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The minimum one-way ticket price from San Francisco to Panama City is $266 (April 2026), while the maximum is $278 (May 2026). On average, a ticket costs $272–$278.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from San Francisco to Panama City:
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Unable to find information about the schedule of direct flights from
San Francisco — Panama City
04/24/2026
Departure
Direct flight
CM383
starting at $965
starting at $965
starting at $264
The route San Francisco — Panama City is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $264 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest flight ticket from San Francisco to Panama City according to data for the last 48 hours costs $264
Often the best time to buy tickets from San Francisco to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from San Francisco to Panama City can be found flying in these months: April, May.
The fastest flights from San Francisco to Panama City start from 15 hours 5 minutes in the air.
The following airlines operate direct flights on the route San Francisco — Panama City: Copa Airlines
The cheapest one-way flight from San Francisco to Panama City departs on 04/25/2026, is operated by Avianca and costs $264
The cheapest roundtrip flight from San Francisco to Panama City departs on 04/14/2026, is operated by Avianca and costs $617
Fastest flight from San Francisco to Panama City takes 15h 5m
There are direct flights on this route 1 day a week: Fr
The distance between San Francisco and Panama City is 5349km (3316 miles). There are 1 direct flight from San Francisco to Panama City. The time difference between San Francisco and Panama City is 3h. Flights from San Francisco begin at 1:35 AM. The latest flight from San Francisco departs at 1:35 AM
San Francisco International (SFO) is the region’s primary international hub, serving full-service carriers and many transpacific and transcontinental routes alongside several major US airlines; it can be pricier than nearby secondary airports. Located about 21 km (13 mi) south of downtown San Francisco, SFO is well connected by BART (roughly 30–35 minutes to Market Street, fares around $10–12), airport shuttles and taxis/rideshares (30–45 minutes depending on traffic, fares vary). The airport offers extensive lounges and dining options, making it comfortable for long connections, though security lines and peak-hour congestion can add time. For lower fares, consider nearby Oakland or San Jose alternatives.
Fly nonstop from San Francisco to Panama City for the fastest, most convenient way to reach Panama’s vibrant capital — fewer hassles, no layovers, and more time to enjoy your trip. While connecting flights can sometimes be cheaper, a direct flight saves hours and offers a more comfortable journey, making it worth considering when booking.
We couldn't find any special offers for flights from San Francisco to Panama City
Tocumen International Airport (PTY) is Panama City’s main international gateway and a regional connecting hub, especially for long-haul and intercontinental services operated by major carriers and the national airline. It’s located about 24 km (15 miles) east of downtown Panama City, with road transfers typically taking 25–40 minutes by taxi or ride-hail depending on traffic; fares can usually range from moderate to higher compared with local buses. Tocumen offers international lounges, full-service amenities and frequent connections, but can be busy during peak hours and may involve longer walks between gates. For budget-conscious travelers, some low-cost carriers use secondary gates and basic services.