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Fly from Antofagasta to Santiago with confidence—our search scans over 700 airlines, 50+ travel agencies and more than 5 top booking systems to surface the best fares, schedules and ticket conditions for your trip. Quick, clear comparisons help you pick the ideal flight so you can relax knowing you got the best deal and timing for your journey to Chile’s capital.
Fly direct from Antofagasta to Santiago for the quickest, most convenient way to get between Chile’s north and capital — fewer hassles and more time for what matters. While connecting routes can sometimes be cheaper, a non-stop flight saves hours and offers a more comfortable, stress-free journey; book now to lock in convenience.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Antofagasta to Santiago:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The cheapest one-way flight from Antofagasta to Santiago departs on 01/11/2026, is operated by Sky Airline and costs $40
There is no information about the cheapest roundtrip flight from Antofagasta to Santiago
Fastest flight from Antofagasta to Santiago takes 1h 52m
There are direct flights on this route 4 days a week: Su, Mo, Th, and Fr
The distance between Antofagasta and Santiago is 1108km (687 miles). There are 143 direct flights from Antofagasta to Santiago. Antofagasta and Santiago are in the same time zone. Flights from Antofagasta begin at 6:46 AM. The latest flight from Antofagasta departs at 2:13 AM
Flights from Antofagasta to Santiago are operated by several airlines — B&H Airlines and Sky Airline. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $40, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.
Starting at $44
Starting at $40
Antofagasta — Santiago
10/20/2025
Departure
Direct flight
JA57
Starting at $48
Antofagasta — Santiago
10/22/2025
Departure
Direct flight
JA53
Starting at $152
Antofagasta — Santiago
12/26/2025
Departure
Direct flight
JA63
Starting at $50
Antofagasta — Santiago
01/11/2026
Departure
Direct flight
H2289
Starting at $40
Sky Airline
Every day
Starting at $21
Comodoro Arturo Merino Benítez (Andrés Sabella) — Antofagasta's main airport is a medium-sized regional gateway handling domestic flights and a few international connections, often serving full-service carriers and local budget airlines alike. Located about 10–15 km north of the city center, it can be reached in roughly 15–30 minutes by taxi or shuttle; buses and ride-hailing services are also available with fares typically lower than private transfers. Travelers can expect a straightforward, functional terminal with basic amenities—convenient for quick connections but not as large as major international hubs. Pros: close to town and efficient for domestic travel; cons: limited long-haul options and fewer lounge or dining choices compared with larger airports.
Santiago’s main air gateway is Comodoro Arturo Merino Benítez International Airport (SCL), the country’s primary international hub handling most long-haul and regional flights and serving carriers like LATAM, Sky Airline and JetSMART. It sits about 16 km northwest of downtown Santiago, with travel times typically around 20–40 minutes by taxi or ride-hail depending on traffic, and roughly 30–45 minutes by the airport express bus (fare ranges commonly fall in the low-to-mid single-digit USD equivalent). SCL offers a full range of passenger services and lounges but can be busy at peak times; public transport is affordable but may feel less convenient for luggage. For budget travellers, some low-cost carriers operate out of secondary terminals within the same complex, which can mean simpler facilities and sometimes lower fares.
The cheapest flight ticket from Antofagasta to Santiago according to data for the last 48 hours costs $40
Often the best time to buy tickets from Antofagasta to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Antofagasta to Santiago can be found flying in these months: November, October.
The fastest flights from Antofagasta to Santiago start from 1 hour 52 minutes in the air.
The following airlines operate direct flights on the route Antofagasta — Santiago: B&H Airlines, Sky Airline
The cost of a one-way flight from Antofagasta to Santiago ranges from $41 (November 2025) to $42 (October 2025). On average, the ticket price is about $42–$42.
We couldn't find any special offers for flights from Antofagasta to Santiago