There are most likely no direct flights on the Santiago — Cuzco route
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A non-stop flight is the most convenient and comfortable way to fly from Santiago to Cuzco, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Santiago — Cuzco route
The minimum one-way ticket price from Santiago to Cuzco is $129 (December 2026), while the maximum is $177 (January 2027). On average, a ticket costs $157–$342.
Ticket prices for Santiago — Cuzco follow a predictable curve: rise, peak, and decline. This typical seasonal pattern lets you plan your purchase to avoid overpaying.
Prices rise from December 2026 to January 2027 (+38%), then decline from January 2027 to February 2027 (7%). The cheapest tickets are in December 2026–January 2027 (averaging $153), while the priciest are in January 2027–February 2027 ($171).
For savings, plan your flight for December 2026–January 2027 — you could save up to 10%. Try to avoid January 2027–February 2027 when possible: prices are at their highest then.
Price spread on this route is 13.1%. Costs depend heavily on the season, so flexibility in choosing your departure month is especially valuable here.
Santiago — Cuzco
09/03/2026
Departure
Direct flight
LA2367
starting at $278
Santiago — Cuzco
12/08/2026
Departure
Direct flight
LA2367
starting at $207
Santiago — Cuzco
02/16/2027
Departure
Direct flight
H25628
starting at $222
Santiago — Cuzco
09/28/2026
Departure
Direct flight
LA2367
starting at $271
Santiago — Cuzco
01/01/2027
Departure
Direct flight
LA2367
starting at $335
Santiago — Cuzco
01/05/2027
Departure
Direct flight
LA2367
starting at $210
Santiago — Cuzco
04/17/2027
Departure
Direct flight
LA2367
starting at $189
Santiago — Cuzco
09/01/2026
Departure
Direct flight
LA2367
starting at $184
Santiago — Cuzco
10/07/2026
Departure
Direct flight
LA2367
starting at $266
Santiago — Cuzco
10/08/2026
Departure
Direct flight
LA2367
starting at $267
The route Santiago — Cuzco is served by several airlines: LATAM Chile, Sky Airline, and B&H Airlines. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $121 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Santiago to Cuzco according to data for the last 48 hours costs $121
Often the best time to buy tickets from Santiago to Cuzco is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Cuzco can be found flying in these months: December, February, January.
The fastest flights from Santiago to Cuzco start from 3 hours 30 minutes in the air.
The following airlines operate direct flights on the route Santiago — Cuzco: LATAM Chile, Sky Airline
The cheapest one-way flight from Santiago to Cuzco departs on 12/08/2026, is operated by B&H Airlines and costs $121
The cheapest roundtrip flight from Santiago to Cuzco departs on 12/12/2026, is operated by Sky Airline and costs $262
Fastest flight from Santiago to Cuzco takes 3h 30m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Santiago and Cuzco is 2217km (1375 miles). There are 8 direct flights from Santiago to Cuzco. The time difference between Santiago and Cuzco is 1h. Flights from Santiago begin at 6:10 AM. The latest flight from Santiago departs at 6:10 AM
We couldn't find any special offers for flights from Santiago to Cuzco