Unable to find information about the schedule of direct flights from
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Madrid to Panama City:
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Answers to questions about the route that travelers are most interested in.
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Unable to find information about the schedule of direct flights from
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
Madrid — Panama City
05/23/2026
Departure
Direct flight
UX55
starting at $512
Madrid — Panama City
07/01/2026
Departure
Direct flight
IB257
starting at $937
Madrid — Panama City
07/24/2026
Departure
Direct flight
UX55
starting at $869
Madrid — Panama City
11/04/2026
Departure
Direct flight
UX55
starting at $692
Madrid — Panama City
05/10/2026
Departure
Direct flight
UX55
starting at $363
Madrid — Panama City
07/19/2026
Departure
Direct flight
UX55
starting at $784
Flights from Madrid to Panama City are operated by several airlines — Air Europa, Iberia, and Avianca. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $363, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.
The cheapest one-way flight from Madrid to Panama City departs on 05/10/2026, is operated by Air Europa and costs $363
The cheapest roundtrip flight from Madrid to Panama City departs on 05/12/2026, is operated by Air Europa and costs $717
Fastest flight from Madrid to Panama City takes 10h 35m
There are direct flights on this route 4 days a week: Su, We, Fr, and Sa
The distance between Madrid and Panama City is 8161km (5060 miles). The average flight duration is 10h 35m. There are 11 direct flights from Madrid to Panama City. The time difference between Madrid and Panama City is 6h. Flights from Madrid begin at 3:05 PM. The latest flight from Madrid departs at 3:55 PM
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
The cheapest flight ticket from Madrid to Panama City according to data for the last 48 hours costs $363
Often the best time to buy tickets from Madrid to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Panama City can be found flying in these months: May, April, August.
The fastest flights from Madrid to Panama City start from 10 hours 35 minutes in the air.
The following airlines operate direct flights on the route Madrid — Panama City: Air Europa, Iberia
The cost of a one-way flight from Madrid to Panama City ranges from $285 (May 2026) to $548 (July 2026). On average, the ticket price is about $355–$657.
Flight prices from Madrid to Panama City are steadily rising: from April 2026 to August 2026, ticket costs increased by 7%. The sooner you book, the better the deal.
The most significant price increase was from April 2026 to July 2026 — up 90%. The best time to fly is April 2026–May 2026, when the average price is $286. In June 2026–July 2026, tickets cost around $448.
Given the rising prices, it's best not to delay your purchase. Flying in April 2026–May 2026 can save you up to 36% compared to the most expensive months.
Price variation across months on this route is 27.8%. Your choice of departure month significantly affects the total flight cost.
We couldn't find any special offers for flights from Madrid to Panama City
