Helping travelers to find the best flight offers
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Santiago:
Unable to find information about the schedule of direct flights from
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Mexico City — Santiago
05/17/2025
Departure date
Direct flight
LA621
Starting at $1,759
Mexico City — Santiago
06/02/2025
Departure date
Direct flight
LA621
Starting at $685
Mexico City — Santiago
06/19/2025
Departure date
Direct flight
LA621
Starting at $739
Mexico City — Santiago
07/06/2025
Departure date
Direct flight
LA621
Starting at $956
Mexico City — Santiago
07/18/2025
Departure date
Direct flight
LA621
Starting at $767
Mexico City — Santiago
07/30/2025
Departure date
Direct flight
LA621
Starting at $721
Mexico City — Santiago
07/31/2025
Departure date
Direct flight
LA621
Starting at $597
Mexico City — Santiago
08/01/2025
Departure date
Direct flight
LA621
Starting at $624
Mexico City — Santiago
08/03/2025
Departure date
Direct flight
EB621
Starting at $756
The cheapest one-way flight from Mexico City to Santiago departs on 06/01/2025, is operated by Asian Air and costs $233
The cheapest roundtrip flight from Mexico City to Santiago departs on 08/06/2025, is operated by LATAM Chile and costs $478
Fastest flight from Mexico City to Santiago takes 12h 5m
There are no direct flights on this route.
The distance between Mexico City and Santiago is 6611km (4099 miles). There are 8 direct flights from Mexico City to Santiago. The time difference between Mexico City and Santiago is 2h . Flights from Mexico City begin at 8:20 PM. The latest flight from Mexico City departs at 8:20 PM.
The cheapest flight ticket from Mexico City to Santiago according to data for the last 48 hours costs $233
Often the best time to buy tickets from Mexico City to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Santiago can be found flying in these months: June, May, July.
The fastest flights from Mexico City to Santiago start from 12 hours 5 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Santiago: LATAM Chile, Wamos Air
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Mexico City to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Mexico City to Santiago
5월 16
Avianca
Below you will find a list of airlines operating flights on the Mexico City — Santiago route and the starting prices for flights of each specific airline on it.
A direct flight is the most convenient and comfortable way to fly from Mexico City to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
