Cheap Flights from Mexico City to Panama City — $231
Compare airlines, prices, and flight durations for your trip
Cheapest flights from Mexico City to Panama City
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Mexico City to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
Remember that on average the ideal time to book flights is 2 months before departure!
A non-stop flight is the most convenient and comfortable way to fly from Mexico City to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
Schedule of direct flights from Mexico City to Panama City
Mexico City airports overview
•
•
•
Panama City airports overview
•
•
•
Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Mexico City to Panama City
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
•••••••••••••••••••
Cheapest one way flight
$231
Air Ocean
1 layover
18h 40m
05/15/2026
The cheapest one-way flight from Mexico City to Panama City departs on 05/15/2026, is operated by Air Ocean and costs $231
Cheapest round trip flight
$449
Copa Airlines
Direct flight
7h 41m
06/12/2026
The cheapest roundtrip flight from Mexico City to Panama City departs on 06/12/2026, is operated by Copa Airlines and costs $449
The fastest flight
8h 20m
Fastest flight from Mexico City to Panama City takes 8h 20m
Direct flights
Several times a week
There are direct flights on this route 3 days a week: Su, Th, and Fr
Earliest flight
5:50 AM
Latest flight
2:10 AM
Direct flights count
7
Distance
2407km
Timezone difference
1h
The distance between Mexico City and Panama City is 2407km (1492 miles). There are 7 direct flights from Mexico City to Panama City. The time difference between Mexico City and Panama City is 1h. Flights from Mexico City begin at 5:50 AM. The latest flight from Mexico City departs at 2:10 AM
The Mexico City — Panama City route is served by multiple airlines, including Copa Airlines, Air Ocean, and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $231, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
Mexico City is primarily served by Benito Juárez International (MEX), the city’s main international hub that handles most full-service carriers and many low-cost airlines, and the newer Felipe Ángeles International (NLU), which mostly caters to budget and domestic flights. MEX sits close to the city center — about 15–20 km — with metro, airport shuttle buses, and taxis taking roughly 25–45 minutes depending on traffic; expect fares from modest metro prices up to mid-range taxi or ride-hail costs. NLU lies farther north (around 45–50 km), reachable by dedicated buses and longer taxi rides that typically take 50–90 minutes and can be cheaper on scheduled shuttles. Pros: MEX is convenient for business and international connections; NLU can offer lower fares and newer facilities. Cons: both can be affected by heavy traffic and peak-time congestion, and transfers between airports may add significant travel time.
Tocumen International (PTY) is Panama City’s primary international gateway and a major connecting hub for Latin America, typically serving full-service carriers like Copa Airlines alongside some international and regional carriers. Flights here can be priced competitively compared with secondary airports, though fares vary by route and season. The airport sits about 24–30 km (roughly 30–40 minutes without heavy traffic) east of downtown Panama City; taxis and ride‑hailing services are common (fares generally in the mid-range for the region), while airport shuttles and private transfers offer fixed-price options. Tocumen provides extensive amenities and smooth connections for onward travel, but the distance from the city center and occasional peak‑hour congestion can add time and cost to transfers. For low‑cost or domestic services, Marcos A. Gelabert Airport (PAC) near the city serves regional and budget flights, offering very short transfers into the city (10–20 minutes) and a simpler, more budget‑oriented experience.
Avg Price
What is the cheapest price for flights from Mexico City to Panama City?
The cheapest flight ticket from Mexico City to Panama City according to data for the last 48 hours costs $231
When is the best time to buy air tickets on the route Mexico City — Panama City?
Often the best time to buy tickets from Mexico City to Panama City is 2 months before departure.
How long does it take to fly from Mexico City to Panama City?
The fastest flights from Mexico City to Panama City start from 8 hours 20 minutes in the air.
Which airline can fly direct from Mexico City to Panama City?
The following airlines operate direct flights on the route Mexico City — Panama City: Copa Airlines
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Mexico City to Panama City
We couldn't find any special offers for flights from Mexico City to Panama City
