Airlines operating on route
Below you will find a list of airlines operating flights on the Panama City — Santo Domingo route and the starting prices for flights of each specific airline on it.
Starting at $255
Helping travelers to find the best flight offers
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Panama City to Santo Domingo. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Panama City to Santo Domingo
Below you will find a list of airlines operating flights on the Panama City — Santo Domingo route and the starting prices for flights of each specific airline on it.
Starting at $255
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Santo Domingo:
Unable to find information about the schedule of direct flights from
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The cheapest one-way flight from Panama City to Santo Domingo departs on 04/23/2025, is operated by Avianca and costs $176
The cheapest roundtrip flight from Panama City to Santo Domingo departs on 05/02/2025, is operated by Avianca and costs $310
Fastest flight from Panama City to Santo Domingo takes 5h 10m
There are no direct flights on this route.
The distance between Panama City and Santo Domingo is 1474km (914 miles). There are 35 direct flights from Panama City to Santo Domingo. The time difference between Panama City and Santo Domingo is 1h . Flights from Panama City begin at 7:26 AM. The latest flight from Panama City departs at 11:13 PM.
Panama City — Santo Domingo
04/23/2025
Departure date
Direct flight
CM268
Starting at $585
Panama City — Santo Domingo
06/03/2025
Departure date
Direct flight
CM107
Starting at $583
The cheapest flight ticket from Panama City to Santo Domingo according to data for the last 48 hours costs $176
Often the best time to buy tickets from Panama City to Santo Domingo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Santo Domingo can be found flying in these months: April, May, October.
The fastest flights from Panama City to Santo Domingo start from 5 hours 10 minutes in the air.
The following airlines operate direct flights on the route Panama City — Santo Domingo: Copa Airlines
A direct flight is the most convenient and comfortable way to fly from Panama City to Santo Domingo, despite the fact that sometimes flights with transfers can cost significantly less.
We couldn't find any special offers for flights from Panama City to Santo Domingo
