There are most likely no direct flights on the Madrid — Panama City route
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
•
•
•
•
•
•
Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
All airports
There are most likely no direct flights on the Madrid — Panama City route
Good news for anyone planning a flight from Madrid to Panama City: prices are steadily declining. From November 2026 to May 2027, tickets dropped by 47%, and the trend continues.
The most notable drop occurred from November 2026 to April 2027 — down 50%. The best period is March 2027–April 2027 (averaging $323), while the most expensive is November 2026–December 2026 ($638).
Since prices are falling, there's no rush to buy. The most cost-effective travel period is March 2027–April 2027: savings compared to expensive months can reach up to 49%.
Monthly price variation is 33.5%. Choosing the right departure date can lead to significant savings on this route.
The cost of a one-way flight from Madrid to Panama City ranges from $322 (March 2027) to $639 (November 2026). On average, the ticket price is about $452–$977.
Madrid — Panama City
03/26/2027
Departure
Direct flight
IB257
starting at $575
Madrid — Panama City
11/18/2026
Departure
Direct flight
UX055
starting at $1,007
Madrid — Panama City
01/24/2027
Departure
Direct flight
UX55
starting at $625
Madrid — Panama City
12/09/2026
Departure
Direct flight
UX55
starting at $629
Madrid — Panama City
02/20/2027
Departure
Direct flight
UX55
starting at $667
Madrid — Panama City
12/28/2026
Departure
Direct flight
UX55
starting at $824
Madrid — Panama City
12/29/2026
Departure
Direct flight
UX55
starting at $824
Madrid — Panama City
11/11/2026
Departure
Direct flight
IB257
starting at $911
Madrid — Panama City
11/19/2026
Departure
Direct flight
UX55
starting at $906
Madrid — Panama City
12/14/2026
Departure
Direct flight
UX55
starting at $1,034
starting at $520
starting at $614
starting at $291
starting at $626
starting at $639
starting at $702
starting at $724
starting at $743
More than 8 airlines operate flights from Madrid to Panama City, including Iberia, Air Europa, Avianca, Air France, British Airways, Wizz Air, LC Busre SAC, and Transavia. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $291, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
The cheapest flight ticket from Madrid to Panama City according to data for the last 48 hours costs $291
Often the best time to buy tickets from Madrid to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Panama City can be found flying in these months: March, April, May.
The fastest flights from Madrid to Panama City start from 10 hours 35 minutes in the air.
The following airlines operate direct flights on the route Madrid — Panama City: Iberia, Air Europa
The cheapest one-way flight from Madrid to Panama City departs on 02/02/2027, is operated by Avianca and costs $291
The cheapest roundtrip flight from Madrid to Panama City departs on 02/20/2027, is operated by Avianca and costs $545
Fastest flight from Madrid to Panama City takes 10h 35m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Madrid and Panama City is 8161km (5060 miles). There are 14 direct flights from Madrid to Panama City. The time difference between Madrid and Panama City is 6h. Flights from Madrid begin at 12:00 PM. The latest flight from Madrid departs at 3:10 PM
We couldn't find any special offers for flights from Madrid to Panama City
