Cheap Flights from Lisbon to Santiago — $453

Lisbon Humberto Delgado Airport (LIS) is Portugal’s main international gateway and typically functions as a full-service hub with a mix of legacy carriers and low-cost airlines. Located about 7 km northeast of the city centre, it can be reached in roughly 20–30 minutes by metro (around €1.50–€2.00), 20–40 minutes by taxi or ride-share (fares varying by time and traffic), and 25–45 minutes by airport shuttle or bus. The airport usually offers a broad choice of connections across Europe, Africa and the Americas, with generally mid-range fares compared with other Western European capitals. Pros: frequent transit links and extensive services; cons: can be busy during peak hours and traffic may affect road travel times.

Fly direct from Lisbon to Santiago for the fastest, most convenient way to cross the Atlantic and start exploring Chile without long layovers. While connecting itineraries can sometimes be cheaper, a non‑stop flight saves hours and offers a more comfortable, hassle‑free journey—perfect for maximizing your time in Santiago.

The Lisbon — Santiago route is served by a wide range of airlines: 4 in total, including LATAM Chile, Air Europa, Transavia, and Royal Air Maroc. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $453. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.

The minimum one-way ticket price from Lisbon to Santiago is $453 (April 2026), while the maximum is $740 (December 2026). On average, a ticket costs $598–$1,341.

Comodoro Arturo Merino Benítez (SCL) is Santiago’s main international gateway and typically functions as Chile’s busiest hub, serving full-service carriers like LATAM alongside a growing number of low-cost and regional airlines. Located about 15–20 km northwest of downtown, it’s usually reachable in 20–40 minutes by taxi or ride-hail (fares commonly varying with traffic), or by airport bus and shuttle services that can take 30–50 minutes at lower cost. Transfers to intercity buses and car rental desks are convenient for onward travel. Pros: comprehensive services, frequent international connections and modern terminals; cons: can be busy at peak times and delays to the city may occur with congestion.