There are most likely no direct flights on the Uyuni — Santa Cruz route
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In different months, ticket prices from Uyuni to Santa Cruz vary: minimum — $157 (September 2026), maximum — $212 (October 2026). Typically, the flight costs $180–$383.
A non-stop flight is the most convenient and comfortable way to fly from Uyuni to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The Uyuni — Santa Cruz route shows a classic seasonal pattern: prices rise, peak, then fall again. Knowing this, you can pick a more affordable time to fly.
Prices rise from September 2026 to October 2026 (+35%), then decline from October 2026 to February 2027 (19%). The cheapest tickets are in September 2026–October 2026 (averaging $184), while the priciest are in October 2026–February 2027 ($191).
For savings, plan your flight for September 2026–October 2026 — you could save up to 4%. Try to avoid October 2026–February 2027 when possible: prices are at their highest then.
Price spread on this route is 12.8%. Costs depend heavily on the season, so flexibility in choosing your departure month is especially valuable here.
There are most likely no direct flights on the Uyuni — Santa Cruz route
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There appear to be no non-stop flights from Uyuni to Santa Cruz at this time.... Well, or something went wrong on our side and we couldn't find anything
starting at $191
You can fly from Uyuni to Santa Cruz with Boliviana de Aviación. It is the only carrier on this route, which makes the choice straightforward. Despite the lack of competition, ticket prices remain affordable: fares start from $191. Our service helps you track price changes, compare by dates, and select the most suitable flight. If you value stability and predictability, flying with Boliviana de Aviación is a convenient solution. We make it easy to find good deals and ensure a comfortable booking process.
The cheapest flight ticket from Uyuni to Santa Cruz according to data for the last 48 hours costs $191
Often the best time to buy tickets from Uyuni to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Uyuni to Santa Cruz can be found flying in these months: September, February, October.
The fastest flights from Uyuni to Santa Cruz start from 4 hours 5 minutes in the air.
The following airlines operate direct flights on the route Uyuni — Santa Cruz:
The cheapest one-way flight from Uyuni to Santa Cruz departs on 05/09/2027, is operated by Boliviana de Aviación and costs $191
There is no information about the cheapest roundtrip flight from Uyuni to Santa Cruz
Fastest flight from Uyuni to Santa Cruz takes 4h 5m
There are no direct flights on this route.
The distance between Uyuni and Santa Cruz is 485km (301 miles). Uyuni and Santa Cruz are in the same time zone
We couldn't find any special offers for flights from Uyuni to Santa Cruz