Cheap Flights from Quito to Panama City — $166

Mariscal Sucre International Airport (UIO) is Quito’s primary international gateway, serving a mix of full-service and regional carriers and acting as the country’s main long-haul hub rather than a low-cost base. Located roughly 18–20 km east of the historic center in the Tababela area, travel times to central Quito can vary from about 30–60 minutes depending on traffic and time of day. Ground connections typically include taxis and ride-hailing services (often 25–40 minutes and mid-range fares), airport shuttles and private transfers, while public buses provide a lower-cost but slower option. The airport is modern and convenient for international connections, though road congestion and altitude-related weather can occasionally affect comfort and punctuality.

Tocumen International (PTY) is Panama City’s main international gateway and a regional hub for connecting flights across the Americas; it typically handles major carriers and full-service airlines, with some low-cost options on certain routes. The airport sits about 24 km (roughly 30–40 minutes) east of downtown Panama City by road; options to the city include taxi and ride-hail services (about 25–40 USD typical), airport shuttles and private transfers, plus occasional public buses for a lower-cost alternative. Pros: efficient transfer facilities, multiple lounges and duty-free shopping. Cons: busy peak periods, and fares and transfer times can vary with traffic. For low-cost or domestic travel, smaller regional airfields serve limited routes.

The Quito — Panama City route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $166, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.

Fly direct from Quito to Panama City for the quickest, most convenient way to connect Ecuador’s highland charm with Panama’s vibrant waterfront. While you may occasionally find cheaper connecting options, a nonstop flight saves hours and reduces hassle so you arrive rested and ready to explore. Book now to enjoy the comfort and time-savings of a direct trip between these two dynamic cities.

In different months, ticket prices from Quito to Panama City vary: minimum — $161 (March 2026), maximum — $187 (February 2026). Typically, the flight costs $174–$187.