Compare airlines, prices, and flight durations for your trip
Cheapest flights from Mexico City to Santiago
Fly from Mexico City to Santiago with confidence — our search scans more than 700 airlines, 50+ travel agencies, and 5+ top booking systems to surface the best prices, schedules, and booking conditions for your trip. Friendly filters and clear comparison tools make it easy to find nonstop options, smart connections, or the ideal fare to suit your travel dates and budget.
Remember that on average the ideal time to book flights is 2 months before departure!
Fly nonstop from Mexico City to Santiago for the fastest, most convenient way to reach Chile’s vibrant capital — fewer hassles, no layovers, and more time to enjoy the city. While connecting flights can sometimes be cheaper, a direct flight saves hours and offers a more comfortable, stress-free journey worth the extra convenience.
Schedule of direct flights from Mexico City to Santiago
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Santiago:
Mexico City airports overview
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Santiago airports overview
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Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Mexico City to Santiago
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$253
Asian Air
1 layover
15h 34m
01/11/2026
The cheapest one-way flight from Mexico City to Santiago departs on 01/11/2026, is operated by Asian Air and costs $253
Cheapest round trip flight
$595
Copa Airlines
1 layover
1d 22h 38m
02/02/2026
The cheapest roundtrip flight from Mexico City to Santiago departs on 02/02/2026, is operated by Copa Airlines and costs $595
The fastest flight
11h 40m
Fastest flight from Mexico City to Santiago takes 11h 40m
Direct flights
No direct flights
There are no direct flights on this route.
Earliest flight
10:00 AM
Latest flight
8:20 PM
Average flight duration
8h 15m
Direct flights count
10
Distance
6611km
Timezone difference
2h
The distance between Mexico City and Santiago is 6611km (4099 miles). The average flight duration is 8h 15m. There are 10 direct flights from Mexico City to Santiago. The time difference between Mexico City and Santiago is 2h. Flights from Mexico City begin at 10:00 AM. The latest flight from Mexico City departs at 8:20 PM
The route Mexico City — Santiago is served by many carriers — 8 in total, including Wamos Air, LATAM Chile, Aeromexico, Asian Air, Avianca, Gol Transportes Aéreos, Copa Airlines, and Volaris. This gives passengers wide opportunities: from finding the lowest fare (from $253) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
Mexico City is served primarily by Mexico City International Airport (MEX), the country’s main international hub handling most long-haul and full-service carriers, and the newer Felipe Ángeles International Airport (NLU), which typically hosts low-cost and domestic flights as a relief facility. MEX sits about 6–10 km east of downtown (roughly 20–40 minutes by road depending on traffic) with options including the metro/light-rail connection, airport shuttles, taxis, and ride-hailing services; fares can range from very low for public transit to moderate for private rides. NLU is farther northwest (around 40–60 km, often 50–90 minutes driving) and is usually reached by shuttle buses, taxis, and some intermodal links. MEX tends to be more convenient for international connections and public transport links, while NLU can be cheaper for budget carriers but may add transfer time and extra transport cost.
Flights from Mexico City to Santiago from $253 – Compare Airfares | Flaut.Travel
Arturo Merino Benítez (SCL) is Santiago’s primary international gateway and the country’s busiest hub, handling long-haul and regional carriers such as LATAM, Sky Airline and JetSMART. It sits roughly 15–18 km northwest of downtown Santiago; typical travel times are 20–40 minutes by car depending on traffic, with rideshare and taxis commonly costing in the mid-range for the city, while the airport rail/metro connection plus bus options can take 30–60 minutes for lower fares. The terminal offers full-service facilities and multiple lounges, making it comfortable for transfers, though peak-hour congestion and occasional security queues can slow processing. For travelers prioritizing nonstop international connectivity and amenities, SCL is usually the most convenient choice.
December 2025
Lowest price
on average:
$265
March 2026
Highest price
on average:
$361
Avg Price
What is the cheapest price for flights from Mexico City to Santiago?
The cheapest flight ticket from Mexico City to Santiago according to data for the last 48 hours costs $253
When is the best time to buy air tickets on the route Mexico City — Santiago?
Often the best time to buy tickets from Mexico City to Santiago is 2 months before departure.
When is the cheapest time of year to fly from Mexico City to Santiago?
Based on statistics over the past years, the lowest prices for flights from Mexico City to Santiago can be found flying in these months: December, January, March.
How long does it take to fly from Mexico City to Santiago?
The fastest flights from Mexico City to Santiago start from 11 hours 40 minutes in the air.
Which airline can fly direct from Mexico City to Santiago?
The following airlines operate direct flights on the route Mexico City — Santiago: Wamos Air, LATAM Chile, Aeromexico
In different months, ticket prices from Mexico City to Santiago vary: minimum — $265 (December 2025), maximum — $361 (March 2026). Typically, the flight costs $316–$684.
