There are most likely no direct flights on the Panama City — Santo Domingo route
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Panama City to Santo Domingo. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
The minimum one-way ticket price from Panama City to Santo Domingo is $324 (September 2026), while the maximum is $420 (December 2026). On average, a ticket costs $357–$748.
A non-stop flight is the most convenient and comfortable way to fly from Panama City to Santo Domingo, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Prices on the Panama City — Santo Domingo route are consistently going up. From September 2026 to December 2026, tickets went from $324 to $420 — a 30% increase. This trend is worth considering when planning your trip.
The most significant price increase was from September 2026 to December 2026 — up 30%. The best time to fly is September 2026–October 2026, when the average price is $326. In October 2026–December 2026, tickets cost around $374.
Given the rising prices, it's best not to delay your purchase. Flying in September 2026–October 2026 can save you up to 13% compared to the most expensive months.
Price variation across months on this route is 12.5%. Your choice of departure month significantly affects the total flight cost.
There are most likely no direct flights on the Panama City — Santo Domingo route
Panama City — Santo Domingo
09/12/2026
Departure
Direct flight
CM268
starting at $580
Panama City — Santo Domingo
09/13/2026
Departure
Direct flight
CM107
starting at $455
Panama City — Santo Domingo
09/15/2026
Departure
Direct flight
CM463
starting at $560
Panama City — Santo Domingo
09/23/2026
Departure
Direct flight
CM298
starting at $691
Panama City — Santo Domingo
09/24/2026
Departure
Direct flight
CM463
starting at $565
Panama City — Santo Domingo
09/26/2026
Departure
Direct flight
CM268
starting at $695
Panama City — Santo Domingo
10/04/2026
Departure
Direct flight
CM463
starting at $702
Panama City — Santo Domingo
10/10/2026
Departure
Direct flight
CM298
starting at $572
Panama City — Santo Domingo
10/11/2026
Departure
Direct flight
CM463
starting at $697
Panama City — Santo Domingo
10/13/2026
Departure
Direct flight
CM107
starting at $578
starting at $324
starting at $420
The route Panama City — Santo Domingo is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $324 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Panama City to Santo Domingo according to data for the last 48 hours costs $324
Often the best time to buy tickets from Panama City to Santo Domingo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Santo Domingo can be found flying in these months: September, October, December.
The fastest flights from Panama City to Santo Domingo start from 2 hours 31 minutes in the air.
The following airlines operate direct flights on the route Panama City — Santo Domingo: Copa Airlines
The cheapest one-way flight from Panama City to Santo Domingo departs on 09/25/2026, is operated by Copa Airlines and costs $324
The cheapest roundtrip flight from Panama City to Santo Domingo departs on 10/12/2026, is operated by Avianca and costs $533
Fastest flight from Panama City to Santo Domingo takes 2h 31m
There are direct flights on this route 5 days a week: Su, Tu, We, Th, and Sa
The distance between Panama City and Santo Domingo is 1477km (916 miles). There are 41 direct flights from Panama City to Santo Domingo. The time difference between Panama City and Santo Domingo is 1h. Flights from Panama City begin at 7:24 AM. The latest flight from Panama City departs at 10:55 PM
We couldn't find any special offers for flights from Panama City to Santo Domingo