Airfare from Panama City to Santo Domingo by month
The minimum one-way ticket price from Panama City to Santo Domingo is $258 (November 2025), while the maximum is $270 (March 2026). On average, a ticket costs $262–$263.
Airlines operating on route
Direct Flights from Panama City to Santo Domingo
A direct flight is the most convenient and comfortable way to fly from Panama City to Santo Domingo, despite the fact that sometimes flights with transfers can cost significantly less.
Schedule of direct flights from Panama City to Santo Domingo
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Santo Domingo:
Panama City airports overview
Santo Domingo airports overview
Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Panama City to Santo Domingo
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$251
Avianca
1 transfer
12h 55m
01/18/2026
The cheapest one-way flight from Panama City to Santo Domingo departs on 01/18/2026, is operated by Avianca and costs $251
Cheapest round trip flight
$459
Avianca
1 transfer
14h 20m
12/23/2025
The cheapest roundtrip flight from Panama City to Santo Domingo departs on 12/23/2025, is operated by Avianca and costs $459
The fastest flight
6h 5m
Fastest flight from Panama City to Santo Domingo takes 6h 5m
Direct flights
No direct flights
There are no direct flights on this route.
Earliest flight
7:26 AM
Latest flight
11:13 PM
Direct flights count
37
Distance
1474km
Timezone difference
1h
The distance between Panama City and Santo Domingo is 1474km (914 miles). There are 37 direct flights from Panama City to Santo Domingo. The time difference between Panama City and Santo Domingo is 1h. Flights from Panama City begin at 7:26 AM. The latest flight from Panama City departs at 11:13 PM
November 2025
Lowest price
on average:
$258
March 2026
Highest price
on average:
$270
Avg Price
The route Panama City — Santo Domingo is served by several airlines: Avianca and American Airlines. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $251 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
There appear to be no direct flights from Panama City to Santo Domingo at this time.... Well, or something went wrong on our side and we couldn't find anything
Unable to find information about the schedule of direct flights from
How much is the cheapest flight ticket from Panama City to Santo Domingo?
The cheapest flight ticket from Panama City to Santo Domingo according to data for the last 48 hours costs $251
When is the best time to buy air tickets on the route Panama City — Santo Domingo?
Often the best time to buy tickets from Panama City to Santo Domingo is 2 months before departure.
When is the cheapest time of year to fly from Panama City to Santo Domingo?
Based on statistics over the past years, the lowest prices for flights from Panama City to Santo Domingo can be found flying in these months: November, October, December.
How long does it take to fly from Panama City to Santo Domingo?
The fastest flights from Panama City to Santo Domingo start from 6 hours 5 minutes in the air.
Which airline can fly direct from Panama City to Santo Domingo?
The following airlines operate direct flights on the route Panama City — Santo Domingo:
We couldn't find any special offers for flights from Panama City to Santo Domingo
