There are most likely no direct flights on the Panama City — Medellin route
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Panama City to Medellin. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
In different months, ticket prices from Panama City to Medellin vary: minimum — $150 (November 2026), maximum — $161 (October 2026). Typically, the flight costs $156–$161.
A non-stop flight is the most convenient and comfortable way to fly from Panama City to Medellin, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Panama City — Medellin route
All airports
Panama City — Medellin
11/24/2026
Departure
Direct flight
CM654
starting at $157
Panama City — Medellin
11/14/2026
Departure
Direct flight
CM397
starting at $157
Panama City — Medellin
01/09/2027
Departure
Direct flight
CM654
starting at $168
Panama City — Medellin
11/28/2026
Departure
Direct flight
CM764
starting at $196
Panama City — Medellin
11/25/2026
Departure
Direct flight
CM150
starting at $198
Panama City — Medellin
10/25/2026
Departure
Direct flight
CM397
starting at $227
Panama City — Medellin
11/27/2026
Departure
Direct flight
CM208
starting at $242
Panama City — Medellin
10/25/2026
Departure
Direct flight
CM155
starting at $245
Panama City — Medellin
10/24/2026
Departure
Direct flight
CM163
starting at $255
Panama City — Medellin
10/31/2026
Departure
Direct flight
CM150
starting at $383
starting at $157
starting at $191
The Panama City — Medellin route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $157, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
The cheapest flight ticket from Panama City to Medellin according to data for the last 48 hours costs $157
Often the best time to buy tickets from Panama City to Medellin is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Medellin can be found flying in these months: November, October.
The fastest flights from Panama City to Medellin start from 1 hour 18 minutes in the air.
The following airlines operate direct flights on the route Panama City — Medellin: Copa Airlines
The cheapest one-way flight from Panama City to Medellin departs on 11/24/2026, is operated by Copa Airlines and costs $157
There is no information about the cheapest roundtrip flight from Panama City to Medellin
Fastest flight from Panama City to Medellin takes 1h 18m
There are direct flights on this route 5 days a week: Su, Tu, We, Fr, and Sa
The distance between Panama City and Medellin is 531km (329 miles). There are 62 direct flights from Panama City to Medellin. Panama City and Medellin are in the same time zone. Flights from Panama City begin at 6:49 AM. The latest flight from Panama City departs at 9:24 PM
We couldn't find any special offers for flights from Panama City to Medellin
