There are most likely no direct flights on the Santiago — Mexico City route
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A non-stop flight is the most convenient and comfortable way to fly from Santiago to Mexico City, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Santiago — Mexico City route
Santiago — Mexico City
09/06/2026
Departure
Direct flight
LA622
starting at $1,028
Santiago — Mexico City
09/16/2026
Departure
Direct flight
LA622
starting at $719
Santiago — Mexico City
10/01/2026
Departure
Direct flight
EB622
starting at $727
Santiago — Mexico City
10/02/2026
Departure
Direct flight
EB622
starting at $723
Santiago — Mexico City
10/30/2026
Departure
Direct flight
AM11
starting at $922
Santiago — Mexico City
11/20/2026
Departure
Direct flight
LA622
starting at $348
Santiago — Mexico City
11/22/2026
Departure
Direct flight
AM11
starting at $440
Santiago — Mexico City
11/22/2026
Departure
Direct flight
LA622
starting at $476
Santiago — Mexico City
11/24/2026
Departure
Direct flight
AM11
starting at $382
Santiago — Mexico City
11/25/2026
Departure
Direct flight
AM11
starting at $335
starting at $348
starting at $723
starting at $328
starting at $337
starting at $347
starting at $351
starting at $375
The route Santiago — Mexico City is served by many carriers — 7 in total, including LATAM Chile, Wamos Air, Aeromexico, Sky Airline, B&H Airlines, Copa Airlines, and Asian Air. This gives passengers wide opportunities: from finding the lowest fare (from $328) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
The cheapest one-way flight from Santiago to Mexico City departs on 11/21/2026, is operated by Aeromexico and costs $328
The cheapest roundtrip flight from Santiago to Mexico City departs on 12/12/2026, is operated by Aeromexico and costs $535
Fastest flight from Santiago to Mexico City takes 8h 45m
There are direct flights on this route 6 days a week: Su, Tu, We, Th, Fr, and Sa
The distance between Santiago and Mexico City is 6608km (4097 miles). There are 8 direct flights from Santiago to Mexico City. The time difference between Santiago and Mexico City is 2h. Flights from Santiago begin at 8:30 AM. The latest flight from Santiago departs at 8:30 AM
The cheapest flight ticket from Santiago to Mexico City according to data for the last 48 hours costs $328
Often the best time to buy tickets from Santiago to Mexico City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Mexico City can be found flying in these months: January, October, December.
The fastest flights from Santiago to Mexico City start from 8 hours 45 minutes in the air.
The following airlines operate direct flights on the route Santiago — Mexico City: LATAM Chile, Wamos Air, Aeromexico
In different months, ticket prices from Santiago to Mexico City vary: minimum — $322 (January 2027), maximum — $401 (September 2026). Typically, the flight costs $362–$371.
Tickets from Santiago to Mexico City cost roughly the same any month. This is convenient: you can plan your trip based on your schedule rather than prices.
There is a slight difference: it's a bit cheaper in December 2026–January 2027 (averaging $346) and slightly more in September 2026–October 2026 ($378). But overall, the difference is small.
On this route, you don't need to target specific months — prices are stable. The difference between the cheapest and most expensive period is only 8%. Book whenever it's convenient.
Monthly price variation is just 7.9%. Ticket costs on this route are among the most predictable.
Comodoro Arturo Merino Benítez Airport (SCL) is Santiago’s main international gateway and typically serves as Chile’s primary hub for full-service carriers and many long-haul flights, while also handling some low-cost operators. It sits about 15–20 km northwest of downtown Santiago; road transfer by taxi or rideshare can take roughly 20–40 minutes depending on traffic, with airport buses and shared shuttles usually offering cheaper options in the 30–90 minute range overall. A suburban metro extension and bus connections provide budget-friendly access, though transfer times vary. Pros: comprehensive facilities, many international connections and frequent airline choices. Cons: can be busy during peak hours and traffic to the city can be unpredictable.
We couldn't find any special offers for flights from Santiago to Mexico City
Mexico City’s main gateway is Benito Juárez International Airport (MEX), the country’s primary international hub handling a mix of full-service and low-cost carriers; it typically serves most long-haul and domestic flights. Located about 8–13 km east of the historic center, travel times to downtown can range from 20–60 minutes depending on traffic. Options include the metro (Line 5 and transfer connections) and the newer airport bus and Aerotren links, with fares usually low to moderate, while taxis and rideshares are faster but can cost more. Pros: extensive connections and amenities; cons: can be crowded and subject to traffic delays during peak hours. There are also smaller general-aviation fields and military airbases around the metropolitan area for private or charter operations.
