There are most likely no direct flights on the Santiago — Madrid route
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The cost of a one-way flight from Santiago to Madrid ranges from $533 (June 2027) to $630 (September 2026). On average, the ticket price is about $582–$630.
A non-stop flight is the most convenient and comfortable way to fly from Santiago to Madrid, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Santiago — Madrid route
Santiago — Madrid
06/17/2027
Departure
Direct flight
UX120
starting at $533
starting at $533
starting at $630
Flights from Santiago to Madrid are operated by several airlines — Air Europa and JetBlue Airways. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $533, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.
The cheapest flight ticket from Santiago to Madrid according to data for the last 48 hours costs $533
Often the best time to buy tickets from Santiago to Madrid is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Madrid can be found flying in these months: June, September.
The fastest flights from Santiago to Madrid start from 8 hours 15 minutes in the air.
The following airlines operate direct flights on the route Santiago — Madrid: Air Europa
The cheapest one-way flight from Santiago to Madrid departs on 06/17/2027, is operated by Air Europa and costs $533
The cheapest roundtrip flight from Santiago to Madrid departs on 11/26/2026, is operated by Air Europa and costs $838
Fastest flight from Santiago to Madrid takes 8h 15m
There are direct flights on this route 1 day a week: Th
The distance between Santiago and Madrid is 6692km (4149 miles). There are 3 direct flights from Santiago to Madrid. The time difference between Santiago and Madrid is 5h. Flights from Santiago begin at 9:05 PM. The latest flight from Santiago departs at 10:05 PM
We couldn't find any special offers for flights from Santiago to Madrid
