There are most likely no direct flights on the Antofagasta — Santiago route
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A non-stop flight is the most convenient and comfortable way to fly from Antofagasta to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
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There are most likely no direct flights on the Antofagasta — Santiago route
Antofagasta — Santiago
09/23/2026
Departure
Direct flight
LA137
starting at $60
Antofagasta — Santiago
09/14/2026
Departure
Direct flight
JA067
starting at $79
Antofagasta — Santiago
09/09/2026
Departure
Direct flight
LA131
starting at $177
Antofagasta — Santiago
10/29/2026
Departure
Direct flight
LA359
starting at $223
Antofagasta — Santiago
10/30/2026
Departure
Direct flight
LA349
starting at $74
Flights from Antofagasta to Santiago are operated by several airlines — LATAM Chile, B&H Airlines, and Sky Airline. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $43, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.
The cheapest flight ticket from Antofagasta to Santiago according to data for the last 48 hours costs $43
Often the best time to buy tickets from Antofagasta to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Antofagasta to Santiago can be found flying in these months: November, September, October.
The fastest flights from Antofagasta to Santiago start from 1 hour 53 minutes in the air.
The following airlines operate direct flights on the route Antofagasta — Santiago: LATAM Chile, B&H Airlines
The cost of a one-way flight from Antofagasta to Santiago ranges from $30 (November 2026) to $45 (October 2026). On average, the ticket price is about $39–$88.
Ticket prices for Antofagasta — Santiago are higher at the start and end of the period but lowest in the middle. This creates a convenient window for booking at a reduced price.
Prices fall from October 2026 to November 2026 (32%), then rise from September 2026 to October 2026 (+4%). The best period is October 2026–November 2026 ($38), the most expensive is September 2026–October 2026 ($44).
The best time to buy is October 2026–November 2026, when prices are at their lowest. This can save you up to 14% compared to the expensive months (September 2026–October 2026).
Monthly price variation is 16.1%. On this route, your departure date noticeably affects the cost, and choosing wisely can lead to real savings.
We couldn't find any special offers for flights from Antofagasta to Santiago
Comodoro Arturo Merino Benítez (Andrés Sabella) — Antofagasta's main airport is a medium-sized regional gateway handling domestic flights and a few international connections, often serving full-service carriers and local budget airlines alike. Located about 10–15 km north of the city center, it can be reached in roughly 15–30 minutes by taxi or shuttle; buses and ride-hailing services are also available with fares typically lower than private transfers. Travelers can expect a straightforward, functional terminal with basic amenities—convenient for quick connections but not as large as major international hubs. Pros: close to town and efficient for domestic travel; cons: limited long-haul options and fewer lounge or dining choices compared with larger airports.
Santiago’s main air gateway is Comodoro Arturo Merino Benítez International Airport (SCL), the country’s primary international hub handling most long-haul and regional flights and serving carriers like LATAM, Sky Airline and JetSMART. It sits about 16 km northwest of downtown Santiago, with travel times typically around 20–40 minutes by taxi or ride-hail depending on traffic, and roughly 30–45 minutes by the airport express bus (fare ranges commonly fall in the low-to-mid single-digit USD equivalent). SCL offers a full range of passenger services and lounges but can be busy at peak times; public transport is affordable but may feel less convenient for luggage. For budget travellers, some low-cost carriers operate out of secondary terminals within the same complex, which can mean simpler facilities and sometimes lower fares.
The cheapest one-way flight from Antofagasta to Santiago departs on 10/29/2026, is operated by B&H Airlines and costs $43
There is no information about the cheapest roundtrip flight from Antofagasta to Santiago
Fastest flight from Antofagasta to Santiago takes 1h 53m
There are direct flights on this route 4 days a week: Mo, We, Th, and Fr
The distance between Antofagasta and Santiago is 1089km (675 miles). The average flight duration is 1h 57m. There are 145 direct flights from Antofagasta to Santiago. Antofagasta and Santiago are in the same time zone. Flights from Antofagasta begin at 7:12 AM. The latest flight from Antofagasta departs at 2:00 AM
