Unable to find information about the schedule of direct flights from
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We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Santiago to Panama City
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Panama City:
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Answers to questions about the route that travelers are most interested in.
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Unable to find information about the schedule of direct flights from
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santiago to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Santiago to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
Santiago — Panama City
02/16/2026
Departure
Direct flight
CM483
starting at $612
Santiago — Panama City
04/09/2026
Departure
Direct flight
CM483
starting at $542
starting at $542
starting at $309
The Santiago — Panama City route is served by multiple airlines, including Copa Airlines and Spirit Airlines. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $309, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
The cheapest flight ticket from Santiago to Panama City according to data for the last 48 hours costs $309
Often the best time to buy tickets from Santiago to Panama City is 2 months before departure.
The fastest flights from Santiago to Panama City start from 6 hours 27 minutes in the air.
The following airlines operate direct flights on the route Santiago — Panama City: Copa Airlines
The cheapest one-way flight from Santiago to Panama City departs on 04/09/2026, is operated by Spirit Airlines and costs $309
There is no information about the cheapest roundtrip flight from Santiago to Panama City
Fastest flight from Santiago to Panama City takes 1d 6h 27m
There are direct flights on this route 2 days a week: Mo and Th
The distance between Santiago and Panama City is 1503km (932 miles). There are 4 direct flights from Santiago to Panama City. The time difference between Santiago and Panama City is 1h. Flights from Santiago begin at 3:51 PM. The latest flight from Santiago departs at 3:51 PM
We couldn't find any special offers for flights from Santiago to Panama City