There are most likely no direct flights on the La Serena — Santiago route
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A non-stop flight is the most convenient and comfortable way to fly from La Serena to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
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There are most likely no direct flights on the La Serena — Santiago route
La Serena — Santiago
11/12/2026
Departure
Direct flight
H21717
starting at $27
La Serena — Santiago
11/14/2026
Departure
Direct flight
JA613
starting at $34
starting at $27
starting at $34
Flights from La Serena to Santiago are operated by several airlines — Sky Airline and B&H Airlines. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $27, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.
The cheapest one-way flight from La Serena to Santiago departs on 11/12/2026, is operated by Sky Airline and costs $27
There is no information about the cheapest roundtrip flight from La Serena to Santiago
Fastest flight from La Serena to Santiago takes 1h 1m
There are direct flights on this route 2 days a week: Th and Sa
The distance between La Serena and Santiago is 398km (247 miles). There are 69 direct flights from La Serena to Santiago. La Serena and Santiago are in the same time zone. Flights from La Serena begin at 7:51 AM. The latest flight from La Serena departs at 11:33 PM
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from La Serena to Santiago
The cheapest flight ticket from La Serena to Santiago according to data for the last 48 hours costs $27
Often the best time to buy tickets from La Serena to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from La Serena to Santiago can be found flying in these months: November.
The fastest flights from La Serena to Santiago start from 1 hour 1 minute in the air.
The following airlines operate direct flights on the route La Serena — Santiago: Sky Airline, B&H Airlines
We couldn't find any special offers for flights from La Serena to Santiago