starting at $211
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Medellin to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Medellin to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
The only airline operating direct flights from Medellin to Panama City is Copa Airlines. Flights operate on Monday, Wednesday, and Thursday.
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The route Medellin — Panama City is served by a single airline — Copa Airlines. This means that when planning your trip, you won’t need to spend time choosing between dozens of carriers: all flights are operated by one provider, which simplifies the booking process. Despite the limited choice, passengers can still plan ahead, select optimal departure dates, and buy tickets at the lowest price — from $211. Using our service, you can quickly compare available Copa Airlines flights and book a seat in advance at a favorable rate.
starting at $211
Medellin — Panama City
09/18/2026
Departure
Direct flight
CM157
starting at $216
Medellin — Panama City
06/23/2026
Departure
Direct flight
CM757
starting at $217
Medellin — Panama City
05/27/2026
Departure
Direct flight
CM757
starting at $217
Medellin — Panama City
07/17/2026
Departure
Direct flight
CM209
starting at $222
Copa Airlines
Mo, We, and Th
starting at $226
Medellín is served by two main airports with distinct roles. José María Córdova International (MDE) is the primary international gateway, typically handling most long-haul and full-service carriers and often showing higher fares than the city airport; it sits about 35 km east of downtown in Rionegro. Travel to the city center usually takes 40–60 minutes by taxi or shuttle, with fares commonly ranging from modest to mid-level depending on traffic and service; there are also occasional airport buses. Olaya Herrera (EOH) is a smaller domestic and regional airport closer to the city—roughly 5 km from central Medellín—commonly used by budget and regional operators and can be quicker and cheaper for short hops. Ground connections from EOH include taxis and short transfer times of 15–25 minutes; public bus options may be limited. Pros: MDE offers wider international connectivity and more airline choices, while EOH is more convenient for rapid access to central neighborhoods. Cons: MDE’s distance can mean extra transfer time and potential higher costs, and EOH has fewer long-haul options and limited amenities compared with a larger international hub.
The cheapest one-way flight from Medellin to Panama City departs on 07/17/2026, is operated by Copa Airlines and costs $211
There is no information about the cheapest roundtrip flight from Medellin to Panama City
Fastest flight from Medellin to Panama City takes 1h 26m
There are direct flights on this route 3 days a week: Tu, We, and Fr
The distance between Medellin and Panama City is 531km (329 miles). The average flight duration is 1h 28m. There are 6 direct flights from Medellin to Panama City. Medellin and Panama City are in the same time zone. Flights from Medellin begin at 5:00 AM. The latest flight from Medellin departs at 6:20 PM
Tocumen International (PTY) is Panama City’s main international gateway and regional hub, typically serving full-service carriers and major Latin American and North American airlines alongside some low-cost options. Located about 24 km (roughly 30–40 minutes by car) from central Panama City, it’s commonly reached by taxis, app rides, and occasional airport shuttle buses; expect fares to vary with traffic and service level. For budget travelers, smaller domestic terminals around the city handle regional flights and charter services. Pros: broad international connectivity and modern facilities; cons: peak-hour congestion and a longer transfer into the city compared with inner-city airports. Public bus options are cheaper but slower, while taxis offer faster, more comfortable transfers.
The cheapest flight ticket from Medellin to Panama City according to data for the last 48 hours costs $211
Often the best time to buy tickets from Medellin to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Medellin to Panama City can be found flying in these months: May, April, July.
The fastest flights from Medellin to Panama City start from 1 hour 26 minutes in the air.
The following airlines operate direct flights on the route Medellin — Panama City: Copa Airlines
The minimum one-way ticket price from Medellin to Panama City is $181 (May 2026), while the maximum is $231 (July 2026). On average, a ticket costs $204–$432.
Tickets from Medellin to Panama City cost roughly the same any month. This is convenient: you can plan your trip based on your schedule rather than prices.
There is a slight difference: it's a bit cheaper in April 2026–May 2026 (averaging $191) and slightly more in May 2026–July 2026 ($206). But overall, the difference is small.
On this route, you don't need to target specific months — prices are stable. The difference between the cheapest and most expensive period is only 7%. Book whenever it's convenient.
Monthly price variation is just 9.9%. Ticket costs on this route are among the most predictable.
We couldn't find any special offers for flights from Medellin to Panama City