Helping travelers to find the best flight offers
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santo Domingo to Panama City:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
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A direct flight is the most convenient and comfortable way to fly from Santo Domingo to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
Santo Domingo — Panama City
03/28/2025
Departure date
Direct flight
CM299
Starting at $601
Santo Domingo — Panama City
03/29/2025
Departure date
Direct flight
CM129
Starting at $595
Santo Domingo — Panama City
03/30/2025
Departure date
Direct flight
CM299
Starting at $540
Santo Domingo — Panama City
04/09/2025
Departure date
Direct flight
CM129
Starting at $599
Santo Domingo — Panama City
04/12/2025
Departure date
Direct flight
CM129
Starting at $667
Santo Domingo — Panama City
04/30/2025
Departure date
Direct flight
CM299
Starting at $591
Santo Domingo — Panama City
05/04/2025
Departure date
Direct flight
CM464
Starting at $743
Santo Domingo — Panama City
05/12/2025
Departure date
Direct flight
CM267
Starting at $585
Santo Domingo — Panama City
05/13/2025
Departure date
Direct flight
CM299
Starting at $581
Santo Domingo — Panama City
05/20/2025
Departure date
Direct flight
CM299
Starting at $585
The cheapest one-way flight from Santo Domingo to Panama City departs on 05/20/2025, is operated by Avianca and costs $156
The cheapest roundtrip flight from Santo Domingo to Panama City departs on 08/11/2025, is operated by Avianca and costs $459
Fastest flight from Santo Domingo to Panama City takes 5h 45m
There are no direct flights on this route.
The distance between Santo Domingo and Panama City is 1474km (914 miles). The average flight duration is 2h 35m. There are 36 direct flights from Santo Domingo to Panama City. The time difference between Santo Domingo and Panama City is 1h . Flights from Santo Domingo begin at 6:18 AM. The latest flight from Santo Domingo departs at 6:37 PM.
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santo Domingo to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Santo Domingo to Panama City
Below you will find a list of airlines operating flights on the Santo Domingo — Panama City route and the starting prices for flights of each specific airline on it.
We couldn't find any special offers for flights from Santo Domingo to Panama City
The cheapest flight ticket from Santo Domingo to Panama City according to data for the last 48 hours costs $156
Often the best time to buy tickets from Santo Domingo to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Panama City can be found flying in these months: March, May, April.
The fastest flights from Santo Domingo to Panama City start from 5 hours 45 minutes in the air.
The following airlines operate direct flights on the route Santo Domingo — Panama City: Copa Airlines
