Helping travelers to find the best flight offers
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mendoza to Santiago:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Looking for budget-friendly flights from Mendoza, Argentina to Santiago, Chile? Look no further! Our air ticket search website offers great deals on flight bookings, ensuring you get the best value for your money. Explore the vibrant cities of Mendoza and Santiago without worrying about hefty airfare expenses. Discover the enchanting landscapes of Mendoza, nestled in the heart of Argentina's wine country. Whether it's wine tasting, hiking through the picturesque Andes, or indulging in mouthwatering Argentine cuisine, Mendoza has something for everyone. Hop on a short flight to Santiago, Chile, and uncover the charm of this cosmopolitan capital. Dive into Chilean culture, stroll through colorful neighborhoods, and visit the iconic La Moneda Palace. And don't forget to relish the delicious local cuisine and explore the nearby breathtaking valleys and mountains. What are you waiting for? Find the cheapest flights from Mendoza to Santiago on our website and embark on an unforgettable journey.
The route Mendoza — Santiago is served by several airlines: Sky Airline and LATAM Chile. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $49 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
Starting at $49
Starting at $79
Looking for direct flights from Mendoza, Argentina to Santiago, Chile? Look no further! Currently, there are no direct flights on this route. However, fret not, as there are several convenient alternative routes available with transfers. One popular option is taking a connecting flight via Buenos Aires, Argentina. Several airlines operate flights from Mendoza to Buenos Aires, where you can catch a connecting flight to Santiago. Another possible route is via Córdoba, Argentina, where you can take a connecting flight to Santiago. These alternative routes provide flexibility and convenience for your travel plans. To find the best deals and compare prices, use our air ticket search website. Start planning your trip to Santiago today and explore all the beauty and culture this vibrant city has to offer!
Mendoza — Santiago
10/18/2025
Departure
Direct flight
H2526
Starting at $49
Mendoza — Santiago
03/22/2026
Departure
Direct flight
H2528
Starting at $58
Mendoza — Santiago
01/19/2026
Departure
Direct flight
H2526
Starting at $58
Mendoza — Santiago
01/13/2026
Departure
Direct flight
H2528
Starting at $58
Mendoza — Santiago
10/30/2025
Departure
Direct flight
H2526
Starting at $61
Mendoza — Santiago
12/02/2025
Departure
Direct flight
H2524
Starting at $62
Mendoza — Santiago
01/18/2026
Departure
Direct flight
LA435
Starting at $79
Mendoza — Santiago
10/29/2025
Departure
Direct flight
H2526
Starting at $89
Mendoza — Santiago
12/28/2025
Departure
Direct flight
H2526
Starting at $102
Mendoza — Santiago
01/04/2026
Departure
Direct flight
LA435
Starting at $133
Sky Airline
Every day
Starting at $75
LATAM Chile
Every day
Starting at $76
Looking to explore the vibrant city of Santiago, Chile? Discover the convenience of its airports! Santiago boasts two major airports, Comodoro Arturo Merino Benitez International Airport and La Florida Airport. Comodoro Arturo Merino Benitez International Airport is the main gateway to Santiago, preferred by a multitude of prestigious airlines as their hub. Connecting travelers to major international destinations, this airport guarantees a wide range of options for long-haul flights. With its modern facilities and top-notch amenities, passengers can enjoy a comfortable and efficient travel experience. Although transportation to the city center may take longer due to traffic, the airport offers various transport options including buses, taxis, and ride-sharing services. On the other hand, La Florida Airport, located near the city center, offers a convenient alternative for domestic flights with a smaller number of airlines operating from this airport. Travelers arriving here benefit from shorter travel times to downtown Santiago, thus saving both time and money. While it may have fewer international connections, La Florida Airport ensures hassle-free arrivals, making it an excellent choice for those with Santiago as their final destination. Whether you arrive at Comodoro Arturo Merino Benitez International Airport or La Florida Airport, Santiago's diverse culture and breathtaking sights await you. Discover the wonders of this South American metropolis, from its stunning landscapes to its rich history, and create unforgettable memories. Book your air tickets now to embark on an incredible journey through Santiago, Chile!
Welcome to Mendoza, Argentina's stunning wine country! When it comes to flying out, you have two airports to choose from. Let's dive into the details of each: First up is El Plumerillo International Airport (MDZ). Located just 10 kilometers from downtown Mendoza, this airport offers convenience in terms of travel time and cost. You can reach it within a 15-minute drive, making it a perfect choice for those looking to save time and avoid long commutes. MDZ serves as a hub for reputable airlines like Aerolíneas Argentinas and Latam Airlines, offering a wide range of domestic and international flights. On the downside, El Plumerillo International Airport is relatively small compared to other major airports. This means that it may have limited amenities and dining options. However, its size ensures easy navigation, shorter queues, and faster check-ins, making your departure experience hassle-free. Alternatively, you can consider San Rafael Airport (AFA), located around 230 kilometers south of Mendoza city. While the distance might deter some travelers, San Rafael Airport compensates with scenic drives through picturesque landscapes. Although smaller in size, this airport is known for its tranquility and efficient service, ensuring a smooth departure process. Keep in mind that San Rafael Airport serves a smaller number of airlines, mainly operating domestic flights. However, this can be an advantage for those seeking a quieter travel experience away from the crowd. In conclusion, both El Plumerillo International Airport and San Rafael Airport offer their own set of benefits. If you value convenience, shorter travel time, and a wide variety of flight options, MDZ is your best bet. On the other hand, if you prefer a serene departure experience, don't mind a longer drive, and are looking for domestic connections, AFA might be the perfect choice for you. Fly hassle-free from Mendoza, whether you're exploring nearby destinations or embarking on an unforgettable international journey. Book your tickets now and let the adventure begin!
We couldn't find any special offers for flights from Mendoza to Santiago
The cheapest one-way flight from Mendoza to Santiago departs on 10/18/2025, is operated by Sky Airline and costs $49
The cheapest roundtrip flight from Mendoza to Santiago departs on 10/16/2025, is operated by Sky Airline and costs $74
Fastest flight from Mendoza to Santiago takes 0h 56m
There are direct flights on this route 6 days a week: Su, Mo, Tu, We, Th, and Sa
The distance between Mendoza and Santiago is 175km (109 miles). The average flight duration is 58m. There are 28 direct flights from Mendoza to Santiago. The time difference between Mendoza and Santiago is 1h. Flights from Mendoza begin at 11:20 AM. The latest flight from Mendoza departs at 9:00 PM
The cheapest flight ticket from Mendoza to Santiago according to data for the last 48 hours costs $49
Often the best time to buy tickets from Mendoza to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mendoza to Santiago can be found flying in these months: January, November, October.
The fastest flights from Mendoza to Santiago start from 56 minutes in the air.
The following airlines operate direct flights on the route Mendoza — Santiago: Sky Airline, LATAM Chile
The minimum one-way ticket price from Mendoza to Santiago is $74 (January 2026), while the maximum is $87 (October 2025). On average, a ticket costs $79–$164.