There are most likely no direct flights on the Madrid — Santa Cruz route
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Santa Cruz. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
In different months, ticket prices from Madrid to Santa Cruz vary: minimum — $390 (May 2027), maximum — $660 (December 2026). Typically, the flight costs $511–$1,113.
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Flight costs on the Madrid — Santa Cruz route are confidently going down. From November 2026 to May 2027, prices fell from $570 to $390 — a 32% decrease. A welcome trend for travelers.
The most notable drop occurred from December 2026 to May 2027 — down 41%. The best period is February 2027–May 2027 (averaging $392), while the most expensive is November 2026–December 2026 ($615).
Since prices are falling, there's no rush to buy. The most cost-effective travel period is February 2027–May 2027: savings compared to expensive months can reach up to 36%.
Monthly price variation is 20.5%. Choosing the right departure date can lead to significant savings on this route.
There are most likely no direct flights on the Madrid — Santa Cruz route
All airports
We couldn't find any special offers for flights from Madrid to Santa Cruz
Madrid — Santa Cruz
11/20/2026
Departure
Direct flight
OB777
starting at $1,155
Madrid — Santa Cruz
12/12/2026
Departure
Direct flight
UX025
starting at $1,478
Madrid — Santa Cruz
01/18/2027
Departure
Direct flight
UX25
starting at $559
Madrid — Santa Cruz
12/27/2026
Departure
Direct flight
UX25
starting at $788
Madrid — Santa Cruz
11/18/2026
Departure
Direct flight
OB7790
starting at $1,076
Madrid — Santa Cruz
11/27/2026
Departure
Direct flight
OB777
starting at $1,156
Madrid — Santa Cruz
12/04/2026
Departure
Direct flight
OB7790
starting at $1,240
Madrid — Santa Cruz
11/17/2026
Departure
Direct flight
OB7790
starting at $1,275
Madrid — Santa Cruz
05/26/2027
Departure
Direct flight
OB777
starting at $406
starting at $406
starting at $559
starting at $393
starting at $650
starting at $749
starting at $779
The route Madrid — Santa Cruz is served by many carriers — 6 in total, including Boliviana de Aviación, Air Europa, Avianca, Azul Brazilian Airlines, ITA Airways, and Iberia. This gives passengers wide opportunities: from finding the lowest fare (from $393) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
The cheapest flight ticket from Madrid to Santa Cruz according to data for the last 48 hours costs $393
Often the best time to buy tickets from Madrid to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Santa Cruz can be found flying in these months: May, February, January.
The fastest flights from Madrid to Santa Cruz start from 11 hours 20 minutes in the air.
The following airlines operate direct flights on the route Madrid — Santa Cruz: Boliviana de Aviación, Air Europa
The cheapest one-way flight from Madrid to Santa Cruz departs on 05/25/2027, is operated by Avianca and costs $393
The cheapest roundtrip flight from Madrid to Santa Cruz departs on 03/24/2027, is operated by Avianca and costs $601
Fastest flight from Madrid to Santa Cruz takes 11h 20m
There are direct flights on this route 6 days a week: Su, Mo, Tu, We, Fr, and Sa
The distance between Madrid and Santa Cruz is 8918km (5529 miles). There are 14 direct flights from Madrid to Santa Cruz. The time difference between Madrid and Santa Cruz is 5h. Flights from Madrid begin at 2:45 PM. The latest flight from Madrid departs at 3:05 AM
