starting at $551
starting at $581
starting at $337
starting at $337
starting at $562
Compare airlines, prices, and flight durations for your trip
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Madrid to Panama City:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
More than 5 airlines operate flights from Madrid to Panama City, including Air Europa, Iberia, Air Ocean, Avianca, and TAP Portugal. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $337, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
starting at $551
starting at $581
starting at $337
starting at $337
starting at $562
Madrid — Panama City
01/21/2026
Departure
Direct flight
UX55
starting at $738
Madrid — Panama City
01/22/2026
Departure
Direct flight
UX55
starting at $1,141
Madrid — Panama City
01/27/2026
Departure
Direct flight
UX55
starting at $651
Madrid — Panama City
02/07/2026
Departure
Direct flight
UX55
starting at $750
Madrid — Panama City
02/11/2026
Departure
Direct flight
UX55
starting at $595
Madrid — Panama City
02/23/2026
Departure
Direct flight
IB257
starting at $668
Madrid — Panama City
03/08/2026
Departure
Direct flight
UX55
starting at $579
Madrid — Panama City
03/24/2026
Departure
Direct flight
UX55
starting at $551
Madrid — Panama City
05/01/2026
Departure
Direct flight
UX55
starting at $564
Madrid — Panama City
08/01/2026
Departure
Direct flight
UX55
starting at $895
Air Europa
Every day
starting at $569
Iberia
Mo and We
starting at $676
The cheapest one-way flight from Madrid to Panama City departs on 03/24/2026, is operated by Air Ocean and costs $337
The cheapest roundtrip flight from Madrid to Panama City departs on 09/14/2026, is operated by Air Europa and costs $665
Fastest flight from Madrid to Panama City takes 13h 25m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Madrid and Panama City is 8161km (5060 miles). There are 20 direct flights from Madrid to Panama City. The time difference between Madrid and Panama City is 6h. Flights from Madrid begin at 11:40 AM. The latest flight from Madrid departs at 3:10 PM
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
The cheapest flight ticket from Madrid to Panama City according to data for the last 48 hours costs $337
Often the best time to buy tickets from Madrid to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Panama City can be found flying in these months: January, February.
The fastest flights from Madrid to Panama City start from 13 hours 25 minutes in the air.
The following airlines operate direct flights on the route Madrid — Panama City: Air Europa, Iberia
The cost of a one-way flight from Madrid to Panama City ranges from $369 (January 2026) to $379 (February 2026). On average, the ticket price is about $374–$379.
We couldn't find any special offers for flights from Madrid to Panama City