Sky Airline
Every day
starting at $50
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santiago to Antofagasta. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Santiago to Antofagasta, despite the fact that sometimes flights with transfers can cost significantly less.
The only airline operating direct flights from Santiago to Antofagasta is Sky Airline. Flights operate every day.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Sky Airline
Every day
starting at $50
The cost of a one-way flight from Santiago to Antofagasta ranges from $20 (August 2026) to $55 (January 2027). On average, the ticket price is about $33–$78.
Prices on the Santiago — Antofagasta route are consistently going up. From August 2026 to January 2027, tickets went from $20 to $55 — a 168% increase. This trend is worth considering when planning your trip.
The most significant price increase was from August 2026 to January 2027 — up 168%. The best time to fly is August 2026–October 2026, when the average price is $22. In October 2026–January 2027, tickets cost around $39.
Given the rising prices, it's best not to delay your purchase. Flying in August 2026–October 2026 can save you up to 44% compared to the most expensive months.
Price variation across months on this route is 47.2%. Your choice of departure month significantly affects the total flight cost.
Santiago — Antofagasta
09/23/2026
Departure
Direct flight
H2270
starting at $96
Santiago — Antofagasta
10/12/2026
Departure
Direct flight
LA136
starting at $120
Santiago — Antofagasta
09/04/2026
Departure
Direct flight
LA126
starting at $51
Santiago — Antofagasta
09/05/2026
Departure
Direct flight
H2286
starting at $91
Santiago — Antofagasta
09/06/2026
Departure
Direct flight
JA54
starting at $219
Santiago — Antofagasta
08/30/2026
Departure
Direct flight
LA130
starting at $285
Flights from Santiago to Antofagasta are operated by several airlines — Sky Airline, LATAM Chile, and B&H Airlines. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $24, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.
The cheapest flight ticket from Santiago to Antofagasta according to data for the last 48 hours costs $24
Often the best time to buy tickets from Santiago to Antofagasta is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Antofagasta can be found flying in these months: August, October, January.
The fastest flights from Santiago to Antofagasta start from 2 hours 2 minutes in the air.
The following airlines operate direct flights on the route Santiago — Antofagasta: Sky Airline, LATAM Chile, B&H Airlines
The cheapest one-way flight from Santiago to Antofagasta departs on 08/29/2026, is operated by B&H Airlines and costs $24
There is no information about the cheapest roundtrip flight from Santiago to Antofagasta
Fastest flight from Santiago to Antofagasta takes 2h 2m
There are direct flights on this route 5 days a week: Su, Mo, We, Fr, and Sa
The distance between Santiago and Antofagasta is 1108km (687 miles). There are 144 direct flights from Santiago to Antofagasta. Santiago and Antofagasta are in the same time zone. Flights from Santiago begin at 4:31 AM. The latest flight from Santiago departs at 10:45 PM
We couldn't find any special offers for flights from Santiago to Antofagasta