There are most likely no direct flights on the Mexico City — Santiago route
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A non-stop flight is the most convenient and comfortable way to fly from Mexico City to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Mexico City — Santiago route
Mexico City is served primarily by Mexico City International Airport (MEX), the country’s main international hub handling most long-haul and full-service carriers, and the newer Felipe Ángeles International Airport (NLU), which typically hosts low-cost and domestic flights as a relief facility. MEX sits about 6–10 km east of downtown (roughly 20–40 minutes by road depending on traffic) with options including the metro/light-rail connection, airport shuttles, taxis, and ride-hailing services; fares can range from very low for public transit to moderate for private rides. NLU is farther northwest (around 40–60 km, often 50–90 minutes driving) and is usually reached by shuttle buses, taxis, and some intermodal links. MEX tends to be more convenient for international connections and public transport links, while NLU can be cheaper for budget carriers but may add transfer time and extra transport cost.
Arturo Merino Benítez (SCL) is Santiago’s primary international gateway and the country’s busiest hub, handling long-haul and regional carriers such as LATAM, Sky Airline and JetSMART. It sits roughly 15–18 km northwest of downtown Santiago; typical travel times are 20–40 minutes by car depending on traffic, with rideshare and taxis commonly costing in the mid-range for the city, while the airport rail/metro connection plus bus options can take 30–60 minutes for lower fares. The terminal offers full-service facilities and multiple lounges, making it comfortable for transfers, though peak-hour congestion and occasional security queues can slow processing. For travelers prioritizing nonstop international connectivity and amenities, SCL is usually the most convenient choice.
In different months, ticket prices from Mexico City to Santiago vary: minimum — $298 (March 2027), maximum — $429 (December 2026). Typically, the flight costs $365–$761.
Ticket prices for Mexico City — Santiago are higher at the start and end of the period but lowest in the middle. This creates a convenient window for booking at a reduced price.
Prices fall from August 2026 to September 2026 (10%), then rise from September 2026 to December 2026 (+28%). The best period is August 2026–September 2026 ($354), the most expensive is November 2026–December 2026 ($409).
The best time to buy is August 2026–September 2026, when prices are at their lowest. This can save you up to 14% compared to the expensive months (November 2026–December 2026).
Monthly price variation is 12.2%. On this route, your departure date noticeably affects the cost, and choosing wisely can lead to real savings.
Mexico City — Santiago
09/18/2026
Departure
Direct flight
LA621
starting at $993
Mexico City — Santiago
11/04/2026
Departure
Direct flight
LA621
starting at $829
Mexico City — Santiago
11/16/2026
Departure
Direct flight
AM10
starting at $654
Mexico City — Santiago
03/07/2027
Departure
Direct flight
AM10
starting at $742
starting at $829
starting at $654
starting at $301
starting at $309
starting at $396
The route Mexico City — Santiago is served by many carriers — 5 in total, including LATAM Chile, Aeromexico, Volaris, Asian Air, and Avianca. This gives passengers wide opportunities: from finding the lowest fare (from $301) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
The cheapest flight ticket from Mexico City to Santiago according to data for the last 48 hours costs $301
Often the best time to buy tickets from Mexico City to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Santiago can be found flying in these months: March, September, August.
The fastest flights from Mexico City to Santiago start from 14 hours 29 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Santiago: LATAM Chile, Aeromexico
We couldn't find any special offers for flights from Mexico City to Santiago
The cheapest one-way flight from Mexico City to Santiago departs on 11/03/2026, is operated by Volaris and costs $301
The cheapest roundtrip flight from Mexico City to Santiago departs on 12/25/2026, is operated by LATAM Chile and costs $688
Fastest flight from Mexico City to Santiago takes 14h 29m
There are direct flights on this route 4 days a week: Su, Mo, We, and Fr
The distance between Mexico City and Santiago is 6608km (4097 miles). There are 8 direct flights from Mexico City to Santiago. The time difference between Mexico City and Santiago is 2h. Flights from Mexico City begin at 8:05 PM. The latest flight from Mexico City departs at 8:05 PM
