Cheap Flights from Panama City to Medellin — $148

Tocumen International Airport (PTY) serves Panama City as the country’s primary international hub, handling most long-haul and regional flights and acting as a common connecting point in Central America. It’s typically used by full-service carriers and major regional airlines, while some low-cost carriers operate select routes. Tocumen sits about 24–28 km (roughly 30–45 minutes) from the historic Casco Viejo and downtown, with taxis, app rides and airport shuttles available; fares can range widely depending on service and traffic. Pros: modern terminal, many onward connections and decent passenger facilities. Cons: can be busy during peak times and transit times to the city vary with rush-hour congestion.

Fly nonstop from Panama City to Medellín for the fastest, most convenient way to reach Colombia’s vibrant City of Eternal Spring—less time in transit means more time exploring. While connecting options can sometimes be cheaper, a direct flight saves you the hassle of layovers and offers a more comfortable, stress-free trip; book now to lock in the best seats and schedules.

Medellín is served by two main airports with distinct roles. José María Córdova International (MDE) in Rionegro is the primary international gateway and a regional hub for full-service carriers, while Olaya Herrera (EOH) close to downtown typically handles domestic and regional flights, often favored by budget and regional operators. MDE sits roughly 35–40 km (about 45–60 minutes by road) from the city center; common transfers include taxis, private shuttles and intercity buses with fares usually higher than city transit. EOH is much closer—around 5–10 minutes or 3–5 km—reachable by taxi or bus at low cost. MDE can be more comfortable for long-haul connections and offers more amenities, but the longer transfer can add time and cost; EOH is convenient for quick domestic hops though facilities may be more basic.

We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Panama City to Medellin

The Panama City — Medellin route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $148, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.