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A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Medellin to Santa Cruz:
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Answers to questions about the route that travelers are most interested in.
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Unable to find information about the schedule of direct flights from
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Medellin to Santa Cruz. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
There appear to be no non-stop flights from Medellin to Santa Cruz at this time.... Well, or something went wrong on our side and we couldn't find anything
starting at $270
You can fly from Medellin to Santa Cruz with Avianca. It is the only carrier on this route, which makes the choice straightforward. Despite the lack of competition, ticket prices remain affordable: fares start from $270. Our service helps you track price changes, compare by dates, and select the most suitable flight. If you value stability and predictability, flying with Avianca is a convenient solution. We make it easy to find good deals and ensure a comfortable booking process.
The cheapest one-way flight from Medellin to Santa Cruz departs on 04/14/2026, is operated by Avianca and costs $270
There is no information about the cheapest roundtrip flight from Medellin to Santa Cruz
Fastest flight from Medellin to Santa Cruz takes 7h 20m
There are no direct flights on this route.
The distance between Medellin and Santa Cruz is 2997km (1858 miles). The time difference between Medellin and Santa Cruz is 1h
A non-stop flight is the most convenient and comfortable way to fly from Medellin to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
The cheapest flight ticket from Medellin to Santa Cruz according to data for the last 48 hours costs $270
Often the best time to buy tickets from Medellin to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Medellin to Santa Cruz can be found flying in these months: April.
The fastest flights from Medellin to Santa Cruz start from 7 hours 20 minutes in the air.
The following airlines operate direct flights on the route Medellin — Santa Cruz:
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Medellin to Santa Cruz
We couldn't find any special offers for flights from Medellin to Santa Cruz