There are most likely no direct flights on the Guayaquil — Panama City route
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Guayaquil to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
The minimum one-way ticket price from Guayaquil to Panama City is $171 (January 2027), while the maximum is $183 (March 2027). On average, a ticket costs $177–$183.
A non-stop flight is the most convenient and comfortable way to fly from Guayaquil to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Guayaquil — Panama City route
José Joaquín de Olmedo International Airport (GYE) is Ecuador’s main gateway on the Pacific coast, serving both international flights and a busy mix of domestic services; it typically hosts full-service carriers as well as regional and low-cost operators. Located about 4–6 km northwest of central Guayaquil, the airport can be reached by taxi or rideshare in roughly 15–25 minutes depending on traffic, with fares commonly in a moderate range; public buses and airport shuttles provide lower-cost options though travel times can be longer. Facilities are usually compact but functional, offering basic dining and shopping; pros include proximity to the city and good domestic connections, while cons can be congestion at peak times and limited premium-lounge choices.
Tocumen International Airport (PTY) serves as Panama City’s main international gateway and regional hub, handling most long-haul and connecting flights with carriers such as Copa, American, and LATAM. It’s typically perceived as a mid-to-upper range airport with a wide choice of lounges, shops and transit connections. The airport lies about 24 km (roughly 30–45 minutes by road) from the historic Casco Viejo; taxis, ride-hailing services and airport shuttles are common, with fares that can vary from economical shared shuttles to higher-cost private transfers. Pros: extensive international connections and decent passenger facilities. Cons: can be busy at peak times and ground transfers may be impacted by city traffic.
Guayaquil — Panama City
09/08/2026
Departure
Direct flight
CM313
starting at $346
Guayaquil — Panama City
09/14/2026
Departure
Direct flight
CM214
starting at $678
Guayaquil — Panama City
10/13/2026
Departure
Direct flight
CM214
starting at $271
Guayaquil — Panama City
11/13/2026
Departure
Direct flight
CM313
starting at $270
Guayaquil — Panama City
12/17/2026
Departure
Direct flight
CM272
starting at $209
The route Guayaquil — Panama City is served by several airlines: Copa Airlines, Avianca, and Avianca Ecuador. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $184 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Guayaquil to Panama City according to data for the last 48 hours costs $184
Often the best time to buy tickets from Guayaquil to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Guayaquil to Panama City can be found flying in these months: January, March.
The fastest flights from Guayaquil to Panama City start from 2 hours 16 minutes in the air.
The following airlines operate direct flights on the route Guayaquil — Panama City: Copa Airlines
We couldn't find any special offers for flights from Guayaquil to Panama City
The cheapest one-way flight from Guayaquil to Panama City departs on 11/13/2026, is operated by Avianca and costs $184
The cheapest roundtrip flight from Guayaquil to Panama City departs on 09/12/2026, is operated by Avianca and costs $352
Fastest flight from Guayaquil to Panama City takes 2h 16m
There are direct flights on this route 4 days a week: Mo, Tu, Th, and Fr
The distance between Guayaquil and Panama City is 1244km (771 miles). There are 53 direct flights from Guayaquil to Panama City. Guayaquil and Panama City are in the same time zone. Flights from Guayaquil begin at 4:13 AM. The latest flight from Guayaquil departs at 6:28 PM
