There are most likely no direct flights on the Knoxville — Chicago route
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A non-stop flight is the most convenient and comfortable way to fly from Knoxville to Chicago, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Knoxville — Chicago route
Knoxville — Chicago
09/13/2026
Departure
Direct flight
AA3716
starting at $315
Knoxville — Chicago
11/27/2026
Departure
Direct flight
UA5478
starting at $292
Knoxville — Chicago
01/18/2027
Departure
Direct flight
UA4519
starting at $441
Knoxville — Chicago
09/07/2026
Departure
Direct flight
AA4970
starting at $338
starting at $315
starting at $292
starting at $161
starting at $161
starting at $278
More than 5 airlines operate flights from Knoxville to Chicago, including American Airlines, United Airlines, Southwest Airlines, TEM Enterprises, and Allegiant Air. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $161, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
The cheapest one-way flight from Knoxville to Chicago departs on 01/18/2027, is operated by Southwest Airlines and costs $161
The cheapest roundtrip flight from Knoxville to Chicago departs on 09/08/2026, is operated by Southwest Airlines and costs $387
Fastest flight from Knoxville to Chicago takes 5h 40m
There are direct flights on this route 3 days a week: Su, Mo, and Fr
The distance between Knoxville and Chicago is 731km (453 miles). There are 64 direct flights from Knoxville to Chicago. The time difference between Knoxville and Chicago is 1h. Flights from Knoxville begin at 7:00 AM. The latest flight from Knoxville departs at 7:18 PM
We couldn't find any special offers for flights from Knoxville to Chicago
The cheapest flight ticket from Knoxville to Chicago according to data for the last 48 hours costs $161
Often the best time to buy tickets from Knoxville to Chicago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Knoxville to Chicago can be found flying in these months: January, September, November.
The fastest flights from Knoxville to Chicago start from 5 hours 40 minutes in the air.
The following airlines operate direct flights on the route Knoxville — Chicago: American Airlines, United Airlines
The cost of a one-way flight from Knoxville to Chicago ranges from $161 (January 2027) to $193 (November 2026). On average, the ticket price is about $172–$354.
Tickets from Knoxville to Chicago cost roughly the same any month. This is convenient: you can plan your trip based on your schedule rather than prices.
There is a slight difference: it's a bit cheaper in November 2026–January 2027 (averaging $177) and slightly more in September 2026–November 2026 ($177). But overall, the difference is small.
On this route, you don't need to target specific months — prices are stable. The difference between the cheapest and most expensive period is only 0%. Book whenever it's convenient.
Monthly price variation is just 8.9%. Ticket costs on this route are among the most predictable.
