There are most likely no direct flights on the Panama City — Guayaquil route
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A non-stop flight is the most convenient and comfortable way to fly from Panama City to Guayaquil, despite the fact that sometimes flights with transfers can cost significantly less.
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There are most likely no direct flights on the Panama City — Guayaquil route
In different months, ticket prices from Panama City to Guayaquil vary: minimum — $231 (March 2027), maximum — $237 (September 2026). Typically, the flight costs $234–$237.
Panama City — Guayaquil
09/30/2026
Departure
Direct flight
CM213
starting at $314
Panama City — Guayaquil
10/01/2026
Departure
Direct flight
CM213
starting at $245
Panama City — Guayaquil
10/02/2026
Departure
Direct flight
CM273
starting at $244
starting at $244
You can fly from Panama City to Guayaquil with Copa Airlines. It is the only carrier on this route, which makes the choice straightforward. Despite the lack of competition, ticket prices remain affordable: fares start from $244. Our service helps you track price changes, compare by dates, and select the most suitable flight. If you value stability and predictability, flying with Copa Airlines is a convenient solution. We make it easy to find good deals and ensure a comfortable booking process.
The cheapest flight ticket from Panama City to Guayaquil according to data for the last 48 hours costs $244
Often the best time to buy tickets from Panama City to Guayaquil is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Guayaquil can be found flying in these months: March, September.
The fastest flights from Panama City to Guayaquil start from 2 hours 12 minutes in the air.
The following airlines operate direct flights on the route Panama City — Guayaquil: Copa Airlines
The cheapest one-way flight from Panama City to Guayaquil departs on 10/02/2026, is operated by Copa Airlines and costs $244
There is no information about the cheapest roundtrip flight from Panama City to Guayaquil
Fastest flight from Panama City to Guayaquil takes 2h 12m
There are direct flights on this route 3 days a week: We, Th, and Fr
The distance between Panama City and Guayaquil is 1244km (771 miles). There are 51 direct flights from Panama City to Guayaquil. Panama City and Guayaquil are in the same time zone. Flights from Panama City begin at 8:20 AM. The latest flight from Panama City departs at 9:48 PM
We couldn't find any special offers for flights from Panama City to Guayaquil