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In different months, ticket prices from Santiago to Santo Domingo vary: minimum — $280 (March 2026), maximum — $295 (February 2026). Typically, the flight costs $286–$577.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Santo Domingo:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Looking for cheap flights from Santiago, Chile to Santo Domingo, Dominican Republic? Look no further! Our air ticket search website offers the best deals for your journey. Santiago, known for its stunning landscapes and vibrant culture, connects you to the lively capital city of Santo Domingo. Immerse yourself in the rich history and beautiful architecture of this Caribbean gem. Discover the enchanting Colonial Zone, indulge in mouthwatering local cuisine, or simply relax on the pristine beaches. With our user-friendly interface, finding the cheapest flights has never been easier. Experience convenience and affordability with our wide selection of flight options. So, wait no more and book your ticket now to embark on an unforgettable adventure from Santiago to Santo Domingo!
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starting at $297
starting at $304
The Santiago — Santo Domingo route is served by multiple airlines, including Sky Airline and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $297, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
The cheapest flight ticket from Santiago to Santo Domingo according to data for the last 48 hours costs $297
Often the best time to buy tickets from Santiago to Santo Domingo is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Santo Domingo can be found flying in these months: March, April, February.
The fastest flights from Santiago to Santo Domingo start from 10 hours 25 minutes in the air.
The following airlines operate direct flights on the route Santiago — Santo Domingo:
Welcome to Santiago, Chile! As you plan your journey, let us guide you through the city's airports to help you find the best departure point for your adventure. Santiago boasts two major airports, each with unique advantages and disadvantages. First, we have Comodoro Arturo Merino Benitez International Airport (SCL), located just 15 kilometers from downtown Santiago. Being the largest airport in Chile, SCL offers excellent connectivity and a wide range of flight options. Airlines like LATAM, Sky Airlines, and JetSMART operate here, ensuring competitive prices and numerous destinations. While the airport's popularity can lead to longer queues during peak hours, its efficient facilities and services make the overall experience smooth. Alternatively, we have Aerodromo de Tobalaba (SCSE), a smaller airport situated only 18 kilometers from downtown Santiago. Although Tobalaba mainly serves general aviation and private flights, it offers a convenient option for travelers seeking a more intimate and time-efficient departure experience. As it caters to smaller aircraft, boarding procedures are faster, saving you valuable time. However, given its smaller scale, there are limited commercial airlines operating from this airport. When considering the airports' accessibility, SCL is well-connected to the city center through various transportation options, including taxis, shuttles, and public buses. Though the journey takes approximately 30 minutes, the convenience justifies the slight cost. On the other hand, Tobalaba benefits from a shorter travel time, with roughly a 20-minute ride to reach the heart of Santiago. In summary, if you prioritize flight options, connectivity, and renowned airlines, Comodoro Arturo Merino Benitez International Airport (SCL) is your go-to choice. However, if time efficiency, comfort, and a smaller departure experience are essential, Aerodromo de Tobalaba (SCSE) may suit your needs better. Whichever airport you choose, our user-friendly air ticket search website will help you find the best deals for your upcoming adventure. Happy travels!
Looking for direct flights from Santiago, Chile to Santo Domingo, Dominican Republic? You're in luck! There are direct flights available on this route, offering you a convenient and time-saving travel option. With no layovers or transfers, you can reach your destination in no time. For those seeking alternative routes, there are a few options available. One common route involves a transfer in Panama City, Panama. Airlines such as Copa Airlines and Avianca offer flights with a stopover in Panama City before heading to Santo Domingo. Another alternative route includes a layover in Miami, Florida, with airlines like American Airlines or Delta Air Lines. While direct flights provide the most efficient travel experience, these alternative routes can still get you to Santo Domingo, albeit with a brief stop along the way. Compare fares and schedules on our air ticket search website to find the best option that suits your preferences and budget. Start planning your trip today!
Santo Domingo, the vibrant capital city of the Dominican Republic, boasts two main airports serving visitors from around the globe. Las Américas International Airport (SDQ) and La Isabela International Airport (JBQ) offer convenient gateways to this tropical paradise. Las Américas International Airport (SDQ), located about 30 minutes from downtown Santo Domingo, welcomes numerous prestigious airlines as their hub, including American Airlines, JetBlue Airways, and Delta Air Lines. With its modern facilities and ample flight options, SDQ ensures a smooth arrival for travelers, ensuring minimal hassle and maximum comfort. On the downside, the distance between SDQ and the city center may require extra travel time and expense. However, local taxis and shuttle services are readily available, making the journey to your destination convenient. La Isabela International Airport (JBQ), situated just 25 minutes from Santo Domingo's city center, offers a more local travel experience. While it might not have as many international flight options as SDQ, it is a popular choice for domestic travelers and regional carriers such as Air Century. JBQ boasts shorter lines and a less crowded atmosphere overall. Travelers should be aware that JBQ mainly handles domestic flights, which may limit the availability of connecting flights. However, for those staying within the Dominican Republic or seeking a more relaxed airport experience, JBQ is a favorable option with its proximity and efficient operations. When choosing between these two airports, consider your travel preferences. SDQ caters to those seeking a wide range of international options, while JBQ provides a local touch and easy access to the city center. Whichever airport you choose, Santo Domingo promises an unforgettable vacation filled with stunning beaches, rich history, and vibrant culture. Book your tickets now and embark on an adventure in this enchanting Caribbean destination!
The cheapest one-way flight from Santiago to Santo Domingo departs on 03/04/2026, is operated by Sky Airline and costs $297
The cheapest roundtrip flight from Santiago to Santo Domingo departs on 03/19/2026, is operated by Avianca and costs $590
Fastest flight from Santiago to Santo Domingo takes 10h 25m
There are no direct flights on this route.
The distance between Santiago and Santo Domingo is 5772km (3579 miles). Santiago and Santo Domingo are in the same time zone
We couldn't find any special offers for flights from Santiago to Santo Domingo