Cheap Flights from San Francisco to Panama City Starting at $352
Helping travelers to find the best flight offers
Cheapest flights from San Francisco to Panama City
Find the best deals for flights from San Francisco to Panama City with one simple search — we scan more than 700 airlines, over 50 travel agencies, and 5+ top booking systems to compare prices, schedules, and ticket conditions for you. Whether you prefer nonstop convenience or the cheapest connection, our fast results help you pick the option that fits your budget and travel plans.
Remember that on average the ideal time to book flights is 2 months before departure!
Airfare from San Francisco to Panama City by month
Airlines operating on route
Direct Flights from San Francisco to Panama City
Fly nonstop from San Francisco to Panama City for the fastest, most convenient way to reach Panama’s vibrant capital — fewer hassles, no layovers, and more time to enjoy your trip. While connecting flights can sometimes be cheaper, a direct flight saves hours and offers a more comfortable journey, making it worth considering when booking.
Schedule of direct flights from San Francisco to Panama City
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from San Francisco to Panama City:
San Francisco airports overview
Panama City airports overview
Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from San Francisco to Panama City
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$352
Frontier Airlines
2 transfers
20h 20m
12/26/2025
The cheapest one-way flight from San Francisco to Panama City departs on 12/26/2025, is operated by Frontier Airlines and costs $352
Cheapest round trip flight
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There is no information about the cheapest roundtrip flight from San Francisco to Panama City
The fastest flight
19h 18m
Fastest flight from San Francisco to Panama City takes 19h 18m
Direct flights
No direct flights
There are no direct flights on this route.
Earliest flight
10:55 AM
Latest flight
1:30 AM
Direct flights count
24
Distance
5349km
Timezone difference
3h
The distance between San Francisco and Panama City is 5349km (3316 miles). There are 24 direct flights from San Francisco to Panama City. The time difference between San Francisco and Panama City is 3h. Flights from San Francisco begin at 10:55 AM. The latest flight from San Francisco departs at 1:30 AM
October 2025
Lowest price
on average:
$218
December 2025
Highest price
on average:
$265
Avg Price
The San Francisco — Panama City route is served by a wide range of airlines: 4 in total, including United Airlines, Copa Airlines, Frontier Airlines, and Hawaiian Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $352. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.
San Francisco International (SFO) is the region’s primary international hub, serving full-service carriers and many transpacific and transcontinental routes alongside several major US airlines; it can be pricier than nearby secondary airports. Located about 21 km (13 mi) south of downtown San Francisco, SFO is well connected by BART (roughly 30–35 minutes to Market Street, fares around $10–12), airport shuttles and taxis/rideshares (30–45 minutes depending on traffic, fares vary). The airport offers extensive lounges and dining options, making it comfortable for long connections, though security lines and peak-hour congestion can add time. For lower fares, consider nearby Oakland or San Jose alternatives.
Tocumen International Airport (PTY) is Panama City’s main international gateway and a regional connecting hub, especially for long-haul and intercontinental services operated by major carriers and the national airline. It’s located about 24 km (15 miles) east of downtown Panama City, with road transfers typically taking 25–40 minutes by taxi or ride-hail depending on traffic; fares can usually range from moderate to higher compared with local buses. Tocumen offers international lounges, full-service amenities and frequent connections, but can be busy during peak hours and may involve longer walks between gates. For budget-conscious travelers, some low-cost carriers use secondary gates and basic services.
How much is the cheapest flight ticket from San Francisco to Panama City?
The cheapest flight ticket from San Francisco to Panama City according to data for the last 48 hours costs $352
When is the best time to buy air tickets on the route San Francisco — Panama City?
Often the best time to buy tickets from San Francisco to Panama City is 2 months before departure.
When is the cheapest time of year to fly from San Francisco to Panama City?
Based on statistics over the past years, the lowest prices for flights from San Francisco to Panama City can be found flying in these months: October, November, December.
How long does it take to fly from San Francisco to Panama City?
The fastest flights from San Francisco to Panama City start from 19 hours 18 minutes in the air.
Which airline can fly direct from San Francisco to Panama City?
The following airlines operate direct flights on the route San Francisco — Panama City: United Airlines, Copa Airlines
The minimum one-way ticket price from San Francisco to Panama City is $218 (October 2025), while the maximum is $265 (December 2025). On average, a ticket costs $235–$488.
We couldn't find any special offers for flights from San Francisco to Panama City
