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Fly from Mexico City to Medellín with confidence — our search checks over 700 airlines, 50+ travel agencies and 5+ top booking systems to uncover the best prices, schedules and ticket conditions for your trip. Compare options in seconds and book the flight that fits your budget and timing.
Fly nonstop from Mexico City to Medellín for the quickest, most convenient way to connect these two vibrant cities — fewer hassles, no layovers, and more time to enjoy the destination. If budget is your top priority, connecting options can sometimes be cheaper, but direct flights are the faster, more comfortable choice for stress-free travel.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Medellin:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
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Mexico City is served primarily by Mexico City International Airport (Benito Juárez, MEX), a major international hub handling full-service carriers like Aeroméxico and many foreign airlines alongside low-cost operators; it’s typically the main choice for long-haul and business travel. For lower-cost domestic and regional flights, Felipe Ángeles International (NLU) and Toluca (TLC) can be alternatives that often offer cheaper fares but are farther from central neighborhoods. MEX sits about 9–15 km from the historic center, reachable by taxi or rideshare in roughly 20–40 minutes (fares and times vary with traffic), and also by bus or metro connections for lower fares. Pros: extensive route network and frequent service; cons: heavy traffic, busy terminals, and potential delays during peak hours.
Medellín is served by two main airports with different roles. José María Córdova International (MDE) near Rionegro functions as the city’s international gateway and is typically used by full-service carriers and many regional flights; fares can be mid-to-high relative to domestic options. It sits about 35–45 km (roughly 40–60 minutes by car) from downtown Medellín depending on traffic; shuttle buses and taxis are common (shared shuttles from about COP-equivalent fares to private transfers costing more). Olaya Herrera (EOH) is a smaller, centrally located domestic airport favored by budget and regional airlines, around 5–10 minutes from the city center by taxi and often cheaper for short hops. Pros: MDE offers broader international connectivity; EOH is convenient for quick domestic trips. Cons: MDE’s distance adds transfer time and variable road congestion, while EOH has limited long-haul options.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Mexico City to Medellin
Mexico City — Medellin
10/21/2025
Departure
Direct flight
AM798
Starting at $371
Mexico City — Medellin
12/11/2025
Departure
Direct flight
AV235
Starting at $294
Mexico City — Medellin
12/31/2025
Departure
Direct flight
AM798
Starting at $722
Starting at $226
Starting at $160
The Mexico City — Medellin route is served by multiple airlines, including Aeromexico and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $160, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
The cheapest flight ticket from Mexico City to Medellin according to data for the last 48 hours costs $160
Often the best time to buy tickets from Mexico City to Medellin is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Medellin can be found flying in these months: November.
The fastest flights from Mexico City to Medellin start from 7 hours 55 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Medellin: Aeromexico, Avianca
We couldn't find any special offers for flights from Mexico City to Medellin
The cheapest one-way flight from Mexico City to Medellin departs on 12/11/2025, is operated by Avianca and costs $160
The cheapest roundtrip flight from Mexico City to Medellin departs on 11/12/2025, is operated by Copa Airlines and costs $299
Fastest flight from Mexico City to Medellin takes 7h 55m
There are no direct flights on this route.
The distance between Mexico City and Medellin is 2938km (1822 miles). There are 16 direct flights from Mexico City to Medellin. The time difference between Mexico City and Medellin is 1h. Flights from Mexico City begin at 5:00 AM. The latest flight from Mexico City departs at 7:00 PM