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The cost of a one-way flight from Santiago to Medellin ranges from $132 (October 2025) to $189 (December 2025). On average, the ticket price is about $146–$150.
Fly nonstop from Santiago to Medellín for the quickest, most convenient way to link Chile’s capital with Colombia’s vibrant city—no layovers, less hassle, and more time to enjoy your trip. While connecting options can sometimes be cheaper, a direct flight saves hours and offers a smoother, more comfortable journey so you arrive refreshed and ready to explore.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Medellin:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The cheapest one-way flight from Santiago to Medellin departs on 11/12/2025, is operated by B&H Airlines and costs $150
There is no information about the cheapest roundtrip flight from Santiago to Medellin
Fastest flight from Santiago to Medellin takes 9h 20m
There are no direct flights on this route.
The distance between Santiago and Medellin is 4440km (2753 miles). The time difference between Santiago and Medellin is 1h
More than 4 airlines operate flights from Santiago to Medellin, including B&H Airlines, LATAM Chile, Avianca, and Copa Airlines. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $150, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
Starting at $150
Starting at $172
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Santiago’s main gateway is Comodoro Arturo Merino Benítez International (SCL), the country’s largest international hub handling most long-haul and regional flights and commonly served by full-service carriers as well as several low-cost airlines. It sits about 15–20 km northwest of downtown Santiago, with travel times typically ranging from 20–45 minutes by taxi or ride‑share depending on traffic; airport shuttles and the Line 1 metro extension plus bus services can also connect you in roughly 30–60 minutes for modest fares. A smaller option for private and some domestic traffic can be found at nearby smaller aerodromes. Pros: modern terminal facilities and a wide route network. Cons: peak-hour congestion and distance from the city center can add time and cost to transfers.
José María Córdova International (MDE) is Medellín’s primary international gateway, serving long-haul and regional carriers including Avianca, LATAM and several low-cost airlines on international routes. Located about 35 km southeast of downtown Medellín in Rionegro, transfers typically take 40–60 minutes by taxi or private shuttle and can be longer in peak traffic; shared vans and airport buses offer cheaper alternatives with fares usually lower than private cars. Expect a more complete set of passenger services and international connections here, though travel time to the city can add cost and complexity. Pros: wide route network and facilities; cons: longer transfer times and occasional congestion. Olaya Herrera Airport (EOH) functions mainly as Medellín’s domestic and regional airport, handling short-haul flights and turboprops operated by regional carriers. Sitting roughly 4 km from the city center, it is easily reachable by taxi or ride-hail in about 10–20 minutes, with fares typically cheaper than transfers from the international airport. Its compact terminals make for quick check-ins and short walks, but expect fewer amenities and limited international options. Pros: proximity and fast city access; cons: fewer services and airlines compared with the international airport, and smaller aircraft facilities.
The cheapest flight ticket from Santiago to Medellin according to data for the last 48 hours costs $150
Often the best time to buy tickets from Santiago to Medellin is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Medellin can be found flying in these months: October, November, February.
The fastest flights from Santiago to Medellin start from 9 hours 20 minutes in the air.
The following airlines operate direct flights on the route Santiago — Medellin:
We couldn't find any special offers for flights from Santiago to Medellin