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A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Guayaquil:
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Answers to questions about the route that travelers are most interested in.
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Unable to find information about the schedule of direct flights from
Looking for cheap flights from Santiago, Chile to Guayaquil, Ecuador? Look no further! Our air ticket search website offers a wide range of affordable options for your travel needs. With our user-friendly interface, finding the best deals has never been easier. Fly from Santiago, Chile to Guayaquil, Ecuador and explore the vibrant cultural scene, picturesque landscapes, and delicious cuisine that this South American destination has to offer. Whether you're traveling for business or pleasure, our website ensures that you can save both time and money on your flight bookings. Book your flight today and embark on an unforgettable journey from Santiago, Chile to Guayaquil, Ecuador. Don't wait - start planning your adventure now with our affordable flight options!
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Santiago to Guayaquil
Santiago — Guayaquil
01/21/2026
Departure
Direct flight
LA1446
starting at $447
Santiago — Guayaquil
01/22/2026
Departure
Direct flight
XL1446
starting at $527
Santiago — Guayaquil
01/23/2026
Departure
Direct flight
LA1446
starting at $279
Santiago — Guayaquil
01/30/2026
Departure
Direct flight
LA1446
starting at $489
Santiago — Guayaquil
02/06/2026
Departure
Direct flight
LA1446
starting at $558
Santiago — Guayaquil
03/04/2026
Departure
Direct flight
LA1446
starting at $331
starting at $248
starting at $527
starting at $209
starting at $231
The Santiago — Guayaquil route is served by a wide range of airlines: 4 in total, including LATAM Chile, LATAM Ecuador, Avianca, and Copa Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $209. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.
The cheapest flight ticket from Santiago to Guayaquil according to data for the last 48 hours costs $209
Often the best time to buy tickets from Santiago to Guayaquil is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Guayaquil can be found flying in these months: January.
The fastest flights from Santiago to Guayaquil start from 9 hours 50 minutes in the air.
The following airlines operate direct flights on the route Santiago — Guayaquil: LATAM Chile, LATAM Ecuador
The cheapest one-way flight from Santiago to Guayaquil departs on 03/04/2026, is operated by Avianca and costs $209
There is no information about the cheapest roundtrip flight from Santiago to Guayaquil
Fastest flight from Santiago to Guayaquil takes 9h 50m
There are direct flights on this route 3 days a week: We, Th, and Fr
The distance between Santiago and Guayaquil is 3610km (2238 miles). There are 8 direct flights from Santiago to Guayaquil. The time difference between Santiago and Guayaquil is 1h. Flights from Santiago begin at 12:45 AM. The latest flight from Santiago departs at 12:45 AM
A non-stop flight is the most convenient and comfortable way to fly from Santiago to Guayaquil, despite the fact that sometimes flights with transfers can cost significantly less.
We couldn't find any special offers for flights from Santiago to Guayaquil
