There are most likely no direct flights on the Cuzco — Santa Cruz route
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A non-stop flight is the most convenient and comfortable way to fly from Cuzco to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Cuzco — Santa Cruz route
There appear to be no non-stop flights from Cuzco to Santa Cruz at this time.... Well, or something went wrong on our side and we couldn't find anything
starting at $279
On the Cuzco — Santa Cruz route, flights are operated only by Sky Airline. This simplifies the choice for passengers, as all tickets come from a single trusted carrier. Our service lets you instantly check fares for upcoming dates and find the most advantageous option. The minimum ticket price starts at $279, making this trip affordable for a wide range of travelers. To save even more, we recommend booking early and keeping an eye on promotions — Sky Airline regularly offers special deals.
The cheapest one-way flight from Cuzco to Santa Cruz departs on 11/06/2026, is operated by Sky Airline and costs $279
There is no information about the cheapest roundtrip flight from Cuzco to Santa Cruz
Fastest flight from Cuzco to Santa Cruz takes 1d 6h 20m
There are no direct flights on this route.
The distance between Cuzco and Santa Cruz is 1053km (653 miles). The time difference between Cuzco and Santa Cruz is 1h
The cheapest flight ticket from Cuzco to Santa Cruz according to data for the last 48 hours costs $279
Often the best time to buy tickets from Cuzco to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Cuzco to Santa Cruz can be found flying in these months: August, February.
The fastest flights from Cuzco to Santa Cruz start from 6 hours 20 minutes in the air.
The following airlines operate direct flights on the route Cuzco — Santa Cruz:
The cost of a one-way flight from Cuzco to Santa Cruz ranges from $248 (August 2026) to $271 (February 2027). On average, the ticket price is about $259–$271.
We couldn't find any special offers for flights from Cuzco to Santa Cruz