Air Europa
Every day
Starting at $379
Helping travelers to find the best flight offers
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Madrid to Panama City:
•
•
•
•
•
•
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Air Europa
Every day
Starting at $379
A direct flight is the most convenient and comfortable way to fly from Madrid to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
The cheapest one-way flight from Madrid to Panama City departs on 01/22/2026, is operated by Avianca and costs $452
The cheapest roundtrip flight from Madrid to Panama City departs on 01/25/2026, is operated by Air Europa and costs $696
Fastest flight from Madrid to Panama City takes 16h 20m
There are no direct flights on this route.
The distance between Madrid and Panama City is 8161km (5060 miles). The average flight duration is 10h 35m. There are 15 direct flights from Madrid to Panama City. The time difference between Madrid and Panama City is 6h. Flights from Madrid begin at 11:40 AM. The latest flight from Madrid departs at 3:10 PM
Madrid — Panama City
12/10/2025
Departure
Direct flight
IB257
Starting at $2,526
Madrid — Panama City
12/13/2025
Departure
Direct flight
UX55
Starting at $1,188
Madrid — Panama City
12/14/2025
Departure
Direct flight
UX55
Starting at $1,188
Madrid — Panama City
12/16/2025
Departure
Direct flight
UX055
Starting at $886
Madrid — Panama City
12/21/2025
Departure
Direct flight
UX055
Starting at $1,152
Madrid — Panama City
01/01/2026
Departure
Direct flight
UX55
Starting at $821
Madrid — Panama City
01/02/2026
Departure
Direct flight
UX55
Starting at $1,098
Madrid — Panama City
01/08/2026
Departure
Direct flight
UX55
Starting at $977
Madrid — Panama City
01/10/2026
Departure
Direct flight
UX55
Starting at $882
Madrid — Panama City
01/11/2026
Departure
Direct flight
UX55
Starting at $867
More than 9 airlines operate flights from Madrid to Panama City, including Iberia, Air Europa, Avianca, TAP Portugal, Orbest, Ryanair, American Airlines, Vueling, and Welcome Air. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $452, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
Starting at $701
Starting at $626
Starting at $452
Starting at $525
Starting at $677
Starting at $678
Starting at $726
Starting at $763
Starting at $1,105
We couldn't find any special offers for flights from Madrid to Panama City
The cheapest flight ticket from Madrid to Panama City according to data for the last 48 hours costs $452
Often the best time to buy tickets from Madrid to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Panama City can be found flying in these months: January, February, December.
The fastest flights from Madrid to Panama City start from 16 hours 20 minutes in the air.
The following airlines operate direct flights on the route Madrid — Panama City: Iberia, Air Europa
The cost of a one-way flight from Madrid to Panama City ranges from $313 (January 2026) to $623 (December 2025). On average, the ticket price is about $487–$1,148.
