Airlines operating on route
Starting at $223
Starting at $254
Helping travelers to find the best flight offers
Starting at $223
Starting at $254
A direct flight is the most convenient and comfortable way to fly from Medellin to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Medellin to Santiago:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Medellin to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
Below you will find a list of airlines operating flights on the Medellin — Santiago route and the starting prices for flights of each specific airline on it.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Medellin to Santiago
There appear to be no direct flights from Medellin to Santiago at this time.... Well, or something went wrong on our side and we couldn't find anything
The cheapest flight ticket from Medellin to Santiago according to data for the last 48 hours costs $318
Often the best time to buy tickets from Medellin to Santiago is 2 months before departure.
The fastest flights from Medellin to Santiago start from 17 hours 4 minutes in the air.
The following airlines operate direct flights on the route Medellin — Santiago:
Unable to find information about the schedule of direct flights from
We couldn't find any special offers for flights from Medellin to Santiago
The cheapest one-way flight from Medellin to Santiago departs on 07/04/2025, is operated by Copa Airlines and costs $318
The cheapest roundtrip flight from Medellin to Santiago departs on 08/10/2025, is operated by B&H Airlines and costs $387
Fastest flight from Medellin to Santiago takes 17h 4m
There are no direct flights on this route.
The distance between Medellin and Santiago is 4440km (2753 miles). The time difference between Medellin and Santiago is 1h .