There are most likely no direct flights on the Madrid — Panama City route
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
The cost of a one-way flight from Madrid to Panama City ranges from $374 (June 2026) to $713 (July 2026). On average, the ticket price is about $502–$1,043.
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Prices on the Madrid — Panama City route are unpredictable: costs change from month to month with no clear pattern. Still, even here some periods are more affordable than others.
Despite the fluctuations, patterns exist: the cheapest period is August 2026–November 2026 — averaging $508. The most expensive is July 2026–August 2026 ($548). The difference reaches 7%.
With this kind of price behavior, it's worth comparing prices across several months and booking when a good deal appears. A good benchmark is August 2026–November 2026, where you can save up to 7%.
Price spread on this route is 28.3%. Costs vary significantly, so your choice of month can noticeably affect your travel budget.
There are most likely no direct flights on the Madrid — Panama City route
Madrid — Panama City
06/16/2026
Departure
Direct flight
UX55
starting at $667
Madrid — Panama City
06/21/2026
Departure
Direct flight
UX55
starting at $1,048
Madrid — Panama City
11/25/2026
Departure
Direct flight
UX55
starting at $694
Madrid — Panama City
07/24/2026
Departure
Direct flight
UX55
starting at $876
Madrid — Panama City
03/01/2027
Departure
Direct flight
UX55
starting at $758
Madrid — Panama City
08/01/2026
Departure
Direct flight
UX55
starting at $1,307
Madrid — Panama City
08/03/2026
Departure
Direct flight
UX55
starting at $1,118
Madrid — Panama City
08/04/2026
Departure
Direct flight
UX55
starting at $1,031
Madrid — Panama City
08/19/2026
Departure
Direct flight
UX55
starting at $625
Madrid — Panama City
07/01/2026
Departure
Direct flight
UX055
starting at $811
starting at $625
starting at $409
starting at $414
starting at $487
starting at $713
starting at $850
starting at $1,068
More than 7 airlines operate flights from Madrid to Panama City, including Air Europa, Avianca, Wamos Air, Iberia, Welcome Air, Aeromexico, and LC Busre SAC. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $409, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
The cheapest flight ticket from Madrid to Panama City according to data for the last 48 hours costs $409
Often the best time to buy tickets from Madrid to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Panama City can be found flying in these months: June, August, March.
The fastest flights from Madrid to Panama City start from 10 hours 35 minutes in the air.
The following airlines operate direct flights on the route Madrid — Panama City: Air Europa
The cheapest one-way flight from Madrid to Panama City departs on 03/01/2027, is operated by Avianca and costs $409
The cheapest roundtrip flight from Madrid to Panama City departs on 09/02/2026, is operated by Iberia and costs $699
Fastest flight from Madrid to Panama City takes 10h 35m
There are direct flights on this route 6 days a week: Su, Mo, Tu, We, Fr, and Sa
The distance between Madrid and Panama City is 8161km (5060 miles). The average flight duration is 10h 35m. There are 11 direct flights from Madrid to Panama City. The time difference between Madrid and Panama City is 6h. Flights from Madrid begin at 3:05 PM. The latest flight from Madrid departs at 3:55 PM
