Cheap Flights from Mexico City to Santa Cruz — $268

On the Mexico City — Santa Cruz route, flights are operated only by Avianca. This simplifies the choice for passengers, as all tickets come from a single trusted carrier. Our service lets you instantly check fares for upcoming dates and find the most advantageous option. The minimum ticket price starts at $268, making this trip affordable for a wide range of travelers. To save even more, we recommend booking early and keeping an eye on promotions — Avianca regularly offers special deals.

Mexico City is served primarily by Benito Juárez International (MEX), the country’s main international hub handling most long-haul and domestic flights, and by Felipe Ángeles International (AIFA), a newer airport positioned for budget and overflow traffic. MEX is a major base for full-service carriers and Oneworld/Star Alliance partners, while AIFA commonly hosts low-cost airlines and some domestic services; fares at AIFA can sometimes be lower but vary by carrier and timing. Benito Juárez sits about 13 km east of the historic center — Metro, metrobus and taxis reach downtown in roughly 20–40 minutes (fares range from a few pesos for transit to moderate taxi/Uber rates). AIFA is farther north, typically 40–60 minutes by road from central districts, with shuttle buses and rideshares available for modest to moderate costs. Pros: MEX offers extensive connections and frequent public transit; AIFA can be less congested and cheaper. Cons: both can be busy at peak times and AIFA’s greater distance may add transfer time and cost.

Viru Viru International (VVI) is Sucre’s main international gateway and typically functions as Bolivia’s largest airport in the east, handling most long-haul and regional connections operated by full-service and a few low-cost carriers. It sits about 15–20 km northwest of Santa Cruz’s city centre, with road transfers usually taking 20–40 minutes depending on traffic; shared taxis, airport shuttles and private transfers are normally available, with fares often ranging from modest flat rates to mid-range taxi fees. The airport is generally more comfortable and better equipped for international travel than smaller domestic fields, though transfer times into central Santa Cruz can be longer during peak hours. For domestic connections, nearby Viru Viru can be convenient but may feel busier and pricier than smaller regional alternatives.

The cost of a one-way flight from Mexico City to Santa Cruz ranges from $268 (April 2026) to $272 (March 2026). On average, the ticket price is about $270–$272.