Cheap Flights from Panama City to Mexico City — $180

The Panama City — Mexico City route is served by a wide range of airlines: 4 in total, including Copa Airlines, Aeromexico, Avianca, and TACA Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $180. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.

Tocumen International Airport (PTY) is Panama City’s main international hub, handling most long-haul and connecting flights and serving carriers from legacy network airlines to regional and low-cost operators. Located about 24 km (15 miles) northeast of downtown, it’s typically reached by taxi, ride-share or airport shuttle in roughly 25–40 minutes depending on traffic; fares can vary but are usually comparable to other Latin American capitals. PTY offers a wide range of passenger services and connections, making it convenient for transfers, though peak-time crowds and occasional delays can affect comfort. Public buses and private transfers are cheaper alternatives but are slightly slower. Albrook “Marcos A. Gelabert” International Airport (PAC) functions mainly as Panama City’s domestic and regional airport, often used by local carriers and short-haul budget airlines. Situated roughly 3–4 km (about 2 miles) from the city center near the Albrook district, it’s typically a 10–15 minute taxi or ride-share trip and can be reached by city buses for a very low fare. PAC can be a good option for quick regional hops and lower-cost domestic travel, though facilities are smaller and flight options fewer than at Tocumen; security queues and limited international services are occasional drawbacks.

The distance between Panama City and Mexico City is 2407km (1492 miles). There are 39 direct flights from Panama City to Mexico City. The time difference between Panama City and Mexico City is 1h. Flights from Panama City begin at 9:19 AM. The latest flight from Panama City departs at 10:11 PM

The minimum one-way ticket price from Panama City to Mexico City is $180 (June 2026), while the maximum is $271 (November 2026). On average, a ticket costs $225–$271.

Mexico City is served mainly by Benito Juárez International (MEX), the country's primary international hub that handles a mix of full-service carriers and growing low-cost airlines; a new Felipe Ángeles Airport (NLU) north of the city is increasingly used for budget and domestic connections. Benito Juárez sits about 5–10 km east of downtown, typically reachable by taxi or ride-hailing in 20–40 minutes depending on traffic, and by metro/Metrobus in around 35–60 minutes with fares usually low-cost. Felipe Ángeles is roughly 40–50 km from the center, often taking 45–90 minutes by road; shuttle and bus services are available at modest fares. Pros: MEX offers extensive international connections and public transit links; NLU can be cheaper and less congested. Cons: both airports can face heavy traffic and longer transfer times, and services at peripheral terminals may be more basic.