Cheap Flights from Santa Cruz to Sao Paulo — $228

The route Santa Cruz — Sao Paulo is served by several airlines: Gol Transportes Aéreos and Boliviana de Aviación. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $228 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.

The distance between Santa Cruz and Sao Paulo is 1836km (1138 miles). The average flight duration is 2h 45m. There are 11 direct flights from Santa Cruz to Sao Paulo. The time difference between Santa Cruz and Sao Paulo is 1h. Flights from Santa Cruz begin at 9:05 AM. The latest flight from Santa Cruz departs at 1:35 PM

The minimum one-way ticket price from Santa Cruz to Sao Paulo is $255 (September 2026), while the maximum is $300 (May 2026). On average, a ticket costs $270–$274.

Santa Cruz de la Sierra is mainly served by Viru Viru International (VVI), the region’s principal international gateway and long-haul hub, while the smaller El Trompillo (SRZ) tends to handle limited domestic and charter services. VVI typically hosts major carriers and international connections and can be pricier on average than domestic-only airports; it lies about 20–30 km (30–45 minutes) east of downtown. Ground options include airport buses, taxis and app-based rideshares with fares varying widely, and private transfers often taking 30–45 minutes depending on traffic. El Trompillo is much closer to the city center (around 5–10 minutes), often cheaper for short hops, but offers fewer flight choices and more basic facilities. Pros: VVI provides broader connectivity and more passenger services; El Trompillo can be more convenient for quick domestic trips.

Fly nonstop from Santa Cruz (VVI) to São Paulo for the quickest, most convenient way to connect Bolivia with Brazil’s bustling gateway — fewer hassles, no layovers, and more time to enjoy your trip. While connecting options can sometimes be cheaper, booking a direct flight saves hours and makes for a much more comfortable journey between the two cities.

São Paulo is served by two main airports with different roles. São Paulo–Guarulhos (GRU) is the international gateway and busiest hub, typically handling most long-haul and full-service carriers as well as some domestic flights; it sits about 25–30 km northeast of the city center and can be reached by bus, airport shuttle, taxi or rideshare in roughly 40–60 minutes depending on traffic (airport buses and shared shuttles usually cost modest fares, while taxis and app cars are pricier). Congonhas (CGH) functions as the city’s domestic and business-focused airport, nearer to downtown at about 8–10 km and reachable in 15–30 minutes; it’s often used by budget and major Brazilian carriers for short hops. Pros of GRU include wide international connections and extensive services, while its distance and traffic can add time; Congonhas offers convenience and quicker access but can be crowded and has more limited long-haul options.