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Fly from Santiago to São Paulo with confidence — our search scans over 700 airlines, 50+ agencies and 5+ top booking systems to uncover the best prices, schedules and travel conditions for your trip. Compare options in seconds and book the flight that matches your budget and timing with ease.
Fly direct from Santiago to São Paulo for the quickest, most comfortable way to bridge Chile and Brazil—no layovers, less hassle, and more time on the ground enjoying your destination. While connecting options can sometimes be cheaper, a nonstop route saves hours and reduces travel stress, making it a smart choice for business trips or short getaways—check fares now to find the best direct option.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Sao Paulo:
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More than 7 airlines operate flights from Santiago to Sao Paulo, including Sky Airline, LATAM Chile, LATAM Paraguay, Aerolineas Argentinas, B&H Airlines, Gol Transportes Aéreos, and Avianca. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $91, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
starting at $91
starting at $92
starting at $102
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starting at $128
starting at $280
starting at $672
Santiago — Sao Paulo
03/11/2026
Departure
Direct flight
H2610
starting at $91
Santiago — Sao Paulo
02/25/2026
Departure
Direct flight
H2610
starting at $93
Santiago — Sao Paulo
03/22/2026
Departure
Direct flight
H2610
starting at $94
Santiago — Sao Paulo
03/22/2026
Departure
Direct flight
LA607
starting at $106
Santiago — Sao Paulo
03/23/2026
Departure
Direct flight
LA632
starting at $106
Santiago — Sao Paulo
04/09/2026
Departure
Direct flight
LA762
starting at $107
Santiago — Sao Paulo
03/09/2026
Departure
Direct flight
LA604
starting at $109
Santiago — Sao Paulo
02/21/2026
Departure
Direct flight
H2610
starting at $117
Santiago — Sao Paulo
03/16/2026
Departure
Direct flight
H2610
starting at $125
Santiago — Sao Paulo
03/13/2026
Departure
Direct flight
H2610
starting at $125
LATAM Chile
Every day
starting at $186
Sky Airline
Every day
starting at $136
Turkish Airlines
Su, Tu, Th, and Fr
starting at $195
Arturo Merino Benítez Airport (SCL) is Santiago’s main international gateway and typically functions as a full-service hub for LATAM and other legacy carriers, while also handling a growing number of low-cost and regional flights. Located about 15–20 km northwest of downtown, travel time is usually 20–40 minutes by car depending on traffic; airport buses and shared shuttles can take 30–60 minutes and typically cost in the low single-digit to low double-digit USD-equivalent range. Ride-hailing and taxis are widely available for faster but pricier transfers. Pros: broad international connectivity, modern facilities and frequent scheduled services; cons: peak-hour congestion and longer transit times to central Santiago can be factors to weigh.
São Paulo is served mainly by three airports, each playing a distinct role. São Paulo–Guarulhos International (GRU) is the primary international hub, handling most long-haul and full-service carriers; it’s about 25–30 km from downtown São Paulo and typically reachable in 30–60 minutes by airport bus, taxi or app ride (fares vary widely), or by the commuter rail + airport bus combination for lower cost. Congonhas (CGH) functions as the city’s domestic/business gateway for short-haul flights and legacy carriers, sitting roughly 8–9 km from the center — a taxi or ride-share often takes 20–40 minutes depending on traffic, while buses offer cheaper if slower options. Viracopos (VCP), near Campinas and farther out (around 90–110 km from São Paulo), can be a lower-cost or cargo-focused alternative used by some international budget or charter services; coach transfers and regional buses connect it to the city in about 90–120 minutes. Pros: GRU offers extensive international connections and amenities; Congonhas is convenient for central access and business travel; Viracopos may yield cheaper fares or less congestion. Cons: GRU can be far and busy during peak times; Congonhas is subject to heavy road traffic; Viracopos involves a long ground transfer. Typical transport fares range from budget shuttle/bus options to higher taxi/app prices, so travelers often balance cost versus door-to-door time.
The cheapest flight ticket from Santiago to Sao Paulo according to data for the last 48 hours costs $91
Often the best time to buy tickets from Santiago to Sao Paulo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Sao Paulo can be found flying in these months: April, October, February.
The fastest flights from Santiago to Sao Paulo start from 3 hours 50 minutes in the air.
The following airlines operate direct flights on the route Santiago — Sao Paulo: Sky Airline, LATAM Chile
The cost of a one-way flight from Santiago to Sao Paulo ranges from $128 (April 2026) to $659 (December 2026). On average, the ticket price is about $131–$202.
The cheapest one-way flight from Santiago to Sao Paulo departs on 03/11/2026, is operated by Sky Airline and costs $91
The cheapest roundtrip flight from Santiago to Sao Paulo departs on 04/10/2026, is operated by LATAM Chile and costs $183
Fastest flight from Santiago to Sao Paulo takes 3h 50m
There are direct flights on this route 6 days a week: Su, Mo, We, Th, Fr, and Sa
The distance between Santiago and Sao Paulo is 2566km (1591 miles). The average flight duration is 4h. There are 91 direct flights from Santiago to Sao Paulo. The time difference between Santiago and Sao Paulo is 1h. Flights from Santiago begin at 6:05 AM. The latest flight from Santiago departs at 1:40 AM