When is the cheapest time of year to fly from Sioux Falls to Knoxville?

Based on statistics over the past years, the lowest prices for flights from Sioux Falls to Knoxville can be found flying in these months: .

Cheap Flights from Sioux Falls to Knoxville

Cheapest flights from Sioux Falls to Knoxville

Looking for cheap flights from Sioux Falls to Knoxville? Look no further! Our air ticket search website offers the best deals and discounts on flights between these two cities. With our user-friendly interface, finding the most affordable airfare has never been easier. Plan your trip to Knoxville, the vibrant city in Tennessee, known for its rich history, breathtaking natural beauty, and lively music scene. Whether you're visiting for business or pleasure, our website guarantees the lowest prices on air tickets, so you can save more and explore more. Don't miss out on the opportunity to fly from Sioux Falls to Knoxville without breaking the bank. Start your search now and compare prices from various airlines to find the perfect flight that suits your budget and schedule. Book with us and embark on a memorable journey to Knoxville while saving big.

Cheapest one way flight

$178

American Airlines

1 layover

6h 9m

02/16/2026

The cheapest one-way flight from Sioux Falls to Knoxville departs on 02/16/2026, is operated by American Airlines and costs $178

Cheapest round trip flight

$557

American Airlines

1 layover

13h 31m

03/13/2026

The cheapest roundtrip flight from Sioux Falls to Knoxville departs on 03/13/2026, is operated by American Airlines and costs $557

The fastest flight

6h 9m

Fastest flight from Sioux Falls to Knoxville takes 6h 9m

Direct flights

No direct flights

There are no direct flights on this route.

Distance

1388km

Timezone difference

1h

The distance between Sioux Falls and Knoxville is 1388km (861 miles). The time difference between Sioux Falls and Knoxville is 1h

Remember that on average the ideal time to book flights is 2 months before departure!

Airfare from Sioux Falls to Knoxville by month

We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Sioux Falls to Knoxville

Avg Price

Airlines operating on route

Flights from Sioux Falls to Knoxville are operated by several airlines — American Airlines and Frontier Airlines. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $178, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.

American Airlines

starting at $178

Frontier Airlines

starting at $297

Non-stop flights from Sioux Falls to Knoxville

A non-stop flight is the most convenient and comfortable way to fly from Sioux Falls to Knoxville, despite the fact that sometimes flights with transfers can cost significantly less.

There appear to be no non-stop flights from Sioux Falls to Knoxville at this time.... Well, or something went wrong on our side and we couldn't find anything

Schedule of direct flights from Sioux Falls to Knoxville

A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Sioux Falls to Knoxville:

Unable to find information about the schedule of direct flights from

Sioux Falls airports overview

Sioux Falls Regional Airport (Joe Foss Field)

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FSD

Serving Sioux Falls, South Dakota, the airport offers scheduled domestic flights with major carriers and easy access to downtown, convenient for travel across southeastern South Dakota and nearby Nebraska.

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Knoxville airports overview

McGhee Tyson Airport

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TYS

Serving Knoxville, Tennessee and the Great Smoky Mountains region, provides domestic flights to major U.S. hubs with rental cars, parking, and shuttle connections to downtown and nearby parks.

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Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

What is the cheapest price for flights from Sioux Falls to Knoxville?

The cheapest flight ticket from Sioux Falls to Knoxville according to data for the last 48 hours costs $178

When is the best time to buy air tickets on the route Sioux Falls — Knoxville?

Often the best time to buy tickets from Sioux Falls to Knoxville is 2 months before departure.

How long does it take to fly from Sioux Falls to Knoxville?

The fastest flights from Sioux Falls to Knoxville start from 6 hours 9 minutes in the air.

Which airline can fly direct from Sioux Falls to Knoxville?

The following airlines operate direct flights on the route Sioux Falls — Knoxville:

Special offers and sales on air tickets from Sioux Falls to Knoxville

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

We couldn't find any special offers for flights from Sioux Falls to Knoxville

Alternative routes

Waterloo ➜ Knoxville•Des Moines ➜ Knoxville•Fargo ➜ Knoxville•Lincoln ➜ Knoxville•Minneapolis ➜ Knoxville•Omaha ➜ Knoxville•Rochester ➜ Knoxville•Sioux City ➜ Knoxville•Sioux Falls ➜ Atlanta•Sioux Falls ➜ Asheville•Sioux Falls ➜ Birmingham•Sioux Falls ➜ Nashville•Sioux Falls ➜ Chattanooga•Sioux Falls ➜ Charlotte•Sioux Falls ➜ Charleston•Sioux Falls ➜ Winston-Salem

•••••••••••••••••••

Cheapest one way flight

$178

American Airlines

1 layover

6h 9m

02/16/2026

The cheapest one-way flight from Sioux Falls to Knoxville departs on 02/16/2026, is operated by American Airlines and costs $178

Cheapest round trip flight

$557

American Airlines

1 layover

13h 31m

03/13/2026

The cheapest roundtrip flight from Sioux Falls to Knoxville departs on 03/13/2026, is operated by American Airlines and costs $557

The fastest flight