There are most likely no direct flights on the Panama City — Sao Paulo route
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Panama City to Sao Paulo. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
The minimum one-way ticket price from Panama City to Sao Paulo is $273 (September 2026), while the maximum is $444 (August 2026). On average, a ticket costs $332–$632.
A non-stop flight is the most convenient and comfortable way to fly from Panama City to Sao Paulo, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Tickets from Panama City to Sao Paulo are getting more expensive each month. From August 2026 to May 2027, the increase reached 29%, with prices now at $315. It's unlikely to get cheaper than the current level.
The most significant price increase was from September 2026 to May 2027 — up 15%. The best time to fly is September 2026–November 2026, when the average price is $292. In August 2026–September 2026, tickets cost around $358.
Given the rising prices, it's best not to delay your purchase. Flying in September 2026–November 2026 can save you up to 19% compared to the most expensive months.
Price variation across months on this route is 17.6%. Your choice of departure month significantly affects the total flight cost.
There are most likely no direct flights on the Panama City — Sao Paulo route
Panama City is primarily served by Tocumen International Airport (PTY), the region’s main international hub that typically handles long-haul and connecting flights for legacy carriers and major Latin American airlines. A secondary option is Albrook “Marcos A. Gelabert” (PAC), which is usually a domestic and low-cost alternative for short regional hops. Tocumen sits about 24 km (roughly 30–45 minutes by car) from downtown Panama City; taxis and ride-hailing services are common, with fares generally higher than local buses—bus and metro connections can be cheaper but take longer. Albrook is much closer, often 5–15 minutes to the city center by taxi or a short bus ride. Pros: Tocumen offers extensive international connections and amenities; Albrook is convenient for quick domestic trips. Cons: Tocumen can feel busy and farther from the city, while Albrook has limited international service and fewer facilities.
São Paulo is served by two main airports with different roles. São Paulo–Guarulhos International (GRU) is the primary international hub, typically handling most long-haul and full-service carriers such as LATAM, Gol’s international partners, and various global airlines; it’s about 25–30 km (roughly 40–50 minutes by road) from downtown, reachable by airport bus, taxi/Ride-hailing or the airport rail link with fares usually in the low to mid-range for public transport. Congonhas (CGH) functions more as a domestic/business-oriented airport favored by short-haul and legacy carriers; it sits much closer to the city (around 8 km, 15–25 minutes by car) and can be faster for business trips. GRU can be more comprehensive but busier and sometimes pricier, while Congonhas offers convenience for central arrivals but is limited in international connections.
Panama City — Sao Paulo
08/11/2026
Departure
Direct flight
CM759
starting at $903
Panama City — Sao Paulo
08/11/2026
Departure
Direct flight
CM701
starting at $693
Panama City — Sao Paulo
08/26/2026
Departure
Direct flight
CM701
starting at $777
Panama City — Sao Paulo
05/17/2027
Departure
Direct flight
CM725
starting at $947
starting at $444
starting at $276
The route Panama City — Sao Paulo is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $276 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Panama City to Sao Paulo according to data for the last 48 hours costs $276
Often the best time to buy tickets from Panama City to Sao Paulo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Sao Paulo can be found flying in these months: September, November, May.
The fastest flights from Panama City to Sao Paulo start from 9 hours 40 minutes in the air.
The following airlines operate direct flights on the route Panama City — Sao Paulo: Copa Airlines
The cheapest one-way flight from Panama City to Sao Paulo departs on 08/11/2026, is operated by Avianca and costs $276
The cheapest roundtrip flight from Panama City to Sao Paulo departs on 09/22/2026, is operated by Avianca and costs $507
Fastest flight from Panama City to Sao Paulo takes 9h 40m
There are direct flights on this route 3 days a week: Mo, Tu, and We
The distance between Panama City and Sao Paulo is 5089km (3155 miles). There are 10 direct flights from Panama City to Sao Paulo. The time difference between Panama City and Sao Paulo is 2h. Flights from Panama City begin at 12:00 PM. The latest flight from Panama City departs at 9:40 PM
We couldn't find any special offers for flights from Panama City to Sao Paulo