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Fly from Panama City to Santiago with confidence — our search scans over 700 airlines, 50+ agencies and 5+ top booking systems to uncover the best prices, schedules and travel conditions for your trip. Compare options in seconds and book the flight that fits your budget and timing with ease.
Fly nonstop from Panama City to Santiago for the fastest, most convenient way to get between these two vibrant cities — less hassle, no layovers, and more time to enjoy your trip. While connecting options can sometimes be cheaper, a direct flight saves hours and offers a more comfortable, stress-free journey worth considering when planning your travel.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Santiago:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Panama City to Santiago
Arturo Merino Benítez International Airport (SCL) is Santiago’s main international gateway and typically serves as Chile’s primary long‑haul and regional hub, handling legacy carriers and many full‑service international airlines alongside low‑cost operators. Located about 15 km northwest of downtown Santiago, travel times to the city center are commonly 20–40 minutes by taxi or ride‑share (fares usually in a mid‑range band) and 30–45 minutes by the express bus or planned rail links; routes and times can vary with traffic. Pros: convenient for most international connections and well equipped with lounges and services. Cons: peak‑hour congestion and occasional longer transfer times for budget passengers using distant terminal areas.
Unable to find information about the schedule of direct flights from
The cheapest one-way flight from Panama City to Santiago departs on 12/28/2025, is operated by Avianca and costs $298
There is no information about the cheapest roundtrip flight from Panama City to Santiago
Fastest flight from Panama City to Santiago takes 10h 25m
There are no direct flights on this route.
The distance between Panama City and Santiago is 4810km (2982 miles). There are 41 direct flights from Panama City to Santiago. The time difference between Panama City and Santiago is 1h. Flights from Panama City begin at 11:48 AM. The latest flight from Panama City departs at 9:28 PM
Tocumen International Airport (PTY) is Panama City’s primary international gateway and the region’s major connecting hub, handling most long-haul and regional flights and serving flag carrier Copa Airlines alongside international carriers. It’s located about 24 km (roughly 30–45 minutes by car depending on traffic) from downtown Panama City; taxis and ride-hailing services are common, with fares typically in the moderate range, while the Metro Line 2 extension and airport shuttle options can be cheaper but may take longer. The airport usually offers a wide choice of lounges and shops, making connections comfortable, though busy peak periods can mean longer security and immigration waits. Albrook “Marcos A. Gelabert” International Airport (PAC) functions as a smaller, more domestic-focused alternative close to the city center, commonly serving budget carriers and regional flights. Situated right next to the Albrook district, it is typically only 5–10 minutes by car or a short Metro ride from central neighborhoods, with low to moderate taxi fares and good access to local buses. The airport can be more convenient for short-haul travel due to its proximity and simpler layout, but it offers fewer international connections and amenities than Tocumen, which may be a trade-off for budget-conscious or time-sensitive travelers.
Panama City — Santiago
12/28/2025
Departure
Direct flight
CM395
starting at $1,089
Panama City — Santiago
03/07/2026
Departure
Direct flight
CM497
starting at $1,183
starting at $1,089
starting at $298
The Panama City — Santiago route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $298, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
The cheapest flight ticket from Panama City to Santiago according to data for the last 48 hours costs $298
Often the best time to buy tickets from Panama City to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Santiago can be found flying in these months: December.
The fastest flights from Panama City to Santiago start from 10 hours 25 minutes in the air.
The following airlines operate direct flights on the route Panama City — Santiago: Copa Airlines