Helping travelers to find the best flight offers
Find the best deals for flights from San Francisco to Panama City with one simple search — we scan more than 700 airlines, over 50 travel agencies, and 5+ top booking systems to compare prices, schedules, and ticket conditions for you. Whether you prefer nonstop convenience or the cheapest connection, our fast results help you pick the option that fits your budget and travel plans.
Fly nonstop from San Francisco to Panama City for the fastest, most convenient way to reach Panama’s vibrant capital — fewer hassles, no layovers, and more time to enjoy your trip. While connecting flights can sometimes be cheaper, a direct flight saves hours and offers a more comfortable journey, making it worth considering when booking.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from San Francisco to Panama City:
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The cheapest one-way flight from San Francisco to Panama City departs on 12/26/2025, is operated by Frontier Airlines and costs $352
There is no information about the cheapest roundtrip flight from San Francisco to Panama City
Fastest flight from San Francisco to Panama City takes 19h 18m
There are no direct flights on this route.
The distance between San Francisco and Panama City is 5349km (3316 miles). There are 24 direct flights from San Francisco to Panama City. The time difference between San Francisco and Panama City is 3h. Flights from San Francisco begin at 10:55 AM. The latest flight from San Francisco departs at 1:30 AM
The San Francisco — Panama City route is served by a wide range of airlines: 4 in total, including United Airlines, Copa Airlines, Frontier Airlines, and Hawaiian Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $352. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.
Starting at $604
Starting at $964
Starting at $352
Starting at $377
San Francisco — Panama City
12/19/2025
Departure
Direct flight
UA1103
Starting at $831
San Francisco — Panama City
12/26/2025
Departure
Direct flight
CM383
Starting at $1,181
San Francisco — Panama City
12/27/2025
Departure
Direct flight
CM383
Starting at $964
San Francisco — Panama City
12/28/2025
Departure
Direct flight
UA1103
Starting at $672
Unable to find information about the schedule of direct flights from
San Francisco International (SFO) is the region’s primary international hub, serving full-service carriers and many transpacific and transcontinental routes alongside several major US airlines; it can be pricier than nearby secondary airports. Located about 21 km (13 mi) south of downtown San Francisco, SFO is well connected by BART (roughly 30–35 minutes to Market Street, fares around $10–12), airport shuttles and taxis/rideshares (30–45 minutes depending on traffic, fares vary). The airport offers extensive lounges and dining options, making it comfortable for long connections, though security lines and peak-hour congestion can add time. For lower fares, consider nearby Oakland or San Jose alternatives.
Tocumen International Airport (PTY) is Panama City’s main international gateway and a regional connecting hub, especially for long-haul and intercontinental services operated by major carriers and the national airline. It’s located about 24 km (15 miles) east of downtown Panama City, with road transfers typically taking 25–40 minutes by taxi or ride-hail depending on traffic; fares can usually range from moderate to higher compared with local buses. Tocumen offers international lounges, full-service amenities and frequent connections, but can be busy during peak hours and may involve longer walks between gates. For budget-conscious travelers, some low-cost carriers use secondary gates and basic services.
The cheapest flight ticket from San Francisco to Panama City according to data for the last 48 hours costs $352
Often the best time to buy tickets from San Francisco to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from San Francisco to Panama City can be found flying in these months: October, November, December.
The fastest flights from San Francisco to Panama City start from 19 hours 18 minutes in the air.
The following airlines operate direct flights on the route San Francisco — Panama City: United Airlines, Copa Airlines
The minimum one-way ticket price from San Francisco to Panama City is $218 (October 2025), while the maximum is $265 (December 2025). On average, a ticket costs $235–$488.
We couldn't find any special offers for flights from San Francisco to Panama City