terminal offers full-service facilities and multiple lounges, making it comfortable for transfers, though peak-hour congestion and occasional security queues can slow processing. For travelers prioritizing nonstop international connectivity and amenities, SCL is usually the most convenient choice.

The Mexico City — Santiago route is served by multiple airlines, including LATAM Chile and Volaris. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $305, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.