Cheap Flights from Panama City to Mexico City

Cheapest flights from Panama City to Mexico City

Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Panama City to Mexico City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.

Cheapest one way flight

$283

Copa Airlines

1 layover

21h 32m

11/10/2026

The cheapest one-way flight from Panama City to Mexico City departs on 11/10/2026, is operated by Copa Airlines and costs $283

Cheapest round trip flight

$390

Aeromexico

Direct flight

7h 50m

01/22/2027

The cheapest roundtrip flight from Panama City to Mexico City departs on 01/22/2027, is operated by Aeromexico and costs $390

The fastest flight

3h 47m

Fastest flight from Panama City to Mexico City takes 3h 47m

Direct flights

Several times a week

There are direct flights on this route 6 days a week: Mo, Tu, We, Th, Fr, and Sa

Earliest flight

9:25 AM

Latest flight

10:05 PM

Direct flights count

56

Distance

2407km

Timezone difference

1h

The distance between Panama City and Mexico City is 2407km (1492 miles). There are 56 direct flights from Panama City to Mexico City. The time difference between Panama City and Mexico City is 1h. Flights from Panama City begin at 9:25 AM. The latest flight from Panama City departs at 10:05 PM

Remember that on average the ideal time to book flights is 2 months before departure!

Airfare from Panama City to Mexico City by month

The minimum one-way ticket price from Panama City to Mexico City is $271 (October 2026), while the maximum is $343 (July 2027). On average, a ticket costs $297–$299.

October 2026

Lowest price

on average:

$271

July 2027

Highest price

on average:

$343

Avg Price

Price dynamics

Tickets from Panama City to Mexico City cost roughly the same any month. This is convenient: you can plan your trip based on your schedule rather than prices.

Cheaper and more expensive periods

There is a slight difference: it's a bit cheaper in October 2026–January 2027 (averaging $274) and slightly more in January 2027–July 2027 ($310). But overall, the difference is small.

Best time to buy

On this route, you don't need to target specific months — prices are stable. The difference between the cheapest and most expensive period is only 12%. Book whenever it's convenient.

Price predictability

Monthly price variation is just 9.5%. Ticket costs on this route are among the most predictable.

Airlines operating on route

The Panama City — Mexico City route is served by a wide range of airlines: 4 in total, including Aeromexico, Copa Airlines, Avianca, and TACA Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $283. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.

starting at $283

starting at $283

starting at $441

starting at $484

Non-stop flights from Panama City to Mexico City

A non-stop flight is the most convenient and comfortable way to fly from Panama City to Mexico City, despite the fact that sometimes flights with transfers can cost significantly less.

Panama City — Mexico City

PTY — MEX

11/09/2026

Departure

Direct flight

AM465

starting at $283

Panama City — Mexico City

PTY — MEX

11/13/2026

Departure

Direct flight

AM465

starting at $284

Panama City — Mexico City

PTY — MEX

01/12/2027

Departure

Direct flight

AM465

starting at $284

Panama City — Mexico City

PTY — MEX

01/13/2027

Departure

Direct flight

AM465

starting at $285

Panama City — Mexico City

PTY — MEX

01/14/2027

Departure

Direct flight

AM465

starting at $285

Panama City — Mexico City

PTY — MEX

12/01/2026

Departure

Direct flight

AM465

starting at $285

Panama City — Mexico City

PTY — MEX

12/02/2026

Departure

Direct flight

AM465

starting at $285

Panama City — Mexico City

PTY — MEX

11/03/2026

Departure

Direct flight

CM138

starting at $289

Panama City — Mexico City

PTY — MEX

11/07/2026

Departure

Direct flight

CM138

starting at $290

Panama City — Mexico City

PTY — MEX

10/07/2026

Departure

Direct flight

CM188

starting at $291

Schedule of direct flights from Panama City to Mexico City

There are most likely no direct flights on the Panama City — Mexico City route

Panama City airports overview

Marcos A. Gelabert International Airport

•

PAC

34km

Tocumen International Airport

•

PTY

17km

•

Mexico City airports overview

Benito Juarez International Airport

•

MEX

6km

Felipe Angeles International Airport

•

NLU

4km

Toluca International Airport

•

TLC

59km

•

Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

What is the cheapest price for flights from Panama City to Mexico City?

The cheapest flight ticket from Panama City to Mexico City according to data for the last 48 hours costs $283

When is the best time to buy air tickets on the route Panama City — Mexico City?

Often the best time to buy tickets from Panama City to Mexico City is 2 months before departure.

When is the cheapest time of year to fly from Panama City to Mexico City?

Based on statistics over the past years, the lowest prices for flights from Panama City to Mexico City can be found flying in these months: October, January, September.

How long does it take to fly from Panama City to Mexico City?

The fastest flights from Panama City to Mexico City start from 3 hours 47 minutes in the air.

Which airline can fly direct from Panama City to Mexico City?

The following airlines operate direct flights on the route Panama City — Mexico City: Aeromexico, Copa Airlines

Special offers and sales on air tickets from Panama City to Mexico City

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

We couldn't find any special offers for flights from Panama City to Mexico City

Alternative routes

Apartado ➜ Mexico City•Barranquilla ➜ Mexico City•Cartago ➜ Mexico City•Cartagena ➜ Mexico City•David ➜ Mexico City•Medellin ➜ Mexico City•Monteria ➜ Mexico City•Pereira ➜ Mexico City•Quibdo ➜ Mexico City•Panama City ➜ Aguascalientes•Panama City ➜ Guadalajara•Panama City ➜ Morelia•Panama City ➜ Oaxaca•Panama City ➜ Puebla•Panama City ➜ Queretaro•Panama City ➜ San Luis Potosi•Panama City ➜ Tampico•Panama City ➜ Uruapan•Panama City ➜ Veracruz

•••••••••••••••••••

Cheapest one way flight

$283

Copa Airlines

1 layover

21h 32m

11/10/2026

The cheapest one-way flight from Panama City to Mexico City departs on 11/10/2026, is operated by Copa Airlines and costs $283

Cheapest round trip flight

$390

Aeromexico

Direct flight

7h 50m

01/22/2027

The cheapest roundtrip flight from Panama City to Mexico City departs on 01/22/2027, is operated by Aeromexico and costs $390

The fastest flight