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Fly from Mexico City to Panama City with confidence — our search scans over 700 airlines, 50+ agencies and more than 5 top booking systems to uncover the best prices, schedules and travel conditions for your trip. Compare nonstop and connecting options in seconds and book the ideal itinerary that fits your budget and timing.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Panama City:
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The route Mexico City — Panama City is served by many carriers — 5 in total, including Copa Airlines, Aeromexico, VivaAerobus, Volaris, and Avianca. This gives passengers wide opportunities: from finding the lowest fare (from $194) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
starting at $377
starting at $204
starting at $194
starting at $210
starting at $241
Mexico City — Panama City
02/06/2026
Departure
Direct flight
CM137
starting at $377
Mexico City — Panama City
02/14/2026
Departure
Direct flight
CM137
starting at $512
Mexico City — Panama City
02/24/2026
Departure
Direct flight
CM137
starting at $501
Mexico City — Panama City
02/25/2026
Departure
Direct flight
AM464
starting at $559
Mexico City — Panama City
02/27/2026
Departure
Direct flight
CM135
starting at $501
Mexico City — Panama City
02/28/2026
Departure
Direct flight
CM137
starting at $381
Mexico City — Panama City
03/02/2026
Departure
Direct flight
CM137
starting at $381
Mexico City — Panama City
03/03/2026
Departure
Direct flight
CM149
starting at $402
Mexico City — Panama City
06/20/2026
Departure
Direct flight
CM149
starting at $694
Copa Airlines
Every day
starting at $382
The cheapest one-way flight from Mexico City to Panama City departs on 02/06/2026, is operated by VivaAerobus and costs $194
The cheapest roundtrip flight from Mexico City to Panama City departs on 05/01/2026, is operated by Avianca and costs $346
Fastest flight from Mexico City to Panama City takes 8 hours
There are direct flights on this route 5 days a week: Mo, Tu, We, Fr, and Sa
The distance between Mexico City and Panama City is 2407km (1492 miles). There are 13 direct flights from Mexico City to Panama City. The time difference between Mexico City and Panama City is 1h. Flights from Mexico City begin at 5:55 AM. The latest flight from Mexico City departs at 2:00 AM
Mexico City is primarily served by Benito Juárez International (MEX), the city’s main international hub that handles most full-service carriers and many low-cost airlines, and the newer Felipe Ángeles International (NLU), which mostly caters to budget and domestic flights. MEX sits close to the city center — about 15–20 km — with metro, airport shuttle buses, and taxis taking roughly 25–45 minutes depending on traffic; expect fares from modest metro prices up to mid-range taxi or ride-hail costs. NLU lies farther north (around 45–50 km), reachable by dedicated buses and longer taxi rides that typically take 50–90 minutes and can be cheaper on scheduled shuttles. Pros: MEX is convenient for business and international connections; NLU can offer lower fares and newer facilities. Cons: both can be affected by heavy traffic and peak-time congestion, and transfers between airports may add significant travel time.
Fly direct from Mexico City to Panama City for the fastest, most convenient way to link the heart of Mexico with Panama’s vibrant capital — fewer hassles, no layovers, and more time to enjoy your trip. While connecting options can sometimes be cheaper, a nonstop flight saves hours and delivers greater comfort, making it the smart choice for business travelers and vacationers alike.
Tocumen International (PTY) is Panama City’s primary international gateway and a major connecting hub for Latin America, typically serving full-service carriers like Copa Airlines alongside some international and regional carriers. Flights here can be priced competitively compared with secondary airports, though fares vary by route and season. The airport sits about 24–30 km (roughly 30–40 minutes without heavy traffic) east of downtown Panama City; taxis and ride‑hailing services are common (fares generally in the mid-range for the region), while airport shuttles and private transfers offer fixed-price options. Tocumen provides extensive amenities and smooth connections for onward travel, but the distance from the city center and occasional peak‑hour congestion can add time and cost to transfers. For low‑cost or domestic services, Marcos A. Gelabert Airport (PAC) near the city serves regional and budget flights, offering very short transfers into the city (10–20 minutes) and a simpler, more budget‑oriented experience.
The cheapest flight ticket from Mexico City to Panama City according to data for the last 48 hours costs $194
Often the best time to buy tickets from Mexico City to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Panama City can be found flying in these months: February, March, May.
The fastest flights from Mexico City to Panama City start from 8 hours in the air.
The following airlines operate direct flights on the route Mexico City — Panama City: Copa Airlines, Aeromexico
In different months, ticket prices from Mexico City to Panama City vary: minimum — $210 (February 2026), maximum — $227 (June 2026). Typically, the flight costs $218–$225.
We couldn't find any special offers for flights from Mexico City to Panama City