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Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Santa Cruz. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
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Madrid — Santa Cruz
12/23/2026
Departure
Direct flight
UX025
starting at $1,083
Madrid — Santa Cruz
05/17/2026
Departure
Direct flight
OB777
starting at $435
Madrid — Santa Cruz
05/15/2026
Departure
Direct flight
OB777
starting at $439
Madrid — Santa Cruz
05/16/2026
Departure
Direct flight
UX25
starting at $608
Madrid — Santa Cruz
05/20/2026
Departure
Direct flight
UX25
starting at $578
Madrid — Santa Cruz
09/23/2026
Departure
Direct flight
UX025
starting at $588
Madrid — Santa Cruz
11/06/2026
Departure
Direct flight
OB777
starting at $480
starting at $578
starting at $435
starting at $384
starting at $722
The route Madrid — Santa Cruz is served by many carriers — 4 in total, including Air Europa, Boliviana de Aviación, Avianca, and Ryanair. This gives passengers wide opportunities: from finding the lowest fare (from $384) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
We couldn't find any special offers for flights from Madrid to Santa Cruz
The cheapest flight ticket from Madrid to Santa Cruz according to data for the last 48 hours costs $384
Often the best time to buy tickets from Madrid to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Santa Cruz can be found flying in these months: September, February, November.
The fastest flights from Madrid to Santa Cruz start from 10 hours in the air.
The following airlines operate direct flights on the route Madrid — Santa Cruz: Air Europa, Boliviana de Aviación
In different months, ticket prices from Madrid to Santa Cruz vary: minimum — $376 (September 2026), maximum — $693 (December 2026). Typically, the flight costs $511–$1,055.
The price trend from Madrid to Santa Cruz resembles a smile: costs drop, bottom out, then recover. Knowing this, you can pick dates with the best prices.
Prices fall from June 2026 to September 2026 (32%), then rise from September 2026 to December 2026 (+84%). The best period is September 2026–November 2026 ($438), the most expensive is November 2026–December 2026 ($597).
The best time to buy is September 2026–November 2026, when prices are at their lowest. This can save you up to 27% compared to the expensive months (November 2026–December 2026).
Monthly price variation is 21.5%. On this route, your departure date noticeably affects the cost, and choosing wisely can lead to real savings.
The cheapest one-way flight from Madrid to Santa Cruz departs on 05/20/2026, is operated by Avianca and costs $384
The cheapest roundtrip flight from Madrid to Santa Cruz departs on 05/14/2026, is operated by Avianca and costs $1,239
Fastest flight from Madrid to Santa Cruz takes 10 hours
There are direct flights on this route 4 days a week: Su, We, Fr, and Sa
The distance between Madrid and Santa Cruz is 8919km (5530 miles). There are 2 direct flights from Madrid to Santa Cruz. The time difference between Madrid and Santa Cruz is 5h. Flights from Madrid begin at 9:00 PM. The latest flight from Madrid departs at 9:00 PM
