Cheap Flights from Medellin to Panama City — $220

The Medellin — Panama City route is served by a wide range of airlines: 4 in total, including Copa Airlines, Aerorepublica, Avianca, and B&H Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $220. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.

The minimum one-way ticket price from Medellin to Panama City is $228 (May 2026), while the maximum is $240 (June 2026). On average, a ticket costs $233–$471.

Fly from Medellín to Panama City with ease — our search scans over 700 airlines, 50+ agencies and more than 5 top booking systems to uncover the best prices, schedules and travel conditions for your trip. Compare options in seconds and lock in the ideal connection for business or leisure.

Medellín is served by two main airports with distinct roles. José María Córdova International (MDE) is the primary international gateway, typically handling most long-haul and full-service carriers and often showing higher fares than the city airport; it sits about 35 km east of downtown in Rionegro. Travel to the city center usually takes 40–60 minutes by taxi or shuttle, with fares commonly ranging from modest to mid-level depending on traffic and service; there are also occasional airport buses. Olaya Herrera (EOH) is a smaller domestic and regional airport closer to the city—roughly 5 km from central Medellín—commonly used by budget and regional operators and can be quicker and cheaper for short hops. Ground connections from EOH include taxis and short transfer times of 15–25 minutes; public bus options may be limited. Pros: MDE offers wider international connectivity and more airline choices, while EOH is more convenient for rapid access to central neighborhoods. Cons: MDE’s distance can mean extra transfer time and potential higher costs, and EOH has fewer long-haul options and limited amenities compared with a larger international hub.

Fly nonstop from Medellín to Panama City for the quickest, most convenient way to bridge Colombia and Panama—less time in transit and more time exploring. While connecting options can sometimes be cheaper, choosing a direct flight saves hours and reduces hassle for a more comfortable trip, perfect for business or a weekend getaway.

Tocumen International (PTY) is Panama City’s main international gateway and regional hub, typically serving full-service carriers and major Latin American and North American airlines alongside some low-cost options. Located about 24 km (roughly 30–40 minutes by car) from central Panama City, it’s commonly reached by taxis, app rides, and occasional airport shuttle buses; expect fares to vary with traffic and service level. For budget travelers, smaller domestic terminals around the city handle regional flights and charter services. Pros: broad international connectivity and modern facilities; cons: peak-hour congestion and a longer transfer into the city compared with inner-city airports. Public bus options are cheaper but slower, while taxis offer faster, more comfortable transfers.