Cheap Flights from Mexico City to Panama City — $178

The route Mexico City — Panama City is served by many carriers — 4 in total, including Copa Airlines, Aeromexico, Avianca, and Volaris. This gives passengers wide opportunities: from finding the lowest fare (from $178) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.

Mexico City is primarily served by Benito Juárez International (MEX), the city’s main international hub that handles most full-service carriers and many low-cost airlines, and the newer Felipe Ángeles International (NLU), which mostly caters to budget and domestic flights. MEX sits close to the city center — about 15–20 km — with metro, airport shuttle buses, and taxis taking roughly 25–45 minutes depending on traffic; expect fares from modest metro prices up to mid-range taxi or ride-hail costs. NLU lies farther north (around 45–50 km), reachable by dedicated buses and longer taxi rides that typically take 50–90 minutes and can be cheaper on scheduled shuttles. Pros: MEX is convenient for business and international connections; NLU can offer lower fares and newer facilities. Cons: both can be affected by heavy traffic and peak-time congestion, and transfers between airports may add significant travel time.

The distance between Mexico City and Panama City is 2407km (1492 miles). The average flight duration is 4h. There are 55 direct flights from Mexico City to Panama City. The time difference between Mexico City and Panama City is 1h. Flights from Mexico City begin at 5:50 AM. The latest flight from Mexico City departs at 2:10 AM

Tocumen International (PTY) is Panama City’s primary international gateway and a major connecting hub for Latin America, typically serving full-service carriers like Copa Airlines alongside some international and regional carriers. Flights here can be priced competitively compared with secondary airports, though fares vary by route and season. The airport sits about 24–30 km (roughly 30–40 minutes without heavy traffic) east of downtown Panama City; taxis and ride‑hailing services are common (fares generally in the mid-range for the region), while airport shuttles and private transfers offer fixed-price options. Tocumen provides extensive amenities and smooth connections for onward travel, but the distance from the city center and occasional peak‑hour congestion can add time and cost to transfers. For low‑cost or domestic services, Marcos A. Gelabert Airport (PAC) near the city serves regional and budget flights, offering very short transfers into the city (10–20 minutes) and a simpler, more budget‑oriented experience.