Cheap Flights from Panama City to Medellin Starting at $146
Helping travelers to find the best flight offers
Cheapest flights from Panama City to Medellin
Fly from Panama City to Medellín with confidence — our search checks over 700 airlines, 50+ travel agencies, and more than 5 top booking systems to uncover the best prices, convenient schedules, and flexible conditions. Compare options in seconds and lock in the fare that fits your plans and budget.
Remember that on average the ideal time to book flights is 2 months before departure!
Fly nonstop from Panama City to Medellín for the fastest, most convenient way to reach Colombia’s vibrant City of Eternal Spring—less time in transit means more time exploring. While connecting options can sometimes be cheaper, a direct flight saves you the hassle of layovers and offers a more comfortable, stress-free trip; book now to lock in the best seats and schedules.
Schedule of direct flights from Panama City to Medellin
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Medellin:
Panama City airports overview
Medellin airports overview
Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Panama City to Medellin
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$146
Avianca
1 transfer
4 hours
10/28/2025
The cheapest one-way flight from Panama City to Medellin departs on 10/28/2025, is operated by Avianca and costs $146
Cheapest round trip flight
$300
Avianca
1 transfer
8h 5m
01/31/2026
The cheapest roundtrip flight from Panama City to Medellin departs on 01/31/2026, is operated by Avianca and costs $300
The fastest flight
1h 25m
Fastest flight from Panama City to Medellin takes 1h 25m
Direct flights
Once a week
There are direct flights on this route 1 day a week: Tu
Earliest flight
6:53 AM
Latest flight
9:29 PM
Average flight duration
1h 10m
Direct flights count
81
Distance
531km
Timezone difference
0h
The distance between Panama City and Medellin is 531km (329 miles). The average flight duration is 1h 10m. There are 81 direct flights from Panama City to Medellin. Panama City and Medellin are in the same time zone. Flights from Panama City begin at 6:53 AM. The latest flight from Panama City departs at 9:29 PM
November 2025
Lowest price
on average:
$164
October 2025
Highest price
on average:
$173
Avg Price
The Panama City — Medellin route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $146, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
Unable to find information about the schedule of direct flights from
Tocumen International Airport (PTY) serves Panama City as the country’s primary international hub, handling most long-haul and regional flights and acting as a common connecting point in Central America. It’s typically used by full-service carriers and major regional airlines, while some low-cost carriers operate select routes. Tocumen sits about 24–28 km (roughly 30–45 minutes) from the historic Casco Viejo and downtown, with taxis, app rides and airport shuttles available; fares can range widely depending on service and traffic. Pros: modern terminal, many onward connections and decent passenger facilities. Cons: can be busy during peak times and transit times to the city vary with rush-hour congestion.
Medellín is served by two main airports with distinct roles. José María Córdova International (MDE) in Rionegro is the primary international gateway and a regional hub for full-service carriers, while Olaya Herrera (EOH) close to downtown typically handles domestic and regional flights, often favored by budget and regional operators. MDE sits roughly 35–40 km (about 45–60 minutes by road) from the city center; common transfers include taxis, private shuttles and intercity buses with fares usually higher than city transit. EOH is much closer—around 5–10 minutes or 3–5 km—reachable by taxi or bus at low cost. MDE can be more comfortable for long-haul connections and offers more amenities, but the longer transfer can add time and cost; EOH is convenient for quick domestic hops though facilities may be more basic.
We couldn't find any special offers for flights from Panama City to Medellin
How much is the cheapest flight ticket from Panama City to Medellin?
The cheapest flight ticket from Panama City to Medellin according to data for the last 48 hours costs $146
When is the best time to buy air tickets on the route Panama City — Medellin?
Often the best time to buy tickets from Panama City to Medellin is 2 months before departure.
When is the cheapest time of year to fly from Panama City to Medellin?
Based on statistics over the past years, the lowest prices for flights from Panama City to Medellin can be found flying in these months: November, October.
How long does it take to fly from Panama City to Medellin?
The fastest flights from Panama City to Medellin start from 1 hour 25 minutes in the air.
Which airline can fly direct from Panama City to Medellin?
The following airlines operate direct flights on the route Panama City — Medellin: Copa Airlines
In different months, ticket prices from Panama City to Medellin vary: minimum — $164 (November 2025), maximum — $173 (October 2025). Typically, the flight costs $169–$173.
