Starting at $547
Starting at $491
Starting at $470
Starting at $521
Starting at $534
Starting at $554
Starting at $559
Helping travelers to find the best flight offers
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the most convenient and comfortable way to fly from Madrid to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Madrid to Panama City:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
More than 7 airlines operate flights from Madrid to Panama City, including Air Europa, Iberia, Ryanair, TAP Portugal, ITA Airways, LC Busre SAC, and Avianca. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $470, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
Starting at $547
Starting at $491
Starting at $470
Starting at $521
Starting at $534
Starting at $554
Starting at $559
Madrid — Panama City
10/24/2025
Departure
Direct flight
UX55
Starting at $969
Madrid — Panama City
11/03/2025
Departure
Direct flight
IB257
Starting at $832
Madrid — Panama City
01/12/2026
Departure
Direct flight
IB257
Starting at $971
Madrid — Panama City
01/22/2026
Departure
Direct flight
UX55
Starting at $547
Madrid — Panama City
01/24/2026
Departure
Direct flight
IB257
Starting at $669
Madrid — Panama City
02/14/2026
Departure
Direct flight
IB257
Starting at $752
Madrid — Panama City
02/15/2026
Departure
Direct flight
UX55
Starting at $650
Madrid — Panama City
10/20/2025
Departure
Direct flight
UX55
Starting at $1,302
Madrid — Panama City
10/25/2025
Departure
Direct flight
UX55
Starting at $1,151
Madrid — Panama City
11/22/2025
Departure
Direct flight
IB257
Starting at $607
Air Europa
Every day
Starting at $355
The cheapest flight ticket from Madrid to Panama City according to data for the last 48 hours costs $470
Often the best time to buy tickets from Madrid to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Panama City can be found flying in these months: November, October, December.
The fastest flights from Madrid to Panama City start from 10 hours 35 minutes in the air.
The following airlines operate direct flights on the route Madrid — Panama City: Air Europa, Iberia
The cost of a one-way flight from Madrid to Panama City ranges from $389 (November 2025) to $572 (December 2025). On average, the ticket price is about $450–$963.
The cheapest one-way flight from Madrid to Panama City departs on 11/22/2025, is operated by Ryanair and costs $470
The cheapest roundtrip flight from Madrid to Panama City departs on 02/26/2026, is operated by Air Europa and costs $789
Fastest flight from Madrid to Panama City takes 10h 35m
There are direct flights on this route 1 day a week: Su
The distance between Madrid and Panama City is 8161km (5060 miles). The average flight duration is 10h 35m. There are 15 direct flights from Madrid to Panama City. The time difference between Madrid and Panama City is 6h. Flights from Madrid begin at 11:40 AM. The latest flight from Madrid departs at 3:10 PM
We couldn't find any special offers for flights from Madrid to Panama City
