There are most likely no direct flights on the Santa Cruz — Panama City route
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A non-stop flight is the most convenient and comfortable way to fly from Santa Cruz to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
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There are most likely no direct flights on the Santa Cruz — Panama City route
Santa Cruz — Panama City
11/04/2026
Departure
Direct flight
CM126
starting at $669
Santa Cruz — Panama City
11/03/2026
Departure
Direct flight
CM126
starting at $672
starting at $669
starting at $492
The route Santa Cruz — Panama City is served by several airlines: Copa Airlines and Boliviana de Aviación. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $492 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from Santa Cruz to Panama City according to data for the last 48 hours costs $492
Often the best time to buy tickets from Santa Cruz to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santa Cruz to Panama City can be found flying in these months: November.
The fastest flights from Santa Cruz to Panama City start from 12 hours in the air.
The following airlines operate direct flights on the route Santa Cruz — Panama City: Copa Airlines
The cheapest one-way flight from Santa Cruz to Panama City departs on 11/04/2026, is operated by Boliviana de Aviación and costs $492
There is no information about the cheapest roundtrip flight from Santa Cruz to Panama City
Fastest flight from Santa Cruz to Panama City takes 12 hours
There are direct flights on this route 2 days a week: Tu and We
The distance between Santa Cruz and Panama City is 3480km (2158 miles). There are 14 direct flights from Santa Cruz to Panama City. The time difference between Santa Cruz and Panama City is 1h. Flights from Santa Cruz begin at 11:41 AM. The latest flight from Santa Cruz departs at 1:08 AM
We couldn't find any special offers for flights from Santa Cruz to Panama City