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Fly from Guayaquil to Panama City with confidence — our search scans over 700 airlines, 50+ travel agencies, and more than 5 top booking systems to find the best prices, schedules, and booking conditions for your trip. Compare options in seconds and pick the flight that fits your budget and timing, then book quickly to secure the deal.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Guayaquil to Panama City:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The route Guayaquil — Panama City is served by several airlines: Copa Airlines, Air Ocean, and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $162 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
Guayaquil — Panama City
01/16/2026
Departure
Direct flight
CM272
starting at $307
Guayaquil — Panama City
01/24/2026
Departure
Direct flight
CM300
starting at $400
Copa Airlines
Every day
starting at $228
The cheapest one-way flight from Guayaquil to Panama City departs on 01/16/2026, is operated by Air Ocean and costs $162
There is no information about the cheapest roundtrip flight from Guayaquil to Panama City
Fastest flight from Guayaquil to Panama City takes 13h 25m
There are direct flights on this route 2 days a week: Fr and Sa
The distance between Guayaquil and Panama City is 1238km (768 miles). The average flight duration is 5h 25m. There are 48 direct flights from Guayaquil to Panama City. Guayaquil and Panama City are in the same time zone. Flights from Guayaquil begin at 4:28 AM. The latest flight from Guayaquil departs at 3:35 AM
José Joaquín de Olmedo International Airport (GYE) is Ecuador’s main gateway on the Pacific coast, serving both international flights and a busy mix of domestic services; it typically hosts full-service carriers as well as regional and low-cost operators. Located about 4–6 km northwest of central Guayaquil, the airport can be reached by taxi or rideshare in roughly 15–25 minutes depending on traffic, with fares commonly in a moderate range; public buses and airport shuttles provide lower-cost options though travel times can be longer. Facilities are usually compact but functional, offering basic dining and shopping; pros include proximity to the city and good domestic connections, while cons can be congestion at peak times and limited premium-lounge choices.
Fly nonstop from Guayaquil to Panama City for the quickest, most convenient way to get between these vibrant cities — less travel time, fewer hassles, and more time to enjoy Panama’s sights. While connecting options can sometimes be cheaper, a direct flight means greater comfort and a simpler schedule, making it ideal for tight itineraries or relaxed travel plans.
Tocumen International Airport (PTY) serves as Panama City’s main international gateway and regional hub, handling most long-haul and connecting flights with carriers such as Copa, American, and LATAM. It’s typically perceived as a mid-to-upper range airport with a wide choice of lounges, shops and transit connections. The airport lies about 24 km (roughly 30–45 minutes by road) from the historic Casco Viejo; taxis, ride-hailing services and airport shuttles are common, with fares that can vary from economical shared shuttles to higher-cost private transfers. Pros: extensive international connections and decent passenger facilities. Cons: can be busy at peak times and ground transfers may be impacted by city traffic.
We couldn't find any special offers for flights from Guayaquil to Panama City
The cheapest flight ticket from Guayaquil to Panama City according to data for the last 48 hours costs $162
Often the best time to buy tickets from Guayaquil to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Guayaquil to Panama City can be found flying in these months: January.
The fastest flights from Guayaquil to Panama City start from 13 hours 25 minutes in the air.
The following airlines operate direct flights on the route Guayaquil — Panama City: Copa Airlines
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Guayaquil to Panama City
