Compare airlines, prices, and flight durations for your trip
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santo Domingo to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
The minimum one-way ticket price from Santo Domingo to Panama City is $212 (February 2026), while the maximum is $402 (January 2026). On average, a ticket costs $307–$402.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santo Domingo to Panama City:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The route Santo Domingo — Panama City is served by several airlines: Copa Airlines, Asian Air, and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $231 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
Santo Domingo — Panama City
01/03/2026
Departure
Direct flight
CM464
starting at $709
Santo Domingo — Panama City
01/15/2026
Departure
Direct flight
CM464
starting at $626
Santo Domingo — Panama City
01/17/2026
Departure
Direct flight
CM464
starting at $727
Santo Domingo — Panama City
01/24/2026
Departure
Direct flight
CM299
starting at $606
Santo Domingo — Panama City
02/02/2026
Departure
Direct flight
CM464
starting at $688
Santo Domingo — Panama City
02/03/2026
Departure
Direct flight
CM464
starting at $676
Santo Domingo — Panama City
04/17/2026
Departure
Direct flight
CM464
starting at $604
Unable to find information about the schedule of direct flights from
The cheapest flight ticket from Santo Domingo to Panama City according to data for the last 48 hours costs $231
Often the best time to buy tickets from Santo Domingo to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Panama City can be found flying in these months: February, January.
The fastest flights from Santo Domingo to Panama City start from 5 hours 35 minutes in the air.
The following airlines operate direct flights on the route Santo Domingo — Panama City: Copa Airlines
We couldn't find any special offers for flights from Santo Domingo to Panama City
A non-stop flight is the most convenient and comfortable way to fly from Santo Domingo to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
The cheapest one-way flight from Santo Domingo to Panama City departs on 01/24/2026, is operated by Asian Air and costs $231
The cheapest roundtrip flight from Santo Domingo to Panama City departs on 04/01/2026, is operated by Copa Airlines and costs $567
Fastest flight from Santo Domingo to Panama City takes 5h 35m
There are no direct flights on this route.
The distance between Santo Domingo and Panama City is 1474km (914 miles). There are 34 direct flights from Santo Domingo to Panama City. The time difference between Santo Domingo and Panama City is 1h. Flights from Santo Domingo begin at 6:00 AM. The latest flight from Santo Domingo departs at 6:43 PM
