Schedule of direct flights from Mexico City to Santiago
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Santiago:
Mexico City airports overview
Santiago airports overview
Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Mexico City to Santiago
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$243
Asian Air
1 transfer
14h 29m
09/02/2025
The cheapest one-way flight from Mexico City to Santiago departs on 09/02/2025, is operated by Asian Air and costs $243
Cheapest round trip flight
$576
Aeromexico
1 transfer
1d 22h 10m
05/12/2025
The cheapest roundtrip flight from Mexico City to Santiago departs on 05/12/2025, is operated by Aeromexico and costs $576
The fastest flight
8h 5m
Fastest flight from Mexico City to Santiago takes 8h 5m
Direct flights
Once a week
There are direct flights on this route 1 day a week: We
Earliest flight
10:05 AM
Latest flight
7:50 PM
Direct flights count
15
Distance
6611km
Timezone difference
2h
The distance between Mexico City and Santiago is 6611km (4099 miles).There are 15 direct flights from Mexico City to Santiago.The time difference between Mexico City and Santiago is 2h .Flights from Mexico City begin at 10:05 AM.The latest flight from Mexico City departs at 7:50 PM.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Mexico City to Santiago
Below you will find a list of airlines operating flights on the Mexico City — Santiago route and the starting prices for flights of each specific airline on it.
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Mexico City to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
Unable to find information about the schedule of direct flights from
A direct flight is the most convenient and comfortable way to fly from Mexico City to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
April 2025
Lowest price
on average:
$275
March 2025
Highest price
on average:
$328
How much is the cheapest flight ticket from Mexico City to Santiago?
The cheapest flight ticket from Mexico City to Santiago according to data for the last 48 hours costs $243
When is the best time to buy air tickets on the route Mexico City — Santiago?
Often the best time to buy tickets from Mexico City to Santiago is 2 months before departure.
When is the cheapest time of year to fly from Mexico City to Santiago?
Based on statistics over the past years, the lowest prices for flights from Mexico City to Santiago can be found flying in these months: April, March.
How long does it take to fly from Mexico City to Santiago?
The fastest flights from Mexico City to Santiago start from 8 hours 5 minutes in the air.
Which airline can fly direct from Mexico City to Santiago?
The following airlines operate direct flights on the route Mexico City — Santiago: LATAM Chile, Aeromexico
