There are most likely no direct flights on the Santo Domingo — Panama City route
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The minimum one-way ticket price from Santo Domingo to Panama City is $247 (June 2026), while the maximum is $264 (October 2026). On average, a ticket costs $256–$264.
A non-stop flight is the most convenient and comfortable way to fly from Santo Domingo to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Santo Domingo — Panama City route
Santo Domingo — Panama City
06/27/2026
Departure
Direct flight
CM464
starting at $754
Santo Domingo — Panama City
06/28/2026
Departure
Direct flight
CM108
starting at $728
Santo Domingo — Panama City
07/03/2026
Departure
Direct flight
CM129
starting at $719
Santo Domingo — Panama City
07/04/2026
Departure
Direct flight
CM464
starting at $727
Santo Domingo — Panama City
08/11/2026
Departure
Direct flight
CM129
starting at $727
Santo Domingo — Panama City
11/14/2026
Departure
Direct flight
CM267
starting at $638
Santo Domingo — Panama City
11/15/2026
Departure
Direct flight
CM299
starting at $701
Santo Domingo — Panama City
11/16/2026
Departure
Direct flight
CM129
starting at $640
Santo Domingo — Panama City
11/17/2026
Departure
Direct flight
CM299
starting at $696
The route Santo Domingo — Panama City is served by several airlines: Copa Airlines, Avianca, and Asian Air. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $236 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Santo Domingo to Panama City according to data for the last 48 hours costs $236
Often the best time to buy tickets from Santo Domingo to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Panama City can be found flying in these months: June, October.
The fastest flights from Santo Domingo to Panama City start from 5 hours 35 minutes in the air.
The following airlines operate direct flights on the route Santo Domingo — Panama City: Copa Airlines
The cheapest one-way flight from Santo Domingo to Panama City departs on 07/03/2026, is operated by Avianca and costs $236
There is no information about the cheapest roundtrip flight from Santo Domingo to Panama City
Fastest flight from Santo Domingo to Panama City takes 5h 35m
There are direct flights on this route 5 days a week: Su, Mo, Tu, Fr, and Sa
The distance between Santo Domingo and Panama City is 1474km (914 miles). There are 14 direct flights from Santo Domingo to Panama City. The time difference between Santo Domingo and Panama City is 1h. Flights from Santo Domingo begin at 6:04 AM. The latest flight from Santo Domingo departs at 6:39 PM
We couldn't find any special offers for flights from Santo Domingo to Panama City
