There are most likely no direct flights on the Santiago — Panama City route
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A non-stop flight is the most convenient and comfortable way to fly from Santiago to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Santiago — Panama City route
All airports
The minimum one-way ticket price from Santiago to Panama City is $361 (February 2027), while the maximum is $388 (January 2027). On average, a ticket costs $375–$388.
Santiago — Panama City
12/05/2026
Departure
Direct flight
CM396
starting at $710
Santiago — Panama City
11/22/2026
Departure
Direct flight
CM475
starting at $793
Santiago — Panama City
03/04/2027
Departure
Direct flight
CM396
starting at $793
Santiago — Panama City
02/22/2027
Departure
Direct flight
CM118
starting at $800
Santiago — Panama City
11/21/2026
Departure
Direct flight
CM498
starting at $795
Santiago — Panama City
06/15/2027
Departure
Direct flight
CM276
starting at $802
Santiago — Panama City
01/08/2027
Departure
Direct flight
CM118
starting at $865
Santiago — Panama City
12/04/2026
Departure
Direct flight
CM498
starting at $730
Santiago — Panama City
01/23/2027
Departure
Direct flight
CM276
starting at $758
The route Santiago — Panama City is served by several airlines: Copa Airlines, Avianca, and LATAM Chile. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $328 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Santiago to Panama City according to data for the last 48 hours costs $328
Often the best time to buy tickets from Santiago to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Panama City can be found flying in these months: February, January.
The fastest flights from Santiago to Panama City start from 9 hours in the air.
The following airlines operate direct flights on the route Santiago — Panama City: Copa Airlines
The cheapest one-way flight from Santiago to Panama City departs on 12/04/2026, is operated by Avianca and costs $328
The cheapest roundtrip flight from Santiago to Panama City departs on 11/21/2026, is operated by Avianca and costs $650
Fastest flight from Santiago to Panama City takes 9 hours
There are direct flights on this route 6 days a week: Su, Mo, Tu, Th, Fr, and Sa
The distance between Santiago and Panama City is 4811km (2983 miles). There are 43 direct flights from Santiago to Panama City. The time difference between Santiago and Panama City is 1h. Flights from Santiago begin at 4:14 AM. The latest flight from Santiago departs at 3:14 AM
We couldn't find any special offers for flights from Santiago to Panama City
