LATAM Chile
Su, Mo, Tu, and Sa
starting at $173
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Cuzco to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Cuzco to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
The only airline operating direct flights from Cuzco to Santiago is LATAM Chile. Flights operate on Sunday, Monday, Tuesday, and Saturday.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
LATAM Chile
Su, Mo, Tu, and Sa
starting at $173
The cost of a one-way flight from Cuzco to Santiago ranges from $146 (May 2026) to $215 (June 2026). On average, the ticket price is about $185–$381.
Tickets from Cuzco to Santiago are getting cheaper month by month. From May 2026 to March 2027, the decline reached 23% — and that may not be the limit.
The most notable drop occurred from June 2026 to March 2027 — down 16%. The best period is February 2027–March 2027 (averaging $180), while the most expensive is June 2026–January 2027 ($208).
Since prices are falling, there's no rush to buy. The most cost-effective travel period is February 2027–March 2027: savings compared to expensive months can reach up to 13%.
Monthly price variation is 12.5%. Choosing the right departure date can lead to significant savings on this route.
Cuzco — Santiago
06/10/2026
Departure
Direct flight
LA2366
starting at $307
Cuzco — Santiago
07/21/2026
Departure
Direct flight
LA2366
starting at $486
Cuzco — Santiago
10/07/2026
Departure
Direct flight
LA2366
starting at $413
Cuzco — Santiago
10/20/2026
Departure
Direct flight
LA2366
starting at $217
Cuzco — Santiago
10/23/2026
Departure
Direct flight
LA2366
starting at $300
Cuzco — Santiago
05/15/2026
Departure
Direct flight
LA2466
starting at $123
starting at $123
starting at $132
starting at $165
starting at $189
More than 4 airlines operate flights from Cuzco to Santiago, including LATAM Chile, Jatayu Airlines, B&H Airlines, and Sky Airline. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $123, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
The cheapest flight ticket from Cuzco to Santiago according to data for the last 48 hours costs $123
Often the best time to buy tickets from Cuzco to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Cuzco to Santiago can be found flying in these months: May, February, March.
The fastest flights from Cuzco to Santiago start from 3 hours 20 minutes in the air.
The following airlines operate direct flights on the route Cuzco — Santiago: LATAM Chile
The cheapest one-way flight from Cuzco to Santiago departs on 05/15/2026, is operated by LATAM Chile and costs $123
There is no information about the cheapest roundtrip flight from Cuzco to Santiago
Fastest flight from Cuzco to Santiago takes 3h 20m
There are direct flights on this route 3 days a week: Tu, We, and Fr
The distance between Cuzco and Santiago is 2214km (1373 miles). The average flight duration is 3h 20m. There are 3 direct flights from Cuzco to Santiago. The time difference between Cuzco and Santiago is 1h. Flights from Cuzco begin at 9:30 AM. The latest flight from Cuzco departs at 2:40 PM
We couldn't find any special offers for flights from Cuzco to Santiago
