starting at $177
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Medellin to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Medellin to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
The only airline operating direct flights from Medellin to Panama City is Copa Airlines. Flights operate every day.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The route Medellin — Panama City is served by a single airline — Copa Airlines. This means that when planning your trip, you won’t need to spend time choosing between dozens of carriers: all flights are operated by one provider, which simplifies the booking process. Despite the limited choice, passengers can still plan ahead, select optimal departure dates, and buy tickets at the lowest price — from $177. Using our service, you can quickly compare available Copa Airlines flights and book a seat in advance at a favorable rate.
starting at $177
Medellin — Panama City
10/21/2026
Departure
Direct flight
CM157
starting at $189
Medellin — Panama City
10/22/2026
Departure
Direct flight
CM757
starting at $189
Medellin — Panama City
10/28/2026
Departure
Direct flight
CM687
starting at $188
Medellin — Panama City
11/17/2026
Departure
Direct flight
CM157
starting at $267
Medellin — Panama City
02/05/2027
Departure
Direct flight
CM209
starting at $197
Medellin — Panama City
02/10/2027
Departure
Direct flight
CM154
starting at $320
Medellin — Panama City
10/29/2026
Departure
Direct flight
CM687
starting at $257
Medellin — Panama City
01/22/2027
Departure
Direct flight
CM151
starting at $254
Medellin — Panama City
11/08/2026
Departure
Direct flight
CM151
starting at $448
Copa Airlines
Every day
starting at $186
All airports
The cheapest one-way flight from Medellin to Panama City departs on 10/29/2026, is operated by Copa Airlines and costs $177
There is no information about the cheapest roundtrip flight from Medellin to Panama City
Fastest flight from Medellin to Panama City takes 1h 29m
There are direct flights on this route 5 days a week: Su, Tu, We, Th, and Fr
The distance between Medellin and Panama City is 531km (329 miles). The average flight duration is 1h 26m. There are 66 direct flights from Medellin to Panama City. Medellin and Panama City are in the same time zone. Flights from Medellin begin at 5:00 AM. The latest flight from Medellin departs at 6:20 PM
Prices on the Medellin — Panama City route are consistently going up. From October 2026 to September 2027, tickets went from $175 to $496 — a 184% increase. This trend is worth considering when planning your trip.
The most significant price increase was from October 2026 to September 2027 — up 184%. The best time to fly is October 2026–November 2026, when the average price is $188. In February 2027–September 2027, tickets cost around $349.
Given the rising prices, it's best not to delay your purchase. Flying in October 2026–November 2026 can save you up to 46% compared to the most expensive months.
Price variation across months on this route is 47.7%. Your choice of departure month significantly affects the total flight cost.
The minimum one-way ticket price from Medellin to Panama City is $175 (October 2026), while the maximum is $496 (September 2027). On average, a ticket costs $254–$404.
The cheapest flight ticket from Medellin to Panama City according to data for the last 48 hours costs $177
Often the best time to buy tickets from Medellin to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Medellin to Panama City can be found flying in these months: October, December, February.
The fastest flights from Medellin to Panama City start from 1 hour 29 minutes in the air.
The following airlines operate direct flights on the route Medellin — Panama City: Copa Airlines
We couldn't find any special offers for flights from Medellin to Panama City