Schedule of direct flights from Madrid to Santa Cruz
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Madrid to Santa Cruz:
Madrid airports overview
Santa Cruz airports overview
Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Madrid to Santa Cruz
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
•••••••••••••••••••
Cheapest one way flight
$438
LATAM Chile
1 transfer
1d 9h
03/21/2025
The cheapest one-way flight from Madrid to Santa Cruz departs on 03/21/2025, is operated by LATAM Chile and costs $438
Cheapest round trip flight
$831
LATAM Chile
1 transfer
2d 14h 55m
12/06/2025
The cheapest roundtrip flight from Madrid to Santa Cruz departs on 12/06/2025, is operated by LATAM Chile and costs $831
The fastest flight
11 hours
Fastest flight from Madrid to Santa Cruz takes 11 hours
Direct flights
Several times a week
There are direct flights on this route 2 days a week: Su and We
Earliest flight
1:45 PM
Latest flight
11:35 PM
Direct flights count
9
Distance
8919km
Timezone difference
5h
The distance between Madrid and Santa Cruz is 8919km (5530 miles).There are 9 direct flights from Madrid to Santa Cruz.The time difference between Madrid and Santa Cruz is 5h .Flights from Madrid begin at 1:45 PM.The latest flight from Madrid departs at 11:35 PM.
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Santa Cruz. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
Unable to find information about the schedule of direct flights from
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Madrid to Santa Cruz
How much is the cheapest flight ticket from Madrid to Santa Cruz?
The cheapest flight ticket from Madrid to Santa Cruz according to data for the last 48 hours costs $438
When is the best time to buy air tickets on the route Madrid — Santa Cruz?
Often the best time to buy tickets from Madrid to Santa Cruz is 2 months before departure.
When is the cheapest time of year to fly from Madrid to Santa Cruz?
Based on statistics over the past years, the lowest prices for flights from Madrid to Santa Cruz can be found flying in these months: March.
How long does it take to fly from Madrid to Santa Cruz?
The fastest flights from Madrid to Santa Cruz start from 11 hours in the air.
Which airline can fly direct from Madrid to Santa Cruz?
The following airlines operate direct flights on the route Madrid — Santa Cruz: Air Europa, Boliviana de Aviación
Below you will find a list of airlines operating flights on the Madrid — Santa Cruz route and the starting prices for flights of each specific airline on it.
A direct flight is the most convenient and comfortable way to fly from Madrid to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
