Cheap Flights from Santiago to Panama City — $230

The Santiago — Panama City route is served by a wide range of airlines: 4 in total, including Copa Airlines, Avianca, Sky Airline, and LATAM Chile. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $230. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.

Tocumen International Airport (PTY) is Panama City’s main international gateway and a regional hub for connecting flights across the Americas, typically handling full-service carriers as well as many international low-cost airlines. Located about 24 km (roughly 30–40 minutes by car, depending on traffic) from downtown Panama City, transfer options include taxis, ride-hailing services and airport buses; fares can vary widely but taxis and rideshares generally cost more than the public bus. PTY tends to be perceived as mid-range to premium for international connections, offering extensive lounges, shopping and dining; its size can mean longer walking distances and occasional peak-time delays. Albrook “Marcos A. Gelabert” International Airport (PAC) serves mainly domestic flights and short regional hops, and is often used by budget and domestic carriers. It sits much closer to the city center — around 6 km (about 10–20 minutes by road) — and is commonly reached by taxi, rideshare or local buses at modest fares. Albrook is convenient for quick access to central Panama City and is typically easier to navigate than the larger international airport, though it has fewer international connections and limited facilities compared with Tocumen.

Several times a week

The distance between Santiago and Panama City is 4810km (2982 miles). The time difference between Santiago and Panama City is 1h

Comodoro Arturo Merino Benítez (SCL) is Santiago’s main international gateway and typically functions as Chile’s primary hub for long-haul and regional carriers such as LATAM and Sky Airline, while some low-cost operators also serve the airport. It’s located about 15–20 km northwest of the city center, with travel times typically around 20–40 minutes by car depending on traffic. Public options include the airport bus and taxis/rideshares; transfers can often cost in the moderate range for Santiago, while buses are usually the cheaper choice. Pros: convenient connections and full passenger services; cons: can be busy at peak times and road congestion may affect transfer times.

The minimum one-way ticket price from Santiago to Panama City is $230 (May 2026), while the maximum is $288 (January 2027). On average, a ticket costs $240–$250.