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A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santa Cruz to Panama City:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Unable to find information about the schedule of direct flights from
Santa Cruz — Panama City
01/01/2026
Departure
Direct flight
CM220
starting at $1,014
Santa Cruz — Panama City
01/21/2026
Departure
Direct flight
CM126
starting at $913
Santa Cruz — Panama City
01/22/2026
Departure
Direct flight
CM220
starting at $913
Santa Cruz — Panama City
01/23/2026
Departure
Direct flight
CM126
starting at $913
starting at $913
starting at $357
The route Santa Cruz — Panama City is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $357 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest one-way flight from Santa Cruz to Panama City departs on 01/01/2026, is operated by Avianca and costs $357
The cheapest roundtrip flight from Santa Cruz to Panama City departs on 01/02/2026, is operated by Avianca and costs $685
Fastest flight from Santa Cruz to Panama City takes 11h 20m
There are no direct flights on this route.
The distance between Santa Cruz and Panama City is 3475km (2155 miles). There are 13 direct flights from Santa Cruz to Panama City. The time difference between Santa Cruz and Panama City is 1h. Flights from Santa Cruz begin at 11:40 AM. The latest flight from Santa Cruz departs at 1:15 AM
The cheapest flight ticket from Santa Cruz to Panama City according to data for the last 48 hours costs $357
Often the best time to buy tickets from Santa Cruz to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santa Cruz to Panama City can be found flying in these months: January.
The fastest flights from Santa Cruz to Panama City start from 11 hours 20 minutes in the air.
The following airlines operate direct flights on the route Santa Cruz — Panama City: Copa Airlines
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Santa Cruz to Panama City
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santa Cruz to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
We couldn't find any special offers for flights from Santa Cruz to Panama City
A non-stop flight is the most convenient and comfortable way to fly from Santa Cruz to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.