Cheap Flights from Medellin to Santiago Starting at $257

Helping travelers to find the best flight offers

Cheapest flights from Medellin to Santiago

Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Medellin to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.

Cheapest one way flight

$257

Avianca
Avianca
1 transfer
8h 8m
05/22/2025

The cheapest one-way flight from Medellin to Santiago departs on 05/22/2025, is operated by Avianca and costs $257

Cheapest round trip flight

$301

Jatayu Airlines
Jatayu Airlines
1 transfer
22h 1m
10/13/2025

The cheapest roundtrip flight from Medellin to Santiago departs on 10/13/2025, is operated by Jatayu Airlines and costs $301

The fastest flight

8h 8m

Fastest flight from Medellin to Santiago takes 8h 8m

Direct flights

No direct flights

There are no direct flights on this route.

Distance

4440km

Timezone difference

1h

The distance between Medellin and Santiago is 4440km (2753 miles). The time difference between Medellin and Santiago is 1h .

See also:

Cheap flights to Chile

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Direct flights airfares to Santiago

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Cheapest air tickets to Medellin

Airfare from Medellin to Santiago by month

We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Medellin to Santiago

May 2025
Lowest price
on average:
$257
  • Avg Price

Airlines operating on route

Below you will find a list of airlines operating flights on the Medellin — Santiago route and the starting prices for flights of each specific airline on it.

Avianca
Avianca

Starting at $257

Direct Flights from Medellin to Santiago

A direct flight is the most convenient and comfortable way to fly from Medellin to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.

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There appear to be no direct flights from Medellin to Santiago at this time.... Well, or something went wrong on our side and we couldn't find anything

Schedule of direct flights from Medellin to Santiago

A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Medellin to Santiago:

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Unable to find information about the schedule of direct flights from

Medellin airports overview

MDE
Jose Maria Cordova International Airport
Avianca
Airlines flying to this airport
$257
Starting at
$257
on average

Santiago airports overview

SCL
Arturo Merino Benitez Airport
Avianca
Airlines flying to this airport
$257
Starting at
$257
on average

Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

How much is the cheapest flight ticket from Medellin to Santiago?

The cheapest flight ticket from Medellin to Santiago according to data for the last 48 hours costs $257

When is the best time to buy air tickets on the route Medellin — Santiago?

Often the best time to buy tickets from Medellin to Santiago is 2 months before departure.

When is the cheapest time of year to fly from Medellin to Santiago?

Based on statistics over the past years, the lowest prices for flights from Medellin to Santiago can be found flying in these months: May.

How long does it take to fly from Medellin to Santiago?

The fastest flights from Medellin to Santiago start from 8 hours 8 minutes in the air.

Which airline can fly direct from Medellin to Santiago?

The following airlines operate direct flights on the route Medellin — Santiago:

Special offers and sales on air tickets from Medellin to Santiago

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

Alternative routes

Apartado ➜ Santiago•Armenia ➜ Santiago•Bucaramanga ➜ Santiago•Bogota ➜ Santiago•Cartago ➜ Santiago•Barrancabermeja ➜ Santiago•Ibague ➜ Santiago•Manizales ➜ Santiago•Pereira ➜ Santiago•Quibdo ➜ Santiago•Medellin ➜ San Rafael•Medellin ➜ Concepcion•Medellin ➜ La Rioja•Medellin ➜ Vina del Mar•Medellin ➜ La Serena•Medellin ➜ Mendoza•Medellin ➜ Rio Cuarto•Medellin ➜ Merlo•Medellin ➜ San Juan•Medellin ➜ Temuco