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Cheapest flights from Santiago to Panama City
Fly from Santiago to Panama City with confidence — our search scans over 700 airlines, 50+ travel agencies and 5+ top booking systems to surface the best fares, schedules and ticket conditions for your trip. Compare options in seconds and lock in the flight that matches your budget and itinerary.
Remember that on average the ideal time to book flights is 2 months before departure!
Fly nonstop from Santiago to Panama City for the fastest, most convenient way to connect Chile and Panama—perfect for business trips or a quick tropical escape. While connecting options can sometimes be cheaper, a direct flight saves hours and hassle, giving you more time to enjoy Panama’s city sights and nearby beaches.
Schedule of direct flights from Santiago to Panama City
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Panama City:
Santiago airports overview
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Panama City airports overview
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Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Santiago to Panama City
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$266
Avianca
1 layover
10h 15m
01/21/2026
The cheapest one-way flight from Santiago to Panama City departs on 01/21/2026, is operated by Avianca and costs $266
Cheapest round trip flight
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There is no information about the cheapest roundtrip flight from Santiago to Panama City
The fastest flight
10h 15m
Fastest flight from Santiago to Panama City takes 10h 15m
Direct flights
No direct flights
There are no direct flights on this route.
Earliest flight
5:11 AM
Latest flight
3:35 AM
Direct flights count
42
Distance
4810km
Timezone difference
1h
The distance between Santiago and Panama City is 4810km (2982 miles). There are 42 direct flights from Santiago to Panama City. The time difference between Santiago and Panama City is 1h. Flights from Santiago begin at 5:11 AM. The latest flight from Santiago departs at 3:35 AM
February 2026
Lowest price
on average:
$229
May 2026
Highest price
on average:
$285
Avg Price
The route Santiago — Panama City is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $266 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
Comodoro Arturo Merino Benítez (SCL) is Santiago’s main international gateway and typically functions as Chile’s primary hub for long-haul and regional carriers such as LATAM and Sky Airline, while some low-cost operators also serve the airport. It’s located about 15–20 km northwest of the city center, with travel times typically around 20–40 minutes by car depending on traffic. Public options include the airport bus and taxis/rideshares; transfers can often cost in the moderate range for Santiago, while buses are usually the cheaper choice. Pros: convenient connections and full passenger services; cons: can be busy at peak times and road congestion may affect transfer times.
Tocumen International Airport (PTY) is Panama City’s main international gateway and a regional hub for connecting flights across the Americas, typically handling full-service carriers as well as many international low-cost airlines. Located about 24 km (roughly 30–40 minutes by car, depending on traffic) from downtown Panama City, transfer options include taxis, ride-hailing services and airport buses; fares can vary widely but taxis and rideshares generally cost more than the public bus. PTY tends to be perceived as mid-range to premium for international connections, offering extensive lounges, shopping and dining; its size can mean longer walking distances and occasional peak-time delays.
Albrook “Marcos A. Gelabert” International Airport (PAC) serves mainly domestic flights and short regional hops, and is often used by budget and domestic carriers. It sits much closer to the city center — around 6 km (about 10–20 minutes by road) — and is commonly reached by taxi, rideshare or local buses at modest fares. Albrook is convenient for quick access to central Panama City and is typically easier to navigate than the larger international airport, though it has fewer international connections and limited facilities compared with Tocumen.
We couldn't find any special offers for flights from Santiago to Panama City
What is the cheapest price for flights from Santiago to Panama City?
The cheapest flight ticket from Santiago to Panama City according to data for the last 48 hours costs $266
When is the best time to buy air tickets on the route Santiago — Panama City?
Often the best time to buy tickets from Santiago to Panama City is 2 months before departure.
When is the cheapest time of year to fly from Santiago to Panama City?
Based on statistics over the past years, the lowest prices for flights from Santiago to Panama City can be found flying in these months: February, December, May.
How long does it take to fly from Santiago to Panama City?
The fastest flights from Santiago to Panama City start from 10 hours 15 minutes in the air.
Which airline can fly direct from Santiago to Panama City?
The following airlines operate direct flights on the route Santiago — Panama City: Copa Airlines
The minimum one-way ticket price from Santiago to Panama City is $229 (February 2026), while the maximum is $285 (May 2026). On average, a ticket costs $256–$540.
