starting at $684
starting at $516
starting at $459
starting at $364
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Santa Cruz. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The route Madrid — Santa Cruz is served by many carriers — 4 in total, including Iberia, Boliviana de Aviación, Air Europa, and Avianca. This gives passengers wide opportunities: from finding the lowest fare (from $364) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
starting at $684
starting at $516
starting at $459
starting at $364
Madrid — Santa Cruz
08/12/2026
Departure
Direct flight
IB7790
starting at $811
Madrid — Santa Cruz
08/14/2026
Departure
Direct flight
OB777
starting at $747
Madrid — Santa Cruz
08/16/2026
Departure
Direct flight
IB7790
starting at $684
Madrid — Santa Cruz
09/05/2026
Departure
Direct flight
UX025
starting at $581
Madrid — Santa Cruz
09/23/2026
Departure
Direct flight
OB777
starting at $598
Madrid — Santa Cruz
09/30/2026
Departure
Direct flight
UX25
starting at $570
Madrid — Santa Cruz
01/10/2027
Departure
Direct flight
OB777
starting at $524
Madrid — Santa Cruz
02/01/2027
Departure
Direct flight
OB777
starting at $595
There are most likely no direct flights on the Madrid — Santa Cruz route
The cheapest one-way flight from Madrid to Santa Cruz departs on 09/08/2026, is operated by Avianca and costs $364
The cheapest roundtrip flight from Madrid to Santa Cruz departs on 07/01/2027, is operated by Avianca and costs $1,105
Fastest flight from Madrid to Santa Cruz takes 10 hours
There are direct flights on this route 5 days a week: Su, Mo, We, Fr, and Sa
The distance between Madrid and Santa Cruz is 8919km (5530 miles). There are 2 direct flights from Madrid to Santa Cruz. The time difference between Madrid and Santa Cruz is 5h. Flights from Madrid begin at 9:00 PM. The latest flight from Madrid departs at 9:00 PM
The cheapest flight ticket from Madrid to Santa Cruz according to data for the last 48 hours costs $364
Often the best time to buy tickets from Madrid to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Santa Cruz can be found flying in these months: September, February, January.
The fastest flights from Madrid to Santa Cruz start from 10 hours in the air.
The following airlines operate direct flights on the route Madrid — Santa Cruz: Iberia, Boliviana de Aviación, Air Europa
In different months, ticket prices from Madrid to Santa Cruz vary: minimum — $374 (September 2026), maximum — $529 (October 2026). Typically, the flight costs $439–$878.
Flight costs on the Madrid — Santa Cruz route are confidently going down. From August 2026 to February 2027, prices fell from $459 to $414 — a 10% decrease. A welcome trend for travelers.
The most notable drop occurred from October 2026 to February 2027 — down 22%. The best period is August 2026–September 2026 (averaging $416), while the most expensive is October 2026–January 2027 ($474).
Since prices are falling, there's no rush to buy. The most cost-effective travel period is August 2026–September 2026: savings compared to expensive months can reach up to 12%.
Monthly price variation is 11.9%. Choosing the right departure date can lead to significant savings on this route.
