Cheap Flights from Santiago to Panama City — $266

The route Santiago — Panama City is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $266 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.

Comodoro Arturo Merino Benítez (SCL) is Santiago’s main international gateway and typically functions as Chile’s primary hub for long-haul and regional carriers such as LATAM and Sky Airline, while some low-cost operators also serve the airport. It’s located about 15–20 km northwest of the city center, with travel times typically around 20–40 minutes by car depending on traffic. Public options include the airport bus and taxis/rideshares; transfers can often cost in the moderate range for Santiago, while buses are usually the cheaper choice. Pros: convenient connections and full passenger services; cons: can be busy at peak times and road congestion may affect transfer times.

Tocumen International Airport (PTY) is Panama City’s main international gateway and a regional hub for connecting flights across the Americas, typically handling full-service carriers as well as many international low-cost airlines. Located about 24 km (roughly 30–40 minutes by car, depending on traffic) from downtown Panama City, transfer options include taxis, ride-hailing services and airport buses; fares can vary widely but taxis and rideshares generally cost more than the public bus. PTY tends to be perceived as mid-range to premium for international connections, offering extensive lounges, shopping and dining; its size can mean longer walking distances and occasional peak-time delays. Albrook “Marcos A. Gelabert” International Airport (PAC) serves mainly domestic flights and short regional hops, and is often used by budget and domestic carriers. It sits much closer to the city center — around 6 km (about 10–20 minutes by road) — and is commonly reached by taxi, rideshare or local buses at modest fares. Albrook is convenient for quick access to central Panama City and is typically easier to navigate than the larger international airport, though it has fewer international connections and limited facilities compared with Tocumen.

The minimum one-way ticket price from Santiago to Panama City is $229 (February 2026), while the maximum is $285 (May 2026). On average, a ticket costs $256–$540.