Copa Airlines
Every day
starting at $285
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santo Domingo to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Santo Domingo to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
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The price trend from Santo Domingo to Panama City resembles a smile: costs drop, bottom out, then recover. Knowing this, you can pick dates with the best prices.
Prices fall from January 2027 to March 2027 (47%), then rise from November 2026 to January 2027 (+73%). The best period is January 2027–March 2027 ($459), the most expensive is November 2026–January 2027 ($475).
The best time to buy is January 2027–March 2027, when prices are at their lowest. This can save you up to 3% compared to the expensive months (November 2026–January 2027).
Monthly price variation is 30.1%. On this route, your departure date noticeably affects the cost, and choosing wisely can lead to real savings.
The minimum one-way ticket price from Santo Domingo to Panama City is $317 (March 2027), while the maximum is $601 (January 2027). On average, a ticket costs $422–$950.
Copa Airlines
Every day
starting at $285
The only airline operating direct flights from Santo Domingo to Panama City is Copa Airlines. Flights operate every day.
Santo Domingo — Panama City
12/05/2026
Departure
Direct flight
CM888
starting at $565
Santo Domingo — Panama City
01/26/2027
Departure
Direct flight
CM299
starting at $572
Santo Domingo — Panama City
01/27/2027
Departure
Direct flight
CM267
starting at $640
Santo Domingo — Panama City
03/31/2027
Departure
Direct flight
CM129
starting at $664
Santo Domingo — Panama City
11/14/2026
Departure
Direct flight
CM299
starting at $376
starting at $376
starting at $314
The route Santo Domingo — Panama City is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $314 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Santo Domingo to Panama City according to data for the last 48 hours costs $314
Often the best time to buy tickets from Santo Domingo to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Panama City can be found flying in these months: March, November, January.
The fastest flights from Santo Domingo to Panama City start from 6 hours 45 minutes in the air.
The following airlines operate direct flights on the route Santo Domingo — Panama City: Copa Airlines
The cheapest one-way flight from Santo Domingo to Panama City departs on 11/14/2026, is operated by Avianca and costs $314
The cheapest roundtrip flight from Santo Domingo to Panama City departs on 11/13/2026, is operated by Avianca and costs $493
Fastest flight from Santo Domingo to Panama City takes 6h 45m
There are direct flights on this route 3 days a week: Tu, We, and Sa
The distance between Santo Domingo and Panama City is 1477km (916 miles). There are 40 direct flights from Santo Domingo to Panama City. The time difference between Santo Domingo and Panama City is 1h. Flights from Santo Domingo begin at 6:07 AM. The latest flight from Santo Domingo departs at 6:42 PM
We couldn't find any special offers for flights from Santo Domingo to Panama City