Compare airlines, prices, and flight durations for your trip
Fly from Mexico City to Panama City with confidence — our search scans over 700 airlines, 50+ agencies and more than 5 top booking systems to uncover the best prices, schedules and travel conditions for your trip. Compare nonstop and connecting options in seconds and book the ideal itinerary that fits your budget and timing.
Fly direct from Mexico City to Panama City for the fastest, most convenient way to link the heart of Mexico with Panama’s vibrant capital — fewer hassles, no layovers, and more time to enjoy your trip. While connecting options can sometimes be cheaper, a nonstop flight saves hours and delivers greater comfort, making it the smart choice for business travelers and vacationers alike.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Panama City:
•
•
•
•
•
•
Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Copa Airlines
Every day
starting at $359
Mexico City is primarily served by Benito Juárez International (MEX), the city’s main international hub that handles most full-service carriers and many low-cost airlines, and the newer Felipe Ángeles International (NLU), which mostly caters to budget and domestic flights. MEX sits close to the city center — about 15–20 km — with metro, airport shuttle buses, and taxis taking roughly 25–45 minutes depending on traffic; expect fares from modest metro prices up to mid-range taxi or ride-hail costs. NLU lies farther north (around 45–50 km), reachable by dedicated buses and longer taxi rides that typically take 50–90 minutes and can be cheaper on scheduled shuttles. Pros: MEX is convenient for business and international connections; NLU can offer lower fares and newer facilities. Cons: both can be affected by heavy traffic and peak-time congestion, and transfers between airports may add significant travel time.
In different months, ticket prices from Mexico City to Panama City vary: minimum — $151 (April 2026), maximum — $165 (March 2026). Typically, the flight costs $158–$165.
Tocumen International (PTY) is Panama City’s primary international gateway and a major connecting hub for Latin America, typically serving full-service carriers like Copa Airlines alongside some international and regional carriers. Flights here can be priced competitively compared with secondary airports, though fares vary by route and season. The airport sits about 24–30 km (roughly 30–40 minutes without heavy traffic) east of downtown Panama City; taxis and ride‑hailing services are common (fares generally in the mid-range for the region), while airport shuttles and private transfers offer fixed-price options. Tocumen provides extensive amenities and smooth connections for onward travel, but the distance from the city center and occasional peak‑hour congestion can add time and cost to transfers. For low‑cost or domestic services, Marcos A. Gelabert Airport (PAC) near the city serves regional and budget flights, offering very short transfers into the city (10–20 minutes) and a simpler, more budget‑oriented experience.
Mexico City — Panama City
03/31/2026
Departure
Direct flight
CM857
starting at $644
Mexico City — Panama City
04/04/2026
Departure
Direct flight
CM135
starting at $530
Mexico City — Panama City
04/17/2026
Departure
Direct flight
CM137
starting at $470
Mexico City — Panama City
04/20/2026
Departure
Direct flight
CM149
starting at $360
Mexico City — Panama City
01/14/2027
Departure
Direct flight
CM149
starting at $725
The Mexico City — Panama City route is served by multiple airlines, including Copa Airlines, Aeromexico, and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $147, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
The cheapest flight ticket from Mexico City to Panama City according to data for the last 48 hours costs $147
Often the best time to buy tickets from Mexico City to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Panama City can be found flying in these months: April, March.
The fastest flights from Mexico City to Panama City start from 3 hours 50 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Panama City: Copa Airlines
We couldn't find any special offers for flights from Mexico City to Panama City
The cheapest one-way flight from Mexico City to Panama City departs on 04/04/2026, is operated by Aeromexico and costs $147
The cheapest roundtrip flight from Mexico City to Panama City departs on 06/04/2026, is operated by Avianca and costs $420
Fastest flight from Mexico City to Panama City takes 3h 50m
There are direct flights on this route 5 days a week: Mo, Tu, Th, Fr, and Sa
The distance between Mexico City and Panama City is 2407km (1492 miles). There are 13 direct flights from Mexico City to Panama City. The time difference between Mexico City and Panama City is 1h. Flights from Mexico City begin at 5:55 AM. The latest flight from Mexico City departs at 2:00 AM