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Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santiago to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Santiago to Panama City
A non-stop flight is the most convenient and comfortable way to fly from Santiago to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
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Santiago — Panama City
05/29/2026
Departure
Direct flight
CM396
starting at $1,075
Santiago — Panama City
06/06/2026
Departure
Direct flight
CM396
starting at $670
Santiago — Panama City
06/07/2026
Departure
Direct flight
CM475
starting at $863
Santiago — Panama City
06/20/2026
Departure
Direct flight
CM276
starting at $1,102
Santiago — Panama City
09/26/2026
Departure
Direct flight
CM498
starting at $1,094
The route Santiago — Panama City is served by several airlines: Copa Airlines, Wamos Air, and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $276 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Santiago to Panama City according to data for the last 48 hours costs $276
Often the best time to buy tickets from Santiago to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Panama City can be found flying in these months: May.
The fastest flights from Santiago to Panama City start from 8 hours 35 minutes in the air.
The following airlines operate direct flights on the route Santiago — Panama City: Copa Airlines
The cheapest one-way flight from Santiago to Panama City departs on 06/07/2026, is operated by Wamos Air and costs $276
The cheapest roundtrip flight from Santiago to Panama City departs on 07/24/2026, is operated by Avianca and costs $613
Fastest flight from Santiago to Panama City takes 8h 35m
There are direct flights on this route 3 days a week: Su, Fr, and Sa
The distance between Santiago and Panama City is 4810km (2982 miles). There are 4 direct flights from Santiago to Panama City. The time difference between Santiago and Panama City is 1h. Flights from Santiago begin at 4:09 AM. The latest flight from Santiago departs at 2:22 AM
Comodoro Arturo Merino Benítez (SCL) is Santiago’s main international gateway and typically functions as Chile’s primary hub for long-haul and regional carriers such as LATAM and Sky Airline, while some low-cost operators also serve the airport. It’s located about 15–20 km northwest of the city center, with travel times typically around 20–40 minutes by car depending on traffic. Public options include the airport bus and taxis/rideshares; transfers can often cost in the moderate range for Santiago, while buses are usually the cheaper choice. Pros: convenient connections and full passenger services; cons: can be busy at peak times and road congestion may affect transfer times.
Tocumen International Airport (PTY) is Panama City’s main international gateway and a regional hub for connecting flights across the Americas, typically handling full-service carriers as well as many international low-cost airlines. Located about 24 km (roughly 30–40 minutes by car, depending on traffic) from downtown Panama City, transfer options include taxis, ride-hailing services and airport buses; fares can vary widely but taxis and rideshares generally cost more than the public bus. PTY tends to be perceived as mid-range to premium for international connections, offering extensive lounges, shopping and dining; its size can mean longer walking distances and occasional peak-time delays. Albrook “Marcos A. Gelabert” International Airport (PAC) serves mainly domestic flights and short regional hops, and is often used by budget and domestic carriers. It sits much closer to the city center — around 6 km (about 10–20 minutes by road) — and is commonly reached by taxi, rideshare or local buses at modest fares. Albrook is convenient for quick access to central Panama City and is typically easier to navigate than the larger international airport, though it has fewer international connections and limited facilities compared with Tocumen.
