starting at $346
starting at $369
Compare airlines, prices, and flight durations for your trip
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santo Domingo to Sao Paulo. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Santo Domingo to Sao Paulo, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santo Domingo to Sao Paulo:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The Santo Domingo — Sao Paulo route is served by multiple airlines, including Avianca and Frontier Airlines. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $346, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
starting at $346
starting at $369
There appear to be no non-stop flights from Santo Domingo to Sao Paulo at this time.... Well, or something went wrong on our side and we couldn't find anything
Unable to find information about the schedule of direct flights from
The cheapest one-way flight from Santo Domingo to Sao Paulo departs on 02/27/2026, is operated by Avianca and costs $346
The cheapest roundtrip flight from Santo Domingo to Sao Paulo departs on 05/20/2026, is operated by Asian Air and costs $626
Fastest flight from Santo Domingo to Sao Paulo takes 1d 6h 50m
There are no direct flights on this route.
The distance between Santo Domingo and Sao Paulo is 5324km (3301 miles). The time difference between Santo Domingo and Sao Paulo is 1h
We couldn't find any special offers for flights from Santo Domingo to Sao Paulo
The cheapest flight ticket from Santo Domingo to Sao Paulo according to data for the last 48 hours costs $346
Often the best time to buy tickets from Santo Domingo to Sao Paulo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Sao Paulo can be found flying in these months: December, January.
The fastest flights from Santo Domingo to Sao Paulo start from 6 hours 50 minutes in the air.
The following airlines operate direct flights on the route Santo Domingo — Sao Paulo:
In different months, ticket prices from Santo Domingo to Sao Paulo vary: minimum — $351 (December 2025), maximum — $459 (January 2026). Typically, the flight costs $405–$459.