Cheap Flights from Guayaquil to Panama City — $144

The route Guayaquil — Panama City is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $144 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.

Fly from Guayaquil to Panama City with confidence — our search scans over 700 airlines, 50+ travel agencies, and more than 5 top booking systems to find the best prices, schedules, and booking conditions for your trip. Compare options in seconds and pick the flight that fits your budget and timing, then book quickly to secure the deal.

José Joaquín de Olmedo International Airport (GYE) is Ecuador’s main gateway on the Pacific coast, serving both international flights and a busy mix of domestic services; it typically hosts full-service carriers as well as regional and low-cost operators. Located about 4–6 km northwest of central Guayaquil, the airport can be reached by taxi or rideshare in roughly 15–25 minutes depending on traffic, with fares commonly in a moderate range; public buses and airport shuttles provide lower-cost options though travel times can be longer. Facilities are usually compact but functional, offering basic dining and shopping; pros include proximity to the city and good domestic connections, while cons can be congestion at peak times and limited premium-lounge choices.

Fly nonstop from Guayaquil to Panama City for the quickest, most convenient way to get between these vibrant cities — less travel time, fewer hassles, and more time to enjoy Panama’s sights. While connecting options can sometimes be cheaper, a direct flight means greater comfort and a simpler schedule, making it ideal for tight itineraries or relaxed travel plans.

Tocumen International Airport (PTY) serves as Panama City’s main international gateway and regional hub, handling most long-haul and connecting flights with carriers such as Copa, American, and LATAM. It’s typically perceived as a mid-to-upper range airport with a wide choice of lounges, shops and transit connections. The airport lies about 24 km (roughly 30–45 minutes by road) from the historic Casco Viejo; taxis, ride-hailing services and airport shuttles are common, with fares that can vary from economical shared shuttles to higher-cost private transfers. Pros: extensive international connections and decent passenger facilities. Cons: can be busy at peak times and ground transfers may be impacted by city traffic.

The minimum one-way ticket price from Guayaquil to Panama City is $149 (April 2026), while the maximum is $646 (March 2026). On average, a ticket costs $317–$803.