Starting at $213
Helping travelers to find the best flight offers
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Guatemala City:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Starting at $213
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Panama City to Guatemala City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
Below you will find a list of airlines operating flights on the Panama City — Guatemala City route and the starting prices for flights of each specific airline on it.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Panama City to Guatemala City
A direct flight is the most convenient and comfortable way to fly from Panama City to Guatemala City, despite the fact that sometimes flights with transfers can cost significantly less.
Copa Airlines
Every day
Starting at $502
The cheapest one-way flight from Panama City to Guatemala City departs on 11/02/2025, is operated by Avianca and costs $167
The cheapest roundtrip flight from Panama City to Guatemala City departs on 04/05/2025, is operated by Copa Airlines and costs $278
Fastest flight from Panama City to Guatemala City takes 2h 25m
There are direct flights on this route 2 days a week: Mo and Sa
The distance between Panama City and Guatemala City is 1349km (836 miles). The average flight duration is 2h 27m. There are 38 direct flights from Panama City to Guatemala City. The time difference between Panama City and Guatemala City is 1h . Flights from Panama City begin at 7:27 AM. The latest flight from Panama City departs at 9:21 PM.
Panama City — Guatemala City
03/29/2025
Departure date
Direct flight
CM391
Starting at $243
Panama City — Guatemala City
03/31/2025
Departure date
Direct flight
CM391
Starting at $186
Panama City — Guatemala City
04/20/2025
Departure date
Direct flight
CM102
Starting at $580
Panama City — Guatemala City
04/30/2025
Departure date
Direct flight
CM358
Starting at $186
Panama City — Guatemala City
05/01/2025
Departure date
Direct flight
CM391
Starting at $186
Panama City — Guatemala City
06/02/2025
Departure date
Direct flight
CM391
Starting at $262
Panama City — Guatemala City
10/27/2025
Departure date
Direct flight
CM358
Starting at $175
Panama City — Guatemala City
11/02/2025
Departure date
Direct flight
CM358
Starting at $447
The cheapest flight ticket from Panama City to Guatemala City according to data for the last 48 hours costs $167
Often the best time to buy tickets from Panama City to Guatemala City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Guatemala City can be found flying in these months: March, November, April.
The fastest flights from Panama City to Guatemala City start from 2 hours 25 minutes in the air.
The following airlines operate direct flights on the route Panama City — Guatemala City: Copa Airlines
March 31
Copa Airlines
