Helping travelers to find the best flight offers
Fly from São Paulo to Santiago with confidence — our search combs through 700+ airlines, 50+ travel agencies and 5+ top booking systems to uncover the best prices, schedules and booking conditions for your trip. Quick comparisons and flexible options make it easy to pick the ideal flight for business or leisure and secure the deal that suits your plans.
The minimum one-way ticket price from Sao Paulo to Santiago is $106 (October 2025), while the maximum is $315 (September 2026). On average, a ticket costs $137–$226.
Fly direct from São Paulo to Santiago for the fastest, most convenient way to cross the continent—reach Chile’s capital quicker with fewer hassles and more comfortable travel. While connecting options can sometimes be cheaper, choosing a nonstop saves precious time and reduces stress, making it ideal for business trips or weekend escapes.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Sao Paulo to Santiago:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The Sao Paulo — Santiago route is served by a wide range of airlines: 6 in total, including Sky Airline, LATAM Chile, LATAM Brasil, Aerolineas Argentinas, Gol Transportes Aéreos, and B&H Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $69. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.
Starting at $69
Starting at $100
Starting at $122
Starting at $129
Starting at $140
Starting at $299
Sao Paulo — Santiago
12/01/2025
Departure
Direct flight
H2611
Starting at $69
Sao Paulo — Santiago
01/21/2026
Departure
Direct flight
H2611
Starting at $69
Sao Paulo — Santiago
01/19/2026
Departure
Direct flight
H2611
Starting at $70
Sao Paulo — Santiago
01/22/2026
Departure
Direct flight
H2611
Starting at $70
Sao Paulo — Santiago
11/04/2025
Departure
Direct flight
H2611
Starting at $70
Sao Paulo — Santiago
11/22/2025
Departure
Direct flight
H2611
Starting at $70
Sao Paulo — Santiago
12/08/2025
Departure
Direct flight
H2611
Starting at $70
Sao Paulo — Santiago
10/28/2025
Departure
Direct flight
H2611
Starting at $72
Sao Paulo — Santiago
12/05/2025
Departure
Direct flight
H2611
Starting at $72
Sao Paulo — Santiago
02/01/2026
Departure
Direct flight
H2611
Starting at $73
LATAM Chile
Every day
Starting at $201
Sky Airline
Mo, We, Th, Fr, and Sa
Starting at $98
LATAM Brasil
Mo and Fr
Starting at $146
Santiago is served primarily by Comodoro Arturo Merino Benítez International Airport (SCL), the country’s main international hub handling most long-haul and regional flights and a hub for carriers like LATAM and Sky Airline; a smaller secondary airport is occasionally used for domestic or charter services. SCL sits about 15–20 km northwest of downtown Santiago, with travel options including the airport train or commuter rail (roughly 20–40 minutes), express buses and regular shuttles (30–60 minutes), and taxis or ride-hailing (30–50 minutes); fares can range from modest bus fares to mid-range taxi/ride costs. Travelers usually find modern facilities and a broad route network, though peak times can mean longer security lines and higher on-site prices. For budget-conscious flyers, off-peak buses and shared shuttles are often the most economical choice, while business travelers may prefer the faster rail or taxi links for greater convenience.
The cheapest flight ticket from Sao Paulo to Santiago according to data for the last 48 hours costs $69
Often the best time to buy tickets from Sao Paulo to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Sao Paulo to Santiago can be found flying in these months: October, December, January.
The fastest flights from Sao Paulo to Santiago start from 4 hours 5 minutes in the air.
The following airlines operate direct flights on the route Sao Paulo — Santiago: Sky Airline
São Paulo–Guarulhos International (GRU) is the city’s main international gateway and a full-service hub for major carriers, typically handling long-haul and regional flights. Located about 25 km northeast of downtown São Paulo, travel times by car or taxi can be 30–60 minutes depending on traffic; the Airport Bus Service and EMTU buses take roughly 40–70 minutes with fares usually in the modest range, while the express rail link can be faster at peak times. Expect a wide choice of lounges, shops and onward connections, but also larger terminals and sometimes longer security and immigration queues — convenient for international itineraries but can be less compact than smaller fields. Congonhas Airport (CGH) functions mainly as a domestic and business-oriented airport, favored by full-service Brazilian carriers for frequent, short-haul connections. It sits about 8 km south of the central business district, with taxi or ride-hailing trips often taking 15–30 minutes; city buses and the local metro surface connections are available for lower fares but may take longer. The airport’s compact layout usually makes check-in and transfers quicker and more convenient, though it can be busier during peak business hours and offers fewer long-haul services and amenities compared with the international terminals. Viracopos/Campinas (VCP) is a secondary international airport located roughly 100 km northwest of São Paulo and can be a budget-friendly alternative for some international or low-cost carriers. Driving typically takes 1–1.5 hours depending on traffic; dedicated shuttle buses and intercity coaches connect to São Paulo with fares that vary by operator. VCP can offer lower fares and less crowded facilities, which some travelers prefer, but ground transfer time and fewer frequent direct city links make it less convenient for last-minute business trips or short stays. Campo de Marte (SBMT) primarily serves general aviation, executive flights and pilot training rather than scheduled commercial services. It’s situated about 7 km north of downtown São Paulo and reachable by taxi in 15–30 minutes under normal traffic, though public transit options are limited. The airport is typically quiet and easy to navigate for private and charter operations, but it won’t be suitable for most scheduled passenger flights and lacks the retail and transfer infrastructure of the larger commercial airports.
We couldn't find any special offers for flights from Sao Paulo to Santiago
The cheapest one-way flight from Sao Paulo to Santiago departs on 12/01/2025, is operated by Sky Airline and costs $69
The cheapest roundtrip flight from Sao Paulo to Santiago departs on 11/21/2025, is operated by Sky Airline and costs $146
Fastest flight from Sao Paulo to Santiago takes 4h 5m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Sao Paulo and Santiago is 2566km (1591 miles). The average flight duration is 4h 20m. There are 84 direct flights from Sao Paulo to Santiago. The time difference between Sao Paulo and Santiago is 1h. Flights from Sao Paulo begin at 4:35 AM. The latest flight from Sao Paulo departs at 3:40 AM