Copa Airlines
Every day
starting at $497
Compare airlines, prices, and flight durations for your trip
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Panama City to Santo Domingo
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Santo Domingo:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Copa Airlines
Every day
starting at $497
Looking for cheap flights from Panama City to Santo Domingo? Look no further! At our air tickets search website, we offer the best deals on flights to Santo Domingo from Panama City. Explore the vibrant culture and rich history of the Dominican Republic without breaking the bank. With our user-friendly search engine, you can easily find the most affordable airfare options for your desired travel dates. Whether you're planning a weekend getaway or a longer vacation, our website provides a convenient way to compare prices from various airlines, ensuring you get the best value for your money. Book your flight today and start your adventure in Santo Domingo! Don't miss out on these incredible savings. Search for your Panama City to Santo Domingo air tickets now and enjoy a budget-friendly journey.
Panama City — Santo Domingo
01/22/2026
Departure
Direct flight
CM298
starting at $540
Panama City — Santo Domingo
03/30/2026
Departure
Direct flight
CM463
starting at $602
starting at $540
starting at $241
The route Panama City — Santo Domingo is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $241 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Panama City to Santo Domingo according to data for the last 48 hours costs $241
Often the best time to buy tickets from Panama City to Santo Domingo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Santo Domingo can be found flying in these months: January.
The fastest flights from Panama City to Santo Domingo start from 6 hours 5 minutes in the air.
The following airlines operate direct flights on the route Panama City — Santo Domingo: Copa Airlines
The cheapest one-way flight from Panama City to Santo Domingo departs on 03/31/2026, is operated by Avianca and costs $241
The cheapest roundtrip flight from Panama City to Santo Domingo departs on 02/23/2026, is operated by Avianca and costs $425
Fastest flight from Panama City to Santo Domingo takes 6h 5m
There are direct flights on this route 2 days a week: Mo and Th
The distance between Panama City and Santo Domingo is 1474km (914 miles). There are 35 direct flights from Panama City to Santo Domingo. The time difference between Panama City and Santo Domingo is 1h. Flights from Panama City begin at 7:28 AM. The latest flight from Panama City departs at 10:55 PM
A non-stop flight is the most convenient and comfortable way to fly from Panama City to Santo Domingo, despite the fact that sometimes flights with transfers can cost significantly less.
We couldn't find any special offers for flights from Panama City to Santo Domingo