Cheap Flights from Guayaquil to Panama City

Cheapest flights from Guayaquil to Panama City

Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Guayaquil to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.

Cheapest one way flight

$207

Avianca

1 layover

9 hours

01/06/2027

The cheapest one-way flight from Guayaquil to Panama City departs on 01/06/2027, is operated by Avianca and costs $207

Cheapest round trip flight

$399

Avianca

1 layover

1d 4h 20m

11/09/2026

The cheapest roundtrip flight from Guayaquil to Panama City departs on 11/09/2026, is operated by Avianca and costs $399

The fastest flight

2h 12m

Fastest flight from Guayaquil to Panama City takes 2h 12m

Direct flights

Several times a week

There are direct flights on this route 4 days a week: Tu, We, Th, and Fr

Earliest flight

4:13 AM

Latest flight

6:28 PM

Direct flights count

53

Distance

1244km

Timezone difference

0h

The distance between Guayaquil and Panama City is 1244km (771 miles). There are 53 direct flights from Guayaquil to Panama City. Guayaquil and Panama City are in the same time zone. Flights from Guayaquil begin at 4:13 AM. The latest flight from Guayaquil departs at 6:28 PM

Remember that on average the ideal time to book flights is 2 months before departure!

Airfare from Guayaquil to Panama City by month

The minimum one-way ticket price from Guayaquil to Panama City is $201 (November 2026), while the maximum is $313 (September 2027). On average, a ticket costs $257–$313.

November 2026

Lowest price

on average:

$201

September 2027

Highest price

on average:

$313

Avg Price

Airlines operating on route

The route Guayaquil — Panama City is served by several airlines: Copa Airlines, Avianca, and Avianca Ecuador. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $207 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.

Copa Airlines

starting at $209

Avianca

starting at $207

Avianca Ecuador

starting at $216

Non-stop flights from Guayaquil to Panama City

A non-stop flight is the most convenient and comfortable way to fly from Guayaquil to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.

Guayaquil — Panama City

GYE — PTY

11/04/2026

Departure

Direct flight

CM300

starting at $209

Guayaquil — Panama City

GYE — PTY

01/05/2027

Departure

Direct flight

CM300

starting at $220

Guayaquil — Panama City

GYE — PTY

01/07/2027

Departure

Direct flight

CM300

starting at $220

Guayaquil — Panama City

GYE — PTY

10/30/2026

Departure

Direct flight

CM214

starting at $223

Guayaquil — Panama City

GYE — PTY

01/06/2027

Departure

Direct flight

CM377

starting at $216

Schedule of direct flights from Guayaquil to Panama City

There are most likely no direct flights on the Guayaquil — Panama City route

Guayaquil airports overview

Jose Joaquin de Olmedo Airport

•

GYE

Primary international airport serving Guayaquil, Ecuador, handling domestic and international flights; main gateway for travel to the coastal region and Galápagos-bound connections.

•

Panama City airports overview

Marcos A. Gelabert International Airport

•

PAC

34km

Tocumen International Airport

•

PTY

17km

•

Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

What is the cheapest price for flights from Guayaquil to Panama City?

The cheapest flight ticket from Guayaquil to Panama City according to data for the last 48 hours costs $207

When is the best time to buy air tickets on the route Guayaquil — Panama City?

Often the best time to buy tickets from Guayaquil to Panama City is 2 months before departure.

When is the cheapest time of year to fly from Guayaquil to Panama City?

Based on statistics over the past years, the lowest prices for flights from Guayaquil to Panama City can be found flying in these months: November, September.

How long does it take to fly from Guayaquil to Panama City?

The fastest flights from Guayaquil to Panama City start from 2 hours 12 minutes in the air.

Which airline can fly direct from Guayaquil to Panama City?

The following airlines operate direct flights on the route Guayaquil — Panama City: Copa Airlines

Special offers and sales on air tickets from Guayaquil to Panama City

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

We couldn't find any special offers for flights from Guayaquil to Panama City

Alternative routes

Chiclayo ➜ Panama City•Cuenca ➜ Panama City•Esmeraldas ➜ Panama City•Ipiales ➜ Panama City•Loja ➜ Panama City•Manta ➜ Panama City•Piura ➜ Panama City•Pasto ➜ Panama City•Quito ➜ Panama City•Guayaquil ➜ Apartado•Guayaquil ➜ Barranquilla•Guayaquil ➜ Cartago•Guayaquil ➜ Cartagena•Guayaquil ➜ David•Guayaquil ➜ Medellin•Guayaquil ➜ Monteria•Guayaquil ➜ Pereira•Guayaquil ➜ Quibdo

•••••••••••••••••••

Cheapest one way flight

$207

Avianca

1 layover

9 hours

01/06/2027

The cheapest one-way flight from Guayaquil to Panama City departs on 01/06/2027, is operated by Avianca and costs $207

Cheapest round trip flight

$399

Avianca

1 layover

1d 4h 20m

11/09/2026

The cheapest roundtrip flight from Guayaquil to Panama City departs on 11/09/2026, is operated by Avianca and costs $399

The fastest flight