Asian Air
Mo, We, Th, and Fr
starting at $325
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Mexico City to Santo Domingo. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Mexico City to Santo Domingo, despite the fact that sometimes flights with transfers can cost significantly less.
The only airline operating direct flights from Mexico City to Santo Domingo is Asian Air. Flights operate on Monday, Wednesday, Thursday, and Friday.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Asian Air
Mo, We, Th, and Fr
starting at $325
We couldn't find any special offers for flights from Mexico City to Santo Domingo
In different months, ticket prices from Mexico City to Santo Domingo vary: minimum — $198 (January 2027), maximum — $276 (November 2026). Typically, the flight costs $242–$529.
On the Mexico City — Santo Domingo route, prices first decline, hit a low, then start rising again. The middle of the period creates a price window — the best time to book.
Prices fall from November 2026 to January 2027 (28%), then rise from September 2026 to November 2026 (+9%). The best period is November 2026–January 2027 ($237), the most expensive is September 2026–November 2026 ($264).
The best time to buy is November 2026–January 2027, when prices are at their lowest. This can save you up to 10% compared to the expensive months (September 2026–November 2026).
Monthly price variation is 13.5%. On this route, your departure date noticeably affects the cost, and choosing wisely can lead to real savings.
Mexico City — Santo Domingo
10/01/2026
Departure
Direct flight
DM4163
starting at $264
Mexico City — Santo Domingo
10/03/2026
Departure
Direct flight
AM654
starting at $241
Mexico City — Santo Domingo
10/04/2026
Departure
Direct flight
AM654
starting at $241
Mexico City — Santo Domingo
10/27/2026
Departure
Direct flight
AM654
starting at $376
Mexico City — Santo Domingo
09/13/2026
Departure
Direct flight
AM654
starting at $415
Mexico City — Santo Domingo
11/17/2026
Departure
Direct flight
DM4163
starting at $189
Mexico City — Santo Domingo
02/03/2027
Departure
Direct flight
AM654
starting at $475
Mexico City — Santo Domingo
02/05/2027
Departure
Direct flight
DM4165
starting at $151
Mexico City — Santo Domingo
10/17/2026
Departure
Direct flight
AM654
starting at $232
The Mexico City — Santo Domingo route is served by multiple airlines, including Asian Air, Aeromexico, and VivaAerobus. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $151, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
The cheapest flight ticket from Mexico City to Santo Domingo according to data for the last 48 hours costs $151
Often the best time to buy tickets from Mexico City to Santo Domingo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Santo Domingo can be found flying in these months: January, September, November.
The fastest flights from Mexico City to Santo Domingo start from 4 hours 15 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Santo Domingo: Asian Air, Aeromexico
The cheapest one-way flight from Mexico City to Santo Domingo departs on 02/04/2027, is operated by Asian Air and costs $151
There is no information about the cheapest roundtrip flight from Mexico City to Santo Domingo
Fastest flight from Mexico City to Santo Domingo takes 4h 15m
There are direct flights on this route 6 days a week: Su, Tu, We, Th, Fr, and Sa
The distance between Mexico City and Santo Domingo is 3068km (1902 miles). There are 8 direct flights from Mexico City to Santo Domingo. The time difference between Mexico City and Santo Domingo is 2h. Flights from Mexico City begin at 11:34 PM. The latest flight from Mexico City departs at 12:15 AM
