LATAM Chile
Every day
starting at $379
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Mexico City to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
In different months, ticket prices from Mexico City to Santiago vary: minimum — $369 (February 2027), maximum — $524 (October 2026). Typically, the flight costs $419–$830.
A non-stop flight is the most convenient and comfortable way to fly from Mexico City to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
The only airline operating direct flights from Mexico City to Santiago is LATAM Chile. Flights operate every day.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Tickets from Mexico City to Santiago are getting cheaper month by month. From October 2026 to April 2027, the decline reached 24% — and that may not be the limit.
The most notable drop occurred from October 2026 to February 2027 — down 30%. The best period is January 2027–February 2027 (averaging $370), while the most expensive is October 2026–November 2026 ($477).
Since prices are falling, there's no rush to buy. The most cost-effective travel period is January 2027–February 2027: savings compared to expensive months can reach up to 23%.
Monthly price variation is 13.7%. Choosing the right departure date can lead to significant savings on this route.
LATAM Chile
Every day
starting at $379
All airports
Mexico City — Santiago
11/03/2026
Departure
Direct flight
AM10
starting at $1,215
Mexico City — Santiago
12/29/2026
Departure
Direct flight
AM10
starting at $358
Mexico City — Santiago
01/10/2027
Departure
Direct flight
LA621
starting at $391
Mexico City — Santiago
11/18/2026
Departure
Direct flight
AM10
starting at $611
Mexico City — Santiago
12/01/2026
Departure
Direct flight
AM10
starting at $614
Mexico City — Santiago
11/30/2026
Departure
Direct flight
AM10
starting at $623
Mexico City — Santiago
12/04/2026
Departure
Direct flight
AM10
starting at $641
Mexico City — Santiago
11/18/2026
Departure
Direct flight
LA621
starting at $668
Mexico City — Santiago
07/16/2027
Departure
Direct flight
LA621
starting at $733
Mexico City — Santiago
11/20/2026
Departure
Direct flight
AM10
starting at $921
starting at $358
starting at $391
starting at $310
starting at $349
starting at $406
starting at $510
The route Mexico City — Santiago is served by many carriers — 6 in total, including Aeromexico, LATAM Chile, Asian Air, Volaris, VivaAerobus, and Copa Airlines. This gives passengers wide opportunities: from finding the lowest fare (from $310) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
The cheapest flight ticket from Mexico City to Santiago according to data for the last 48 hours costs $310
Often the best time to buy tickets from Mexico City to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Santiago can be found flying in these months: February, January, April.
The fastest flights from Mexico City to Santiago start from 8 hours 20 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Santiago: Aeromexico, LATAM Chile
The cheapest one-way flight from Mexico City to Santiago departs on 01/09/2027, is operated by Asian Air and costs $310
The cheapest roundtrip flight from Mexico City to Santiago departs on 01/09/2027, is operated by Volaris and costs $784
Fastest flight from Mexico City to Santiago takes 8h 20m
There are direct flights on this route 6 days a week: Su, Mo, Tu, We, Th, and Fr
The distance between Mexico City and Santiago is 6608km (4097 miles). There are 8 direct flights from Mexico City to Santiago. The time difference between Mexico City and Santiago is 2h. Flights from Mexico City begin at 8:05 PM. The latest flight from Mexico City departs at 8:05 PM
