A direct flight is the most convenient and comfortable way to fly from Santo Domingo to Medellin, despite the fact that sometimes flights with transfers can cost significantly less.
Schedule of direct flights from Santo Domingo to Medellin
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santo Domingo to Medellin:
Santo Domingo airports overview
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Medellin airports overview
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Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Santo Domingo to Medellin
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$105
Asian Air
Direct flight
2h 32m
02/07/2026
The cheapest one-way flight from Santo Domingo to Medellin departs on 02/07/2026, is operated by Asian Air and costs $105
Cheapest round trip flight
$265
Asian Air
Direct flight
5h 4m
01/16/2026
The cheapest roundtrip flight from Santo Domingo to Medellin departs on 01/16/2026, is operated by Asian Air and costs $265
The fastest flight
2h 32m
Fastest flight from Santo Domingo to Medellin takes 2h 32m
Direct flights
Once a week
There are direct flights on this route 1 day a week: Sa
Earliest flight
6:00 AM
Latest flight
7:07 PM
Direct flights count
19
Distance
1492km
Timezone difference
1h
The distance between Santo Domingo and Medellin is 1492km (925 miles). There are 19 direct flights from Santo Domingo to Medellin. The time difference between Santo Domingo and Medellin is 1h. Flights from Santo Domingo begin at 6:00 AM. The latest flight from Santo Domingo departs at 7:07 PM
February 2026
Lowest price
on average:
$105
Avg Price
The route Santo Domingo — Medellin is served by a single airline — Asian Air. This means that when planning your trip, you won’t need to spend time choosing between dozens of carriers: all flights are operated by one provider, which simplifies the booking process. Despite the limited choice, passengers can still plan ahead, select optimal departure dates, and buy tickets at the lowest price — from $105. Using our service, you can quickly compare available Asian Air flights and book a seat in advance at a favorable rate.
We couldn't find any special offers for flights from Santo Domingo to Medellin
How much is the cheapest flight ticket from Santo Domingo to Medellin?
The cheapest flight ticket from Santo Domingo to Medellin according to data for the last 48 hours costs $105
When is the best time to buy air tickets on the route Santo Domingo — Medellin?
Often the best time to buy tickets from Santo Domingo to Medellin is 2 months before departure.
When is the cheapest time of year to fly from Santo Domingo to Medellin?
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Medellin can be found flying in these months: February.
How long does it take to fly from Santo Domingo to Medellin?
The fastest flights from Santo Domingo to Medellin start from 2 hours 32 minutes in the air.
Which airline can fly direct from Santo Domingo to Medellin?
The following airlines operate direct flights on the route Santo Domingo — Medellin: Asian Air
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Santo Domingo to Medellin
