Cheap Flights from Madrid to Santiago — $376

The minimum one-way ticket price from Madrid to Santiago is $322 (April 2026), while the maximum is $657 (November 2026). On average, a ticket costs $492–$985.

Looking for cheap flights from Madrid to Santiago? Look no further! At our air ticket search website, we make finding affordable and convenient flights easier than ever. Whether you're planning a business trip or a vacation, our user-friendly platform allows you to compare prices from various airlines and choose the best deal that suits your budget. With just a few clicks, you'll be able to find the cheapest flights from Madrid, Spain, to Santiago, Chile. Explore the vibrant culture of Chile's capital city, visit historical landmarks, or indulge in the delicious local cuisine. Don't let high airfare prices hold you back from experiencing all that Santiago has to offer. Start your journey today by searching for cheap flights on our website and make your dream trip a reality.

A non-stop flight is the most convenient and comfortable way to fly from Madrid to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.

The Madrid — Santiago route is served by a wide range of airlines: 9 in total, including Iberia, LATAM Chile, Avianca, United Airlines, Azul Brazilian Airlines, Air Europa, Ryanair, Aeromexico, and Air Canada. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $376. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.