Cheap Flights from Knoxville to Chicago Starting at $45

Helping travelers to find the best flight offers

Cheapest flights from Knoxville to Chicago

Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Knoxville to Chicago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.

Cheapest one way flight

$45

Allegiant Air
Allegiant Air
Direct flight
1h 33m
07/21/2025

The cheapest one-way flight from Knoxville to Chicago departs on 07/21/2025, is operated by Allegiant Air and costs $45

Cheapest round trip flight

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There is no information about the cheapest roundtrip flight from Knoxville to Chicago

The fastest flight

1h 33m

Fastest flight from Knoxville to Chicago takes 1h 33m

Direct flights

Several times a week

There are direct flights on this route 2 days a week: Mo and Fr

Earliest flight

7:00 AM

Latest flight

6:39 PM

Direct flights count

64

Distance

744km

Timezone difference

1h

The distance between Knoxville and Chicago is 744km (461 miles). There are 64 direct flights from Knoxville to Chicago. The time difference between Knoxville and Chicago is 1h . Flights from Knoxville begin at 7:00 AM. The latest flight from Knoxville departs at 6:39 PM.

See also:

Cheap flights to United States

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Direct flights airfares to Chicago

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Cheapest air tickets to Knoxville

Airfare from Knoxville to Chicago by month

We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Knoxville to Chicago

Airlines operating on route

Below you will find a list of airlines operating flights on the Knoxville — Chicago route and the starting prices for flights of each specific airline on it.

Allegiant Air
Allegiant Air

Starting at $60

American Airlines
American Airlines

Starting at $99

Direct Flights from Knoxville to Chicago

A direct flight is the most convenient and comfortable way to fly from Knoxville to Chicago, despite the fact that sometimes flights with transfers can cost significantly less.

Chicago city image

Knoxville — Chicago

TYS — CHI

07/23/2025

Departure date

Direct flight

Republic Airlines

YX4536

Starting at $199

Chicago city image

Knoxville — Chicago

TYS — CHI

07/24/2025

Departure date

Direct flight

Republic Airlines

YX4536

Starting at $281

Schedule of direct flights from Knoxville to Chicago

A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Knoxville to Chicago:

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Unable to find information about the schedule of direct flights from

Knoxville airports overview

TYS
McGhee Tyson Airport
United Airlines
American Airlines
Airlines flying to this airport
$99
Starting at
$274
on average

Chicago airports overview

ORD
O'Hare International Airport
United Airlines
American Airlines
Airlines flying to this airport
$99
Starting at
$274
on average

Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

Special offers and sales on air tickets from Knoxville to Chicago

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

Alternative routes

Atlanta ➜ Chicago•Asheville ➜ Chicago•Birmingham ➜ Chicago•Nashville ➜ Chicago•Chattanooga ➜ Chicago•Charlotte ➜ Chicago•Charleston ➜ Chicago•Winston-Salem ➜ Chicago•Knoxville ➜ Appleton•Knoxville ➜ Kalamazoo•Knoxville ➜ Champaign•Knoxville ➜ Fort Wayne•Knoxville ➜ Indianapolis•Knoxville ➜ Lansing•Knoxville ➜ Milwaukee•Knoxville ➜ Muskegon•Knoxville ➜ South Bend