Cheap Flights from Sao Paulo to Santa Cruz Starting at $154

Sao Paulo is served mainly by two airports with distinct roles. São Paulo–Guarulhos (GRU) is the city’s primary international gateway and a hub for full-service carriers; it typically handles long-haul and regional flights and can be pricier than domestic options. Located about 25–35 km northeast of downtown, travel by airport bus or taxi can take 30–60 minutes depending on traffic, with express bus fares and ride-share/taxi costs varying by provider. Congonhas (CGH) functions as the busy domestic/business airport closer to the city center (around 8–10 km), usually favored by budget and regional carriers for short-haul routes; transfers to central areas are often 15–30 minutes by taxi or metro+bus, generally cheaper but can be crowded at peak times. Pros: GRU offers extensive international connections and more amenities; CGH is convenient for quick city access. Cons: GRU journeys can be longer and affected by traffic; CGH has limited long-haul options and can be noisy and busy.

Fly direct from São Paulo to Santa Cruz for the fastest, most convenient way to reach Bolivia’s vibrant heart—no layovers, less hassle, and more time to enjoy your trip. While connecting flights can sometimes be cheaper, choosing a nonstop gives you added comfort and valuable hours back in your itinerary, perfect for business or leisure travel.

Viru Viru International Airport (VVI) is Santa Cruz’s main international gateway and typically serves as Bolivia’s busiest long-haul and regional hub. Expect a mix of full-service and low-cost carriers operating scheduled flights across South America and to a few international destinations; fares can be competitive compared with smaller domestic-only fields. The airport sits roughly 20–22 km north-west of the city center, with travel options including taxis (30–45 minutes, fares usually moderate), shared shuttles and occasional bus services (longer but cheaper). Pros: more flight choices and basic passenger facilities; cons: the transfer to central Santa Cruz can take time and be affected by traffic.

More than 6 airlines operate flights from Sao Paulo to Santa Cruz, including Gol Transportes Aéreos, Boliviana de Aviación, Avianca, Aerolineas Argentinas, Air Canada, and Azul Brazilian Airlines. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $154, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.