There are most likely no direct flights on the Madrid — Guayaquil route
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A non-stop flight is the most convenient and comfortable way to fly from Madrid to Guayaquil, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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The cost of a one-way flight from Madrid to Guayaquil ranges from $509 (January 2027) to $578 (December 2026). On average, the ticket price is about $544–$578.
There are most likely no direct flights on the Madrid — Guayaquil route
Madrid — Guayaquil
12/30/2026
Departure
Direct flight
UX039
starting at $803
Madrid — Guayaquil
12/29/2026
Departure
Direct flight
IB131
starting at $903
Madrid — Guayaquil
12/18/2026
Departure
Direct flight
UX39
starting at $1,133
Flights from Madrid to Guayaquil are operated by several airlines — Air Europa, Iberia, and Avianca. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $588, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.
The cheapest flight ticket from Madrid to Guayaquil according to data for the last 48 hours costs $588
Often the best time to buy tickets from Madrid to Guayaquil is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Guayaquil can be found flying in these months: January, December.
The fastest flights from Madrid to Guayaquil start from 14 hours 15 minutes in the air.
The following airlines operate direct flights on the route Madrid — Guayaquil: Air Europa, Iberia
The cheapest one-way flight from Madrid to Guayaquil departs on 12/30/2026, is operated by Avianca and costs $588
The cheapest roundtrip flight from Madrid to Guayaquil departs on 02/14/2027, is operated by Avianca and costs $703
Fastest flight from Madrid to Guayaquil takes 14h 15m
There are direct flights on this route 3 days a week: Tu, We, and Fr
The distance between Madrid and Guayaquil is 9003km (5582 miles). There are 10 direct flights from Madrid to Guayaquil. The time difference between Madrid and Guayaquil is 6h. Flights from Madrid begin at 12:50 PM. The latest flight from Madrid departs at 1:45 AM
We couldn't find any special offers for flights from Madrid to Guayaquil