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Fly from Panama City to Istanbul with confidence — our search scans over 700 airlines, more than 50 agencies and 5+ top booking systems to uncover the best fares, schedules and travel conditions for your trip. Compare options in seconds and secure the flight that matches your budget and itinerary, whether you prioritize price, connections or flexibility.
Fly nonstop from Panama City to Istanbul for the fastest, most convenient way to bridge Central America and Turkey — fewer hassles, no plane changes, and more time to enjoy the sights. While connecting options can sometimes be cheaper, a direct flight saves hours and provides a more comfortable, stress-free travel experience worth considering when planning your trip.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Istanbul:
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Answers to questions about the route that travelers are most interested in.
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More than 6 airlines operate flights from Panama City to Istanbul, including Turkish Airlines, Avianca, Copa Airlines, Condor, Air France, and United Airlines. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $542, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
starting at $716
starting at $542
starting at $553
starting at $587
starting at $602
starting at $641
Panama City — Istanbul
02/03/2026
Departure
Direct flight
TK904
starting at $2,754
Panama City — Istanbul
02/03/2026
Departure
Direct flight
TK900
starting at $4,180
Panama City — Istanbul
02/05/2026
Departure
Direct flight
TK904
starting at $2,750
Panama City — Istanbul
02/05/2026
Departure
Direct flight
TK801
starting at $3,653
Panama City — Istanbul
02/06/2026
Departure
Direct flight
TK800
starting at $3,169
Panama City — Istanbul
02/08/2026
Departure
Direct flight
TK904
starting at $1,273
Panama City — Istanbul
02/08/2026
Departure
Direct flight
TK800
starting at $2,340
Panama City — Istanbul
02/10/2026
Departure
Direct flight
TK904
starting at $1,395
Panama City — Istanbul
02/12/2026
Departure
Direct flight
TK904
starting at $1,253
Panama City — Istanbul
02/12/2026
Departure
Direct flight
TK801
starting at $2,380
Turkish Airlines
Every day
starting at $1,242
Tocumen International Airport (PTY) is Panama City’s main international hub and typically handles most long-haul and regional flights, including carriers like Copa Airlines and various global airlines. It’s about 24 km (roughly 30–45 minutes) from the historic center, with taxis, airport shuttles and private transfers as common options; fares can range from moderate to higher depending on time and service level, while the Metro Line 2 currently provides a budget-friendly rail link for parts of the route. Tocumen’s strengths are its broad connectivity and modern facilities, though peak hours can mean longer lines and transfers. For budget or domestic connections, smaller airports or regional terminals may be used but are generally secondary to PTY.
The cheapest one-way flight from Panama City to Istanbul departs on 05/05/2026, is operated by Avianca and costs $542
The cheapest roundtrip flight from Panama City to Istanbul departs on 02/04/2026, is operated by Avianca and costs $997
Fastest flight from Panama City to Istanbul takes 19h 15m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Panama City and Istanbul is 10850km (6727 miles). The average flight duration is 12h 45m. There are 9 direct flights from Panama City to Istanbul. The time difference between Panama City and Istanbul is 8h. Flights from Panama City begin at 6:45 PM. The latest flight from Panama City departs at 9:45 PM
The cheapest flight ticket from Panama City to Istanbul according to data for the last 48 hours costs $542
Often the best time to buy tickets from Panama City to Istanbul is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Istanbul can be found flying in these months: February, May, March.
The fastest flights from Panama City to Istanbul start from 19 hours 15 minutes in the air.
The following airlines operate direct flights on the route Panama City — Istanbul: Turkish Airlines
The cost of a one-way flight from Panama City to Istanbul ranges from $564 (February 2026) to $750 (August 2026). On average, the ticket price is about $656–$1,334.
Istanbul Airport (IST) is Turkey’s primary international hub and typically handles most long-haul and full-service carriers, along with many Star Alliance and SkyTeam flights. Located about 40–50 km northwest of the historic center, it can be reached by taxi in roughly 40–60 minutes depending on traffic; city bus and Havaist shuttles take about 60–90 minutes with fares usually in the mid-range for airport transfers. A metro connection provides a growing public-transport option. Pros: modern facilities, extensive international connections and ample services; cons: longer transfer times to central districts and potential congestion during peak hours. Sabiha Gökçen International Airport (SAW) on the Asian side serves many low-cost and regional carriers and is typically a budget-friendly alternative for domestic and near-regional routes. It sits approximately 35–45 km southeast of central European Istanbul and about 30–40 km from Kadıköy, with taxis taking roughly 45–75 minutes depending on traffic; Havatas/Havabus shuttles and municipal buses take about 60–90 minutes with generally lower fares than private transfers. Pros: often cheaper fares and closer access to the Asian side; cons: fewer long-haul connections and longer, less predictable road travel during rush hours.