There are most likely no direct flights on the Mexico City — Santo Domingo route
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A non-stop flight is the most convenient and comfortable way to fly from Mexico City to Santo Domingo, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Mexico City — Santo Domingo route
In different months, ticket prices from Mexico City to Santo Domingo vary: minimum — $199 (June 2026), maximum — $307 (July 2026). Typically, the flight costs $253–$307.
Mexico City — Santo Domingo
06/28/2026
Departure
Direct flight
AM654
starting at $412
Mexico City — Santo Domingo
07/25/2026
Departure
Direct flight
AM654
starting at $304
Mexico City — Santo Domingo
07/26/2026
Departure
Direct flight
AM654
starting at $492
Mexico City — Santo Domingo
06/16/2026
Departure
Direct flight
AM654
starting at $456
Mexico City — Santo Domingo
06/18/2026
Departure
Direct flight
DM4163
starting at $257
Mexico City — Santo Domingo
06/07/2026
Departure
Direct flight
AM654
starting at $391
Mexico City — Santo Domingo
06/13/2026
Departure
Direct flight
DM4163
starting at $240
Mexico City — Santo Domingo
06/19/2026
Departure
Direct flight
AM654
starting at $335
Mexico City — Santo Domingo
06/22/2026
Departure
Direct flight
AM654
starting at $457
starting at $304
starting at $199
starting at $211
starting at $278
starting at $336
The route Mexico City — Santo Domingo is served by many carriers — 5 in total, including Aeromexico, Asian Air, Avianca, Copa Airlines, and VivaAerobus. This gives passengers wide opportunities: from finding the lowest fare (from $199) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
The cheapest flight ticket from Mexico City to Santo Domingo according to data for the last 48 hours costs $199
Often the best time to buy tickets from Mexico City to Santo Domingo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Santo Domingo can be found flying in these months: June, July.
The fastest flights from Mexico City to Santo Domingo start from 4 hours 25 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Santo Domingo: Aeromexico, Asian Air
The cheapest one-way flight from Mexico City to Santo Domingo departs on 06/18/2026, is operated by Asian Air and costs $199
There is no information about the cheapest roundtrip flight from Mexico City to Santo Domingo
Fastest flight from Mexico City to Santo Domingo takes 4h 25m
There are direct flights on this route 6 days a week: Su, Mo, Tu, Th, Fr, and Sa
The distance between Mexico City and Santo Domingo is 3062km (1898 miles). There are 9 direct flights from Mexico City to Santo Domingo. The time difference between Mexico City and Santo Domingo is 2h. Flights from Mexico City begin at 11:34 PM. The latest flight from Mexico City departs at 12:20 AM
We couldn't find any special offers for flights from Mexico City to Santo Domingo
