Cheap Flights from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City

Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santo Domingo to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.

Cheapest one way flight

$231

Avianca

1 transfer

13h 40m

11/18/2025

The cheapest one-way flight from Santo Domingo to Panama City departs on 11/18/2025, is operated by Avianca and costs $231

Cheapest round trip flight

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There is no information about the cheapest roundtrip flight from Santo Domingo to Panama City

The fastest flight

8h 49m

Fastest flight from Santo Domingo to Panama City takes 8h 49m

Direct flights

No direct flights

There are no direct flights on this route.

Earliest flight

6:00 AM

Latest flight

6:43 PM

Direct flights count

34

Distance

1474km

Timezone difference

1h

The distance between Santo Domingo and Panama City is 1474km (914 miles). There are 34 direct flights from Santo Domingo to Panama City. The time difference between Santo Domingo and Panama City is 1h. Flights from Santo Domingo begin at 6:00 AM. The latest flight from Santo Domingo departs at 6:43 PM

Remember that on average the ideal time to book flights is 2 months before departure!

Airfare from Santo Domingo to Panama City by month

The minimum one-way ticket price from Santo Domingo to Panama City is $241 (October 2025), while the maximum is $305 (January 2026). On average, a ticket costs $267–$559.

October 2025

Lowest price

on average:

$241

January 2026

Highest price

on average:

$305

Avg Price

Airlines operating on route

The route Santo Domingo — Panama City is served by several airlines: Copa Airlines, Avianca, and American Airlines. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $231 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.

Copa Airlines

Starting at $605

Avianca

Starting at $231

American Airlines

Starting at $275

Direct Flights from Santo Domingo to Panama City

A direct flight is the most convenient and comfortable way to fly from Santo Domingo to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.

Santo Domingo — Panama City

SDQ — PTY

11/17/2025

Departure

Direct flight

CM464

Starting at $672

Santo Domingo — Panama City

SDQ — PTY

11/18/2025

Departure

Direct flight

CM299

Starting at $605

Schedule of direct flights from Santo Domingo to Panama City

A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santo Domingo to Panama City:

Unable to find information about the schedule of direct flights from

Santo Domingo airports overview

La Isabela International Airport

•

JBQ

9km

Las Americas International Airport

•

SDQ

34km

Serving Santo Domingo, Dominican Republic, handling domestic and international flights with regular connections across the Caribbean and the Americas; convenient for access to the capital and nearby resort areas.

•

Panama City airports overview

Marcos A. Gelabert International Airport

•

PAC

34km

Tocumen International Airport

•

PTY

17km

•

Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

How much is the cheapest flight ticket from Santo Domingo to Panama City?

The cheapest flight ticket from Santo Domingo to Panama City according to data for the last 48 hours costs $231

When is the best time to buy air tickets on the route Santo Domingo — Panama City?

Often the best time to buy tickets from Santo Domingo to Panama City is 2 months before departure.

When is the cheapest time of year to fly from Santo Domingo to Panama City?

Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Panama City can be found flying in these months: October, March, January.

How long does it take to fly from Santo Domingo to Panama City?

The fastest flights from Santo Domingo to Panama City start from 8 hours 49 minutes in the air.

Which airline can fly direct from Santo Domingo to Panama City?

The following airlines operate direct flights on the route Santo Domingo — Panama City: Copa Airlines

Special offers and sales on air tickets from Santo Domingo to Panama City

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

We couldn't find any special offers for flights from Santo Domingo to Panama City

Alternative routes

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Cheapest one way flight

$231

Avianca

1 transfer

13h 40m

11/18/2025

The cheapest one-way flight from Santo Domingo to Panama City departs on 11/18/2025, is operated by Avianca and costs $231

Cheapest round trip flight

—

There is no information about the cheapest roundtrip flight from Santo Domingo to Panama City

The fastest flight