Cheap Flights from Santiago to Mexico City Starting at $256
Helping travelers to find the best flight offers
Cheapest flights from Santiago to Mexico City
Fly from Santiago to Mexico City with confidence — our search checks over 700 airlines, 50+ agencies and more than 5 top booking systems to uncover the best prices, schedules and booking conditions for your trip. Compare nonstop and connecting options in seconds and lock in the deal that suits your budget and timing.
Remember that on average the ideal time to book flights is 2 months before departure!
Fly nonstop from Santiago to Mexico City for the quickest, most convenient way to bridge South and Central America — arrive sooner and skip the hassle of layovers. While you may sometimes find cheaper connecting options, a direct flight saves hours and keeps your trip more comfortable, making it a smart choice for business or leisure travel.
Schedule of direct flights from Santiago to Mexico City
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Mexico City:
Santiago airports overview
Mexico City airports overview
Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Santiago to Mexico City
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
•••••••••••••••••••
Cheapest one way flight
$256
Avianca
1 transfer
13h 35m
11/03/2025
The cheapest one-way flight from Santiago to Mexico City departs on 11/03/2025, is operated by Avianca and costs $256
Cheapest round trip flight
$511
Avianca
1 transfer
1d 16h
11/09/2025
The cheapest roundtrip flight from Santiago to Mexico City departs on 11/09/2025, is operated by Avianca and costs $511
The fastest flight
13h 35m
Fastest flight from Santiago to Mexico City takes 13h 35m
Direct flights
No direct flights
There are no direct flights on this route.
Earliest flight
8:20 AM
Latest flight
8:20 AM
Direct flights count
8
Distance
6611km
Timezone difference
2h
The distance between Santiago and Mexico City is 6611km (4099 miles). There are 8 direct flights from Santiago to Mexico City. The time difference between Santiago and Mexico City is 2h. Flights from Santiago begin at 8:20 AM. The latest flight from Santiago departs at 8:20 AM
The route Santiago — Mexico City is served by many carriers — 4 in total, including LATAM Chile, Aeromexico, Avianca, and Copa Airlines. This gives passengers wide opportunities: from finding the lowest fare (from $256) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
Unable to find information about the schedule of direct flights from
Comodoro Arturo Merino Benítez Airport (SCL) is Santiago’s main international gateway and typically serves as Chile’s primary hub for full-service carriers and many long-haul flights, while also handling some low-cost operators. It sits about 15–20 km northwest of downtown Santiago; road transfer by taxi or rideshare can take roughly 20–40 minutes depending on traffic, with airport buses and shared shuttles usually offering cheaper options in the 30–90 minute range overall. A suburban metro extension and bus connections provide budget-friendly access, though transfer times vary. Pros: comprehensive facilities, many international connections and frequent airline choices. Cons: can be busy during peak hours and traffic to the city can be unpredictable.
Mexico City’s main gateway is Benito Juárez International Airport (MEX), the country’s primary international hub handling a mix of full-service and low-cost carriers; it typically serves most long-haul and domestic flights. Located about 8–13 km east of the historic center, travel times to downtown can range from 20–60 minutes depending on traffic. Options include the metro (Line 5 and transfer connections) and the newer airport bus and Aerotren links, with fares usually low to moderate, while taxis and rideshares are faster but can cost more. Pros: extensive connections and amenities; cons: can be crowded and subject to traffic delays during peak hours. There are also smaller general-aviation fields and military airbases around the metropolitan area for private or charter operations.
We couldn't find any special offers for flights from Santiago to Mexico City
November 2025
Lowest price
on average:
$258
December 2025
Highest price
on average:
$348
Avg Price
How much is the cheapest flight ticket from Santiago to Mexico City?
The cheapest flight ticket from Santiago to Mexico City according to data for the last 48 hours costs $256
When is the best time to buy air tickets on the route Santiago — Mexico City?
Often the best time to buy tickets from Santiago to Mexico City is 2 months before departure.
When is the cheapest time of year to fly from Santiago to Mexico City?
Based on statistics over the past years, the lowest prices for flights from Santiago to Mexico City can be found flying in these months: November, October, January.
How long does it take to fly from Santiago to Mexico City?
The fastest flights from Santiago to Mexico City start from 13 hours 35 minutes in the air.
Which airline can fly direct from Santiago to Mexico City?
The following airlines operate direct flights on the route Santiago — Mexico City: LATAM Chile, Aeromexico
In different months, ticket prices from Santiago to Mexico City vary: minimum — $258 (November 2025), maximum — $348 (December 2025). Typically, the flight costs $284–$290.
