Cheap Flights from Medellin to Panama City Starting at $162
Helping travelers to find the best flight offers
Cheapest flights from Medellin to Panama City
Fly from Medellín to Panama City with ease — our search scans over 700 airlines, 50+ agencies and more than 5 top booking systems to uncover the best prices, schedules and travel conditions for your trip. Compare options in seconds and lock in the ideal connection for business or leisure.
Remember that on average the ideal time to book flights is 2 months before departure!
Fly nonstop from Medellín to Panama City for the quickest, most convenient way to bridge Colombia and Panama—less time in transit and more time exploring. While connecting options can sometimes be cheaper, choosing a direct flight saves hours and reduces hassle for a more comfortable trip, perfect for business or a weekend getaway.
Schedule of direct flights from Medellin to Panama City
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Medellin to Panama City:
Medellin airports overview
Panama City airports overview
Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Medellin to Panama City
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$162
Avianca
1 transfer
4h 15m
11/12/2025
The cheapest one-way flight from Medellin to Panama City departs on 11/12/2025, is operated by Avianca and costs $162
Cheapest round trip flight
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There is no information about the cheapest roundtrip flight from Medellin to Panama City
The fastest flight
3h 58m
Fastest flight from Medellin to Panama City takes 3h 58m
Direct flights
No direct flights
There are no direct flights on this route.
Earliest flight
5:00 AM
Latest flight
6:20 PM
Average flight duration
1h 28m
Direct flights count
72
Distance
531km
Timezone difference
0h
The distance between Medellin and Panama City is 531km (329 miles). The average flight duration is 1h 28m. There are 72 direct flights from Medellin to Panama City. Medellin and Panama City are in the same time zone. Flights from Medellin begin at 5:00 AM. The latest flight from Medellin departs at 6:20 PM
The route Medellin — Panama City is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $162 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
Medellín is served by two main airports with distinct roles. José María Córdova International (MDE) is the primary international gateway, typically handling most long-haul and full-service carriers and often showing higher fares than the city airport; it sits about 35 km east of downtown in Rionegro. Travel to the city center usually takes 40–60 minutes by taxi or shuttle, with fares commonly ranging from modest to mid-level depending on traffic and service; there are also occasional airport buses. Olaya Herrera (EOH) is a smaller domestic and regional airport closer to the city—roughly 5 km from central Medellín—commonly used by budget and regional operators and can be quicker and cheaper for short hops. Ground connections from EOH include taxis and short transfer times of 15–25 minutes; public bus options may be limited. Pros: MDE offers wider international connectivity and more airline choices, while EOH is more convenient for rapid access to central neighborhoods. Cons: MDE’s distance can mean extra transfer time and potential higher costs, and EOH has fewer long-haul options and limited amenities compared with a larger international hub.
Tocumen International (PTY) is Panama City’s main international gateway and regional hub, typically serving full-service carriers and major Latin American and North American airlines alongside some low-cost options. Located about 24 km (roughly 30–40 minutes by car) from central Panama City, it’s commonly reached by taxis, app rides, and occasional airport shuttle buses; expect fares to vary with traffic and service level. For budget travelers, smaller domestic terminals around the city handle regional flights and charter services. Pros: broad international connectivity and modern facilities; cons: peak-hour congestion and a longer transfer into the city compared with inner-city airports. Public bus options are cheaper but slower, while taxis offer faster, more comfortable transfers.
We couldn't find any special offers for flights from Medellin to Panama City
How much is the cheapest flight ticket from Medellin to Panama City?
The cheapest flight ticket from Medellin to Panama City according to data for the last 48 hours costs $162
When is the best time to buy air tickets on the route Medellin — Panama City?
Often the best time to buy tickets from Medellin to Panama City is 2 months before departure.
When is the cheapest time of year to fly from Medellin to Panama City?
Based on statistics over the past years, the lowest prices for flights from Medellin to Panama City can be found flying in these months: November, October.
How long does it take to fly from Medellin to Panama City?
The fastest flights from Medellin to Panama City start from 3 hours 58 minutes in the air.
Which airline can fly direct from Medellin to Panama City?
The following airlines operate direct flights on the route Medellin — Panama City: Copa Airlines
The minimum one-way ticket price from Medellin to Panama City is $182 (November 2025), while the maximum is $190 (October 2025). On average, a ticket costs $186–$190.
