starting at $593
starting at $673
starting at $456
starting at $642
starting at $696
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
More than 5 airlines operate flights from Madrid to Panama City, including Air Europa, Iberia, Avianca, Ryanair, and Aeromexico. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $456, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
starting at $593
starting at $673
starting at $456
starting at $642
starting at $696
Madrid — Panama City
09/12/2026
Departure
Direct flight
UX55
starting at $593
Madrid — Panama City
10/05/2026
Departure
Direct flight
UX55
starting at $651
Madrid — Panama City
10/14/2026
Departure
Direct flight
IB257
starting at $673
Madrid — Panama City
11/20/2026
Departure
Direct flight
IB257
starting at $673
Madrid — Panama City
11/25/2026
Departure
Direct flight
IB257
starting at $674
Madrid — Panama City
11/16/2026
Departure
Direct flight
UX55
starting at $677
Madrid — Panama City
11/17/2026
Departure
Direct flight
UX55
starting at $677
Madrid — Panama City
12/08/2026
Departure
Direct flight
UX55
starting at $677
Madrid — Panama City
10/31/2026
Departure
Direct flight
UX55
starting at $685
Madrid — Panama City
10/13/2026
Departure
Direct flight
UX55
starting at $690
Air Europa
Every day
starting at $336
The only airline operating direct flights from Madrid to Panama City is Air Europa. Flights operate every day.
The cheapest one-way flight from Madrid to Panama City departs on 01/29/2027, is operated by Avianca and costs $456
The cheapest roundtrip flight from Madrid to Panama City departs on 11/17/2026, is operated by Air Europa and costs $608
Fastest flight from Madrid to Panama City takes 10h 35m
There are direct flights on this route 5 days a week: Mo, Tu, We, Fr, and Sa
The distance between Madrid and Panama City is 8161km (5060 miles). There are 19 direct flights from Madrid to Panama City. The time difference between Madrid and Panama City is 6h. Flights from Madrid begin at 3:05 PM. The latest flight from Madrid departs at 4:35 PM
The cheapest flight ticket from Madrid to Panama City according to data for the last 48 hours costs $456
Often the best time to buy tickets from Madrid to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Panama City can be found flying in these months: February, September, January.
The fastest flights from Madrid to Panama City start from 10 hours 35 minutes in the air.
The following airlines operate direct flights on the route Madrid — Panama City: Air Europa, Iberia
The cost of a one-way flight from Madrid to Panama City ranges from $327 (February 2027) to $619 (December 2026). On average, the ticket price is about $430–$773.
Prices on the Madrid — Panama City route are unpredictable: costs change from month to month with no clear pattern. Still, even here some periods are more affordable than others.
Despite the fluctuations, patterns exist: the cheapest period is January 2027–February 2027 — averaging $343. The most expensive is November 2026–December 2026 ($513). The difference reaches 33%.
With this kind of price behavior, it's worth comparing prices across several months and booking when a good deal appears. A good benchmark is January 2027–February 2027, where you can save up to 33%.
Price spread on this route is 25.1%. Costs vary significantly, so your choice of month can noticeably affect your travel budget.
We couldn't find any special offers for flights from Madrid to Panama City