Cheap Flights from Santiago to Mexico City Starting at $237

Helping travelers to find the best flight offers

Cheapest flights from Santiago to Mexico City

Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santiago to Mexico City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.

Cheapest one way flight

$237

Sky Airline
Sky Airline
1 transfer
15h 10m
04/16/2025

The cheapest one-way flight from Santiago to Mexico City departs on 04/16/2025, is operated by Sky Airline and costs $237

Cheapest round trip flight

$635

Sky Airline
Sky Airline
1 transfer
1d 4h 40m
12/27/2025

The cheapest roundtrip flight from Santiago to Mexico City departs on 12/27/2025, is operated by Sky Airline and costs $635

The fastest flight

15h 10m

Fastest flight from Santiago to Mexico City takes 15h 10m

Direct flights

No direct flights

There are no direct flights on this route.

Earliest flight

9:10 AM

Latest flight

11:20 PM

Direct flights count

15

Distance

6611km

Timezone difference

2h

The distance between Santiago and Mexico City is 6611km (4099 miles). There are 15 direct flights from Santiago to Mexico City. The time difference between Santiago and Mexico City is 2h . Flights from Santiago begin at 9:10 AM. The latest flight from Santiago departs at 11:20 PM.

Airfare from Santiago to Mexico City by month

March 2025
Lowest price
on average:
$328
July 2025
Highest price
on average:
$376

Airlines operating on route

Starting at $580

Starting at $321

Starting at $370

Direct Flights from Santiago to Mexico City

A direct flight is the most convenient and comfortable way to fly from Santiago to Mexico City, despite the fact that sometimes flights with transfers can cost significantly less.

Schedule of direct flights from Santiago to Mexico City

A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Mexico City:

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Unable to find information about the schedule of direct flights from

Santiago airports overview

SCL
+2
Copa Airlines
B&H Airlines
Sky Airline
Airlines flying to this airport
$321
Starting at
$712
on average

Mexico City airports overview

TLC
Sky Airline
Airlines flying to this airport
$328
Starting at
$328-68%
on average
MEX
+2
Asian Air
B&H Airlines
Sky Airline
Airlines flying to this airport
$285
Starting at
$551
on average

Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

Special offers and sales on air tickets from Santiago to Mexico City

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

Alternative routes

San RafaelMexico CityConcepcionMexico CityLa RiojaMexico CityVina del MarMexico CityLa SerenaMexico CityMendozaMexico CityRio CuartoMexico CityMerloMexico CitySan JuanMexico CityTemucoMexico CitySantiagoAguascalientesSantiagoGuadalajaraSantiagoMoreliaSantiagoOaxacaSantiagoPueblaSantiagoQueretaroSantiagoSan Luis PotosiSantiagoTampicoSantiagoUruapanSantiagoVeracruz