Unable to find information about the schedule of direct flights from
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Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Santa Cruz. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Madrid to Santa Cruz:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Unable to find information about the schedule of direct flights from
The cheapest one-way flight from Madrid to Santa Cruz departs on 04/24/2026, is operated by Avianca and costs $425
The cheapest roundtrip flight from Madrid to Santa Cruz departs on 05/15/2026, is operated by Avianca and costs $858
Fastest flight from Madrid to Santa Cruz takes 18h 40m
There are no direct flights on this route.
The distance between Madrid and Santa Cruz is 8919km (5530 miles). There are 10 direct flights from Madrid to Santa Cruz. The time difference between Madrid and Santa Cruz is 5h. Flights from Madrid begin at 1:45 PM. The latest flight from Madrid departs at 3:05 AM
In different months, ticket prices from Madrid to Santa Cruz vary: minimum — $418 (May 2026), maximum — $514 (December 2025). Typically, the flight costs $487–$508.
Madrid — Santa Cruz
12/27/2025
Departure
Direct flight
UX25
starting at $1,197
Madrid — Santa Cruz
04/24/2026
Departure
Direct flight
OB777
starting at $500
Madrid — Santa Cruz
04/25/2026
Departure
Direct flight
UX25
starting at $598
Madrid — Santa Cruz
04/26/2026
Departure
Direct flight
OB777
starting at $500
Madrid — Santa Cruz
04/27/2026
Departure
Direct flight
UX25
starting at $597
Madrid — Santa Cruz
05/11/2026
Departure
Direct flight
UX25
starting at $598
starting at $597
starting at $500
starting at $425
starting at $948
The route Madrid — Santa Cruz is served by many carriers — 4 in total, including Air Europa, Boliviana de Aviación, Avianca, and Azul Brazilian Airlines. This gives passengers wide opportunities: from finding the lowest fare (from $425) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
The cheapest flight ticket from Madrid to Santa Cruz according to data for the last 48 hours costs $425
Often the best time to buy tickets from Madrid to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Santa Cruz can be found flying in these months: May, February, April.
The fastest flights from Madrid to Santa Cruz start from 18 hours 40 minutes in the air.
The following airlines operate direct flights on the route Madrid — Santa Cruz: Air Europa, Boliviana de Aviación
We couldn't find any special offers for flights from Madrid to Santa Cruz
