Starting at $632
Starting at $238
Helping travelers to find the best flight offers
Fly from Quito to Panama City with confidence — we search over 700 airlines, 50+ agencies and 5+ top booking systems to uncover the best prices, schedules and ticket conditions for your trip. Friendly comparisons and real-time options make it easy to pick the flight that fits your budget and timing so you can focus on exploring Panama City.
Fly direct from Quito to Panama City for the quickest, most convenient way to connect Ecuador’s highland charm with Panama’s vibrant waterfront. While you may occasionally find cheaper connecting options, a nonstop flight saves hours and reduces hassle so you arrive rested and ready to explore. Book now to enjoy the comfort and time-savings of a direct trip between these two dynamic cities.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Quito to Panama City:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The Quito — Panama City route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $238, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
Starting at $632
Starting at $238
Quito — Panama City
12/22/2025
Departure
Direct flight
CM153
Starting at $632
Quito — Panama City
02/12/2026
Departure
Direct flight
CM210
Starting at $756
Quito — Panama City
02/16/2026
Departure
Direct flight
CM718
Starting at $712
Quito — Panama City
02/18/2026
Departure
Direct flight
CM153
Starting at $739
Quito — Panama City
07/30/2026
Departure
Direct flight
CM718
Starting at $726
Quito — Panama City
07/31/2026
Departure
Direct flight
CM153
Starting at $726
Quito — Panama City
09/21/2026
Departure
Direct flight
CM153
Starting at $699
Unable to find information about the schedule of direct flights from
Mariscal Sucre International Airport (UIO) is Quito’s primary international gateway, serving a mix of full-service and regional carriers and acting as the country’s main long-haul hub rather than a low-cost base. Located roughly 18–20 km east of the historic center in the Tababela area, travel times to central Quito can vary from about 30–60 minutes depending on traffic and time of day. Ground connections typically include taxis and ride-hailing services (often 25–40 minutes and mid-range fares), airport shuttles and private transfers, while public buses provide a lower-cost but slower option. The airport is modern and convenient for international connections, though road congestion and altitude-related weather can occasionally affect comfort and punctuality.
The cheapest one-way flight from Quito to Panama City departs on 09/21/2026, is operated by Avianca and costs $238
The cheapest roundtrip flight from Quito to Panama City departs on 01/31/2026, is operated by Avianca Ecuador and costs $413
Fastest flight from Quito to Panama City takes 5h 20m
There are no direct flights on this route.
The distance between Quito and Panama City is 1022km (634 miles). There are 39 direct flights from Quito to Panama City. Quito and Panama City are in the same time zone. Flights from Quito begin at 6:00 AM. The latest flight from Quito departs at 3:11 AM
Tocumen International (PTY) is Panama City’s main international gateway and a regional hub for connecting flights across the Americas; it typically handles major carriers and full-service airlines, with some low-cost options on certain routes. The airport sits about 24 km (roughly 30–40 minutes) east of downtown Panama City by road; options to the city include taxi and ride-hail services (about 25–40 USD typical), airport shuttles and private transfers, plus occasional public buses for a lower-cost alternative. Pros: efficient transfer facilities, multiple lounges and duty-free shopping. Cons: busy peak periods, and fares and transfer times can vary with traffic. For low-cost or domestic travel, smaller regional airfields serve limited routes.
We couldn't find any special offers for flights from Quito to Panama City
The cheapest flight ticket from Quito to Panama City according to data for the last 48 hours costs $238
Often the best time to buy tickets from Quito to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Quito to Panama City can be found flying in these months: February, December, July.
The fastest flights from Quito to Panama City start from 5 hours 20 minutes in the air.
The following airlines operate direct flights on the route Quito — Panama City: Copa Airlines
In different months, ticket prices from Quito to Panama City vary: minimum — $253 (February 2026), maximum — $268 (July 2026). Typically, the flight costs $261–$529.